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Infantile hemangioma (IH) is the most common vascular tumour of infancy and childhood. His are benign tumours that appears usually days or weeks after birth, but some of them show precursor lesions such as anemic, reddish-blue or blue maculae, telangiectasias and port-wine stain lesions. Bacille Calmette Guerin (BCG) is the current vaccine for tuberculosis. It was first used in 1921. There were described different cutaneous reactions or complications at the injection site or at distance. We describe a case of IH arising at the site of BCG vaccination in an infant, situation which has not been reported in the literature [ABSTRACT FROM AUTHOR]

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Introducere. Nevul Spitz este o leziune melanocitară benignă, cel mai frecvent întâlnită la copil şi adultul tânăr, la nivelul capului şi extremităţilor, cu o evoluţie rapidă de ordinul lunilor, ce îngrijorează familia şi medicul. Scop. Evidenţierea dificultăţilor de diagnosticare clinică, dermoscopică şi histopatologică într-o leziune ce poate simula melanomul. Material şi metodă. Prezentăm două cazuri de nev Spitz apărute la vârsta de 10 şi respectiv 16 ani, o leziune hiperpigmentată, neagră şi o alta nepigmentată, roză, trimise în consult cu suspiciunea de malignitate. Ambele leziuni au fost evaluate dermoscopic şi histopatologic. Rezultate. Diagnosticul final a fost de nev Spitz clasic pentru leziunea nepigmentată şi de nev Spitz atipic (tumoră spitzoidă cu potenţial malign incert) pentru leziunea pigmentată. Concluzii. Diagnosticarea nevului Spitz continuă să fie o provocare clinică, dermoscopică şi, nu în ultimul rând, histopatologică, iar excizia chirurgicală este recomandată în majoritatea cazurilor. [ABSTRACT FROM AUTHOR]

Immunofluorescence is an useful tool for diagnosing and monitoring disease remission in pemphigus group of disorders. We demonstrated the presence of characteristic immune deposits by performing direct immunofluorescence both on skin fragments and anagen hair follicles in pemphigus vulgaris patients. Using the hair follicles as an alternate substrate for direct immunofluorescence has the potential of substituting skin or mucosal fragments taken by biopsies but a larger number of cases is needed in order to validate the method. [ABSTRACT FROM AUTHOR]