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In this experiment we tested the effects of some vegetable extracts (biopreparations) of Polygonum aviculare L.(knotgrass) and Polygonum bistorta L.(meadow bistort), from the Polygonaceae family, on some vital organs, in experimental rats. The duration of experiment was of 10 days, when we have daily gavaged a group of femal Wistar rats, with 1 ml vegetable extract of Polygonum aviculare, prepared from plant's aerial part and the other group also received 1 ml vegetable extract of Polygonum bistorta, from the caudices of the plant. After 10 days rats were sacrificed and blood samples were taken for determination of serum transaminases activity (GPT and GOT). Also, were removed samples of brain - hipotalamus, adrenal glands, liver, kidney and thin gut (duodenum). From adrenals was determined the cholesterol content. At the analyzed organs level was made the histology with help of hematoxylin - eosine staining emphasizing the neuro - endocrine - pituitary - adrenal axis reaction. The metabolic organs as the liver, kidney and duodenum were also investigated through the determination of some enzymes activity such are: lactate dehidrogenase, succinat-dehidrogenase, Mg-dependent adenosine triphosphatase, cytochromoxidase. The obtained results were grouped analyzed, after methodologies. Thus, on the biochemical plans, the GPT level doesn't have a significantly modification, but diminishes the GOT level into treated groups. The cholesterol content in adrenals doesn't modify. As concern the histologic structure of analized organs we point out, in forerank, at the pituitary level, an easier stimulation of neuro-endocrine secretion at the neuron level and on the axonal route, but without any pathologically signification. In the remainder, the structure of the analyzed organs there is any pathological modifications in adrenals, liver, kidney and duodenum. As concern analyzed histochemical and histoenzymological activity it doesn't modify in vegetable extracts treated groups compared with control group, with a little exception, namely, in the treated groups at the duodenum level the ATP-ase activity is easier increased compared with the control group. In conclusion, the administration of Polygonum aviculare and Polygonum bistorta extracts don't produces any pathological effects at the neuro-endocrine axis level and in the metabolic studied organs. There are no differences between the action of those two vgetable extracts obtained from different species, at least in our experimental conditions. [ABSTRACT FROM AUTHOR]