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99 results on '"17-Hydroxycorticosteroids metabolism"'

1. [Effect of milk proteins and their enzymatic hydrolyzates on non-specific resistance of some systems to food allergens].

Author

Malikova NA, Krzhechkovskaia VV, Samenkova NF, Sazhinov GIu, and Marokko IN

Subjects
17-Hydroxycorticosteroids metabolism, Animals, Chymotrypsin metabolism, Cytochrome P-450 Enzyme System metabolism, Guinea Pigs, Male, Protein Hydrolysates metabolism, Trypsin metabolism, Gastric Mucosa metabolism, Intestine, Small metabolism, Liver metabolism, Milk Hypersensitivity immunology, Milk Hypersensitivity metabolism, Milk Proteins pharmacology
Abstract

Noninbred male guinea-pigs (b. mass 250-300 g) were kept for 35 days on diets in which 50% of standard proteins were replaced for cow milk protein (CMP) 20/80 and its enzymatic hydrolyzate (EH) 20/80 obtained by ultrafiltration. CMP 20/80 and EH 20/80 have been examined for the effect on proteolytic activity of gastric mucosa, small intestinal activity of trypsin and chymotrypsin, hepatic cytochrome P-450 and metabolism of excreted 17-OCS. The animals given EH 20/80 exhibited enhanced total proteolytic activity of trypsin and chymotrypsin, higher total levels of cytochromes P-450 and P-450B in the liver, increased urine excretion of 17-OCS, reduced amount of polar forms in all the glucocorticoid fractions. Potential mechanisms securing the action of enzymatic hydrolyzates on the systems responsible for nonspecific resistance to food allergens are suggested for discussion.

Published
1993

2. [The effect of cow's milk and its hydrolysates on the metabolism of 17-hydroxycorticosteroids and the functional state of the gastrointestinal tract in guinea pigs].

Author

Malikova NA, Marokko IN, Samenkova NF, Gmoshinskiĭ IV, and Mazo VK

Subjects
Animals, Digestive System drug effects, Digestive System metabolism, Guinea Pigs, Male, 17-Hydroxycorticosteroids metabolism, Digestive System Physiological Phenomena, Milk Proteins pharmacology, Protein Hydrolysates pharmacology
Abstract

Two groups of noninbred male guinea pigs (initial bw 250-300 g) received test rations in which 50% of standard ration protein were substituted for milk protein (P 20/80) and its enzymatic hydrolysate (H 20/80). The influence of P 20/80 and H 20/80 on some parameters of the gastro-intestinal tract (GIT) barrier function and 17-OCS metabolism was studied. The action of H 20/80 as compared to P 20/80 was expressed in the intensified excretion of free fraction of 17-OCS and glucuronides. The content of hydroxylated glucocorticoids increased in both fractions. At the same time elevated total proteolytic activity in the gastric mucosa and a tendency to decreased GIT permeability for chicken ovalbumin macromolecules were observed in animals that received H 20/80. It has been suggested that enzymatic hydrolysates of food proteins influence endocrine regulation of metabolic processes.

Published
1991

4. [Non-alternative elements in the pathogenesis of peptic ulcer and their modulation with sodium nucleinate].

Author

Perederiĭ VG and Zemskov AM

Subjects
17-Hydroxycorticosteroids metabolism, Adult, Cyclic AMP deficiency, Duodenal Ulcer drug therapy, Humans, Lymphopenia complications, Middle Aged, RNA metabolism, Stomach Ulcer drug therapy, T-Lymphocytes immunology, Anti-Ulcer Agents therapeutic use, Duodenal Ulcer etiology, Nucleic Acids therapeutic use, Stomach Ulcer etiology
Published
1983

5. [Functional state of the adrenal cortex in patients with Parkinsonism before and after surgical treatment].

Author

Lapshin ND, Chaban AS, and Pogorzhel'skiĭ VS

Subjects
17-Hydroxycorticosteroids metabolism, 17-Ketosteroids urine, Adrenocorticotropic Hormone, Adult, Female, Humans, Male, Middle Aged, Parkinson Disease physiopathology, Potassium metabolism, Sodium metabolism, Adrenal Cortex physiopathology, Adrenal Glands physiopathology, Parkinson Disease surgery, Thalamic Nuclei surgery
Abstract

The results of biochemical examinations of the hormonal function of the adrenal cortex in 22 patients with Parkinson's disease are presented as seen prior and following stereotaxic operations on the ventro-lateral nucleus of the thalamus. It was found that parkinsonics have a decreased androgenic, glucocorticoid and mineralocorticoid function of the adrenal cortex. Long history and growing severity of the disease manifest themselves in a distinct inhibition of the adrenal cortex function. The importance of the changes in the functional state of the hypothalamo-hypophyseal system in the revealed disorders in the hormonal activity is emphasized. Along with a beneficial clinical effect surgery brings about an improvement of the functional state of the adrenal cortex.

