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Introduction. Bacterial meningitis is caused by a variety of germs, of which Gram positive bacteria (Streptococcus pneumonie, Streptococcus agalactie, Stafilococcus aureus, Lysteria monocitogenes) caused severe forms of the diseases with neurological complications, recurrent diseases and death. Pneumococcal meningitis can affect all age groups, especially, young children, elderly and immunocompromised persons. The incidence in worldwide is about 47%, only in USA 13-17%. Cranial trauma and otolaryngologic diseases are associated with recurrent meningitis. Objective. To analyzed the incidence of pneumococcal meningitis, especially recurrent, risk factors and their evolution under treatment. Matherial and method. Retrospectiv study on 324 patients diagnosed with pneumococcal meningitis in Clinical Hospital of Infectious Diseases Constanta in the last five years. Results. From 220 patients with different bacterial etiology, 66 patients (30%) have pneumococcal meningitis and 8 patients recurrent meningitis. The risk factors were cranial trauma (4 cases), chronic otitis (2 cases), chronic otomastoiditis (1 case) and chronic maxillary sinusitis (1 case). Two patients died and one patient complicated with hearing loss. Conclusions. Despite the therapeutic and diagnostic progress, pneumococcal meningitis remained severe diseases, with high risk of neurological sequels and fatality. We notice a low sensibility of Streptococcus pneumonie in recurrent meningitis. [ABSTRACT FROM AUTHOR]

Objective. Highlighting seborrheic dermatitis prevalence in HIV patients and evaluating clinico-therapeutical correlations. Material and methods. Between 1.10.2011 - 31.12.2014 we performed a prospective study on a group of 121 HIV-positive patients hospitalized in the HIV Adults Department in the Infectious Diseases Hospital, Constanta, to determine the prevalence, clinical particularities and treatment response of seborrheic dermatitis in HIV + patients. Results. Seborrheic dermatitis has been reported in 33.05% of patients, predominantly male (M:F = 9:1), with peak incidence in the 20-30 age group. Lesions prevalence according to the site of seborrheic dermatitis was: face (15%), scalp (22.5%), face and scalp (45%), chest (12.5%). In terms of clinical severity, 27.5% patients had mild seborrheic dermatitis, while 62.5% had moderate seborrheic dermatitis, and 10% were diagnosed with the severe form. Therapeutic response was evaluated at day 7, 14 and after 8 weeks, assessing the decrease/disappearance of erythema and flaking, and pruritus improvement/remission. After 8 weeks of treatment, complete remission was reported in 70% patients. However, HIV+ patients with seborrheic dermatitis had between 2-5 episodes per year, relapses being reported at 4 to 12 weeks after discontinuation of treatment, mean 7 weeks. Conclusions. The present study indicates a moderate prevalence of seborrheic dermatitis in hospitalized HIV+ patients. Although clinical manifestations do not differ from those of seborrheic dermatitis in seronegative patients, the clinical course of disease reveals the extensive character of seborrheic dermatitis in HIV+ patients with more severe lesions, refractory to treatment, and frequent recurrences, even in patients receiving prolonged treatment. [ABSTRACT FROM AUTHOR]

Objectives. To describe particular aspects of dermatoses in HIV-positive patients and assess clinical and therapeutical correlations. Material and methods. A systematic review was performed of the medical literature, totaling 49 works, to evaluate information on the following dermatological diseases: syphilis malignant, pruritic papular eruption of HIV, molluscum contagiosum, infection due to varicella-zoster virus or human papilloma virus, cutaneous histoplasmosis, Kaposi's sarcoma, non-melanoma skin carcinomas, skin and soft tissue infections, HIV associated pruritus, HIV immune reconstruction syndrome (IRIS) associated dermatoses, vitiligo, lupus erythematosus, and Norwegian scabies. Results. Dermatological conditions are among the first clinical manifestations of AIDS, the number of patients with dermatitis being inversely proportional to the CD4 + count and proportionate to the stage of disease. Mucocutaneous manifestations associated with HIV-1 infection are classified into primary and secondary, but their pathogenesis is not completely elucidated, and secondary complications are associated with a lower HIV prevalence since HAART has become available. Conclusions. The majority of dermatological diseases in HIV positive patients have a clinically more severe course, with a prolonged evolution, are more resistant to treatment, tend to recur more frequently and may exacerbate during the first months of initiating HAART, due to immune reconstruction inflammatory syndrome. [ABSTRACT FROM AUTHOR]