Published
1977

8. [Obesity and the functions of beta-cells of the insular apparatus of the pancreas].

Author

Genes CG

Subjects
17-Hydroxycorticosteroids metabolism, 17-Ketosteroids metabolism, Adipose Tissue metabolism, Adipose Tissue pathology, Adrenal Glands metabolism, Animals, Antigens, Blood Glucose analysis, Cell Count, Fatty Acids, Nonesterified blood, Fatty Acids, Nonesterified metabolism, Female, Glucose metabolism, Growth Hormone metabolism, Humans, Insulin blood, Insulin metabolism, Insulin Resistance, Insulin Secretion, Liver metabolism, Male, Mice, Obesity blood, Obesity pathology, Proinsulin blood, Rats, Sex Factors, Hyperinsulinism complications, Islets of Langerhans metabolism, Obesity etiology
Published
1974

9. [Insulin receptors of adipose tissue cells in increased levels of anti-insulin hormones].

Author

Bezdrobnyĭ IuV, Efimov AS, Evdokimova NIu, Komissarenko IV, and Demchenko NP

Subjects
17-Hydroxycorticosteroids metabolism, Adipose Tissue ultrastructure, Adult, Aged, Catecholamines metabolism, Cell Membrane metabolism, Diabetes Mellitus etiology, Female, Growth Hormone metabolism, Humans, Male, Middle Aged, Adipose Tissue metabolism, Insulin metabolism, Insulin Antagonists metabolism, Receptor, Insulin metabolism
Published
1984

14. [Correlation between immunological reactivity and the fat-carbohydrate metabolism. Influence of phenformin].

Author

Dil'man VM, Nemirovskiĭ VS, Ostroumova MN, L'vovich EG, and Blagosklonnaia IaV

Subjects
17-Hydroxycorticosteroids metabolism, 17-Ketosteroids metabolism, Adult, Age Factors, Aged, Cholesterol metabolism, Dexamethasone pharmacology, Female, Glucose metabolism, Humans, Hydrocortisone metabolism, Immunity, Cellular drug effects, Lipoproteins, LDL metabolism, Lymphocyte Activation, Male, Middle Aged, Triglycerides metabolism, Carbohydrate Metabolism, Immunity drug effects, Lipid Metabolism, Phenformin pharmacology
Abstract

Based on the conceptions of the relationship between energy and adaptation-immunological systems a number of hormone-metabolic indices were compared with immune reactivity as evidenced by skin tests and rosette-formation reaction. It is shown that lowering of immunological indices in oncological patients is associated with a decreased sensitivity of dexametasone suppression of cortisol, an increased concentration of 11-oxycorticosteroids in blood, a higher level of triglycerides, cholestrol, beta-lipoproteins and less glucose tolerance. The use of phenformin during 3 months in patients with atherosclerosis resulted in a considerable increase of the index of phytohemagglutinin stimulated blasttransformation of lymphocytes and rosette-formation reaction. This effect was associated with normalization of lipid metabolism indices.

Published
1976

15. [Neuro-humoral mechanisms of development of Itsenko-Cushing disease (review of the literature)].

Author

Soskin LS and Usol'tsev AN

Subjects
17-Hydroxycorticosteroids metabolism, Adrenal Cortex metabolism, Adrenal Cortex Hormones metabolism, Adrenocortical Hyperfunction complications, Adrenocortical Hyperfunction etiology, Adrenocorticotropic Hormone metabolism, Animals, Circadian Rhythm, Corticosterone metabolism, Corticotropin-Releasing Hormone metabolism, Cushing Syndrome metabolism, Humans, Hypothalamus metabolism, Male, Pituitary Gland, Anterior metabolism, Rats, Cushing Syndrome etiology
Published
1976

17. [Effect of a permanent magnetic field on the endocrine system].

Author

Zagorskaia EA

Subjects
17-Hydroxycorticosteroids metabolism, Adrenal Cortex physiology, Animals, Estrus, Female, Guinea Pigs, Humans, Male, Mice, Pituitary-Adrenal System physiology, Pregnancy, Rats, Sympathetic Nervous System physiology, Testis physiology, Endocrine Glands physiology, Magnetics
Abstract

The review of the reported data indicates that endocrine glands react to the constant magnetic field (CMF). The paper presents information about the phasic pattern of hypophyseal-adrenal reaction and CMF effects on the sympathoadrenal system and thyroid. The review refers to many publications demonstrating high sensitivity to testes of the CMF. The paper discusses potential therapeutic applications of the CMF with emphasis on the fact that most morphological data available need biochemical support.

Published
1981

19. [Status of the pituitary-adrenal cortex system in primary hypothyroidism].

Author

Rom-Bugoslavskaia ES, Sakhatov BIa, and Zaĭtseva LI

Subjects
17-Hydroxycorticosteroids metabolism, Adrenocorticotropic Hormone metabolism, Circadian Rhythm, Humans, Hydrocortisone metabolism, Thyrotropin metabolism, Adrenal Cortex metabolism, Hypothyroidism physiopathology, Pituitary Gland, Anterior metabolism
Published
1989

20. [Role of corticosteroids in the regulation of protein metabolism in physical exertion].

Author

Viru AA

Subjects
17-Hydroxycorticosteroids metabolism, 17-Ketosteroids metabolism, Adaptation, Physiological, Alanine Transaminase blood, Alanine Transaminase metabolism, Amino Acids metabolism, Animals, Corticosterone blood, Energy Metabolism, Hydrocortisone metabolism, Liver enzymology, Rats, Glucocorticoids physiology, Muscle Proteins metabolism, Muscles metabolism, Physical Exertion
Published
1977

21. [Excretion of estrogens by the salivary and stomach glands].

Author

Popov IuD and Novikova MN

Subjects
17-Hydroxycorticosteroids urine, 17-Ketosteroids urine, Adult, Age Factors, Female, Gastric Juice analysis, Humans, Kidney metabolism, Male, Middle Aged, Saliva analysis, Sex Factors, 17-Hydroxycorticosteroids metabolism, 17-Ketosteroids metabolism, Gastric Mucosa metabolism, Salivary Glands metabolism
Published
1974

22. [Characteristics of various adaptive reactions in patients with endometriosis].

Author

Suprun LIa

Subjects
11-Hydroxycorticosteroids blood, 17-Hydroxycorticosteroids metabolism, Adaptation, Physiological, Adrenocorticotropic Hormone blood, Adult, Catecholamines metabolism, Female, Humans, Middle Aged, Endometriosis physiopathology, Ovarian Neoplasms physiopathology, Pituitary-Adrenal System physiopathology, Uterine Neoplasms physiopathology
Published
1982

25. [Electrolyte metabolism and the condition of glucocorticoid and mineralocorticoid functions of the adrenal cortex in different forms of Itsenko-Cushing's syndrome].

Author

Vasiukova EA, Granovskaia AM, Kasatkin IuN, Ryzhikov VD, and Avramenko MM

Subjects
17-Hydroxycorticosteroids metabolism, Adolescent, Adrenal Cortex metabolism, Adult, Cortisone metabolism, Cushing Syndrome physiopathology, Female, Humans, Male, Middle Aged, Adrenal Cortex physiopathology, Adrenal Glands physiopathology, Aldosterone metabolism, Cushing Syndrome metabolism, Glucocorticoids metabolism, Potassium metabolism, Sodium metabolism
Published
1975

26. [Effect of infecundin on glucocorticoid function of the adrenal cortex in patients with dyshormonal hyperplasia of the endometrium].

Author

Rotkina IE

Subjects
17-Hydroxycorticosteroids blood, 17-Hydroxycorticosteroids urine, Adolescent, Adult, Drug Combinations, Endometrial Hyperplasia drug therapy, Endometrial Hyperplasia metabolism, Female, Humans, Mestranol pharmacology, Middle Aged, Norethynodrel pharmacology, Precancerous Conditions metabolism, 17-Hydroxycorticosteroids metabolism, Adrenal Glands drug effects, Endometrial Hyperplasia physiopathology, Mestranol therapeutic use, Norethynodrel therapeutic use, Precancerous Conditions drug therapy
Published
1974

27. [Etiopathogenesis and treatment of trophic ulcers in venous pathology of the lower extremities].

Author

Les'ko VA

Subjects
17-Hydroxycorticosteroids metabolism, Adrenal Cortex metabolism, Adrenal Cortex physiopathology, Adult, Aged, Cortisone therapeutic use, Enzymes blood, Female, Follow-Up Studies, Glucocorticoids blood, Humans, Lipoproteins blood, Magnesium blood, Male, Middle Aged, Phosphorus blood, Procaine therapeutic use, Leg blood supply, Leg Ulcer blood, Leg Ulcer drug therapy, Leg Ulcer enzymology, Leg Ulcer etiology, Leg Ulcer physiopathology, Leg Ulcer therapy, Venous Insufficiency complications
Published
1974

31. [Mechanism of corticosteroid metabolism in contact allergic dermatitis].

Author

Bagratuni BE and Kogan VIu

Subjects
Animals, Brain metabolism, Dermatitis, Contact etiology, Guinea Pigs, Liver metabolism, Male, Molybdenum adverse effects, Myocardium metabolism, 11-Hydroxycorticosteroids metabolism, 17-Hydroxycorticosteroids metabolism, Dermatitis, Contact metabolism
Published
1989

32. [Effect of the solvents used for steroid crystallization on the process of the 21-acetate hydroxylation of Reichstein's S substance by a culture of the fungus, Tieghemella orchidis].

Author

Iusim RS, Mart'ianova VN, Tropina VI, Demchenko BI, and Shemeriankin BV

Subjects
Acetates, Crystallization, Culture Media, Hydrocortisone analogs & derivatives, Hydrocortisone biosynthesis, Hydroxylation, Microchemistry methods, 17-Hydroxycorticosteroids metabolism, Fungi metabolism, Pregnenediones metabolism, Solvents pharmacology
Published
1974

34. [Effect of ethyl ether of p-chlorphenoxyisobutyric acid on the glucocorticoid function of the adrenal cortex of guinea pigs].

Author

Laskavaia AI, Simon IB, Fisun SD, and Sharkevich IN

Subjects
17-Hydroxycorticosteroids antagonists & inhibitors, Adrenal Cortex drug effects, Adrenocortical Hyperfunction drug therapy, Adrenocorticotropic Hormone pharmacology, Animals, Clofibrate therapeutic use, Drug Evaluation, Guinea Pigs, In Vitro Techniques, 17-Hydroxycorticosteroids metabolism, Adrenal Cortex metabolism, Adrenal Glands metabolism, Clofibrate pharmacology
Abstract

In administration to quinea pigs of ethyl-p-chlorophenoxyisobutyrate daily in a dose of 0.2 g/kg per os for 15-26 days decreased the 17-OHCS concentration in the peripheral blood plasma. A fall of the urinary excretion of individual 17-OHCS occurred chiefly at the expense of free unchanged cortisol, tetrahydrocortisol and tetrahydro-11-desoxycortisol. The zona fasciculate displays the abundance of the sudanophilic material. A test with ACTH demonstrated that the present functional reserves of the adrenal cortex failed to change under the effect of the preparation. The content of NEFA decreased in the blood serum; as to cholesterol level - it reamined unchanged. Possible mechanisms of the action of the preparation and prospects of its use for the treatment of hypercorticism are discussed.

Published
1976

35. [Effect of discontinuous heat exposure on the functional state of the adrenal cortex].

Author

Afanas'ev BG, Vol'fson TI, and Getsoĭ ZV

Subjects
17-Hydroxycorticosteroids metabolism, 17-Ketosteroids metabolism, Adaptation, Physiological, Adrenal Cortex metabolism, Adult, Atmosphere Exposure Chambers, Humans, Male, Potassium metabolism, Sodium metabolism, Temperature, Time Factors, Adrenal Cortex physiology, Adrenal Glands physiology, Hot Temperature adverse effects
Published
1977

37. [Comparative characteristics of certain indicators of metabolism in infectious-allergic and atopical forms of bronchial asthma in children].

Author

Balabolkin II, Iurkov IuA, and Gerasimova IuV

Subjects
17-Hydroxycorticosteroids metabolism, Adenosine Diphosphate metabolism, Adenosine Monophosphate metabolism, Adenosine Triphosphate metabolism, Child, Child, Preschool, Glycosaminoglycans metabolism, Histidine metabolism, Humans, Purines metabolism, Pyrimidinones metabolism, Tryptamines metabolism, Asthma metabolism
Published
1974

38. [Insulin resistance and anti-insulin hormones].

Author

Efimov AS, Bezverkhaia TP, Shevchenko ZhB, and Petakh NN

Subjects
Adolescent, Adult, Aged, Child, Diabetes Mellitus drug therapy, Female, Humans, Insulin therapeutic use, Male, Middle Aged, 17-Hydroxycorticosteroids metabolism, Catecholamines metabolism, Growth Hormone metabolism, Hydrocortisone metabolism, Insulin Antagonists, Insulin Resistance, Thyroid Hormones metabolism
Published
1976

39. [Steroid hormone level in patients with Itsenko-Cushing disease].

Author

Bezverkhaia TP, Komissarenko IV, Verkhogliadova LM, Erofeeva EN, and Savitskaia VV

Subjects
17-Hydroxycorticosteroids metabolism, Adolescent, Adult, Circadian Rhythm, Corticosterone metabolism, Cortisone blood, Estrogens metabolism, Female, Humans, Hydrocortisone metabolism, Male, Middle Aged, Pregnanediol urine, Progesterone blood, Testosterone metabolism, Cushing Syndrome metabolism, Glucocorticoids metabolism, Gonadal Steroid Hormones metabolism
Abstract

A study was made of the content of cortisol, corticosterone, 11-deoxycortisol, estradiol, testosterone and progesterone in the blood plasma using radioimmunoassay and of the content of these hormones or their main metabolites in the daily urine using physicochemical methods in 77 patients with an active stage of the Icenko-Cushing disease. An acute increase in cortisol secretion, a noticeable rise of progesterone secretion, and significant deviations in testosterone production having opposite nature in men and women were established: in men androgen content in the body was lowered, in women raised. The adrenals were shown to be the main site of testosterone and progesterone secretion in female patients. One-type disorders of the rhythm of secretion of hormones determined during one day (disappearance or reduction of daily variations) were revealed.

Published
1985

41. [Enzymatic breakdown of steroids during 11 alpha- and 11 beta-hydroxylation of the 21-acetate of Reichstein's "substance S" by Tieghemella orchidis (fam. Mucoraceae)].

Author

Mogil'nitskiĭ GM, Andreev LV, and Koshcheenko KA

Subjects
Hydroxylation, 17-Hydroxycorticosteroids metabolism, Cortodoxone metabolism, Fungi metabolism, Mucorales metabolism
Abstract

By-products of the transformation were studied, which were formed in the process of 11alpha and 11beta-hydroxylation of 21-acetate of the Reichstein substance "S" by the culture of Tieghemella orchidis. The following steroid derivatives, known before, were isolated: epihydrocortisone, 6beta-hydroxy derivative of the Reichstein substance "S", hydrocortisone, cortisone. The following steroid derivatives were isolated from the initial chloroform extract of the fermentation medium, and identified: prednisolone, androstendione, testololactone, and 1,2-dehydro derivatives of the Reichstein substance S" and its 21-acetate. The quantitative ratio between the products of transformation depended on the conditions of growth and transformation. These compounds seem to be intermediate metabolites in the course of the steroid destruction via the pathway common for fungi and involving the destruction of D ring of the steroid molecule.

Published
1975

43. [Hypothalamo-hypophyseal-adrenal system function in rheumatoid arthritis].

Author

Khetagurova ZV

Subjects
17-Hydroxycorticosteroids metabolism, Adolescent, Adrenocorticotropic Hormone blood, Adult, Aged, Female, Free Radicals, Humans, Hydrocortisone blood, Male, Middle Aged, Pregnanediol blood, Arthritis, Rheumatoid physiopathology, Hypothalamo-Hypophyseal System physiopathology, Pituitary-Adrenal System physiopathology
Published
1982

46. [Effect of large doses of reserpine on the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing's disease].

Author

Marova EI, Butrova SA, and Kolesnikova GS

Subjects
17-Hydroxycorticosteroids metabolism, Adrenocorticotropic Hormone blood, Adult, Clinical Trials as Topic, Cortodoxone blood, Dose-Response Relationship, Drug, Drug Evaluation, Female, Humans, Hydrocortisone blood, Male, Metyrapone, Time Factors, Cushing Syndrome drug therapy, Hypothalamo-Hypophyseal System drug effects, Pituitary-Adrenal System drug effects, Reserpine administration & dosage
Abstract

The results of study of the hypothalamo-hypophysio-adrenal system in patients with Itsenko-Cushing's disease under the influence of high reserpine doses are presented. An increase of plasma ACTH and cortizol level and disturbance of the 24-hour rhythm of their secretion was noted in the patients. High reserpine doses led to the fall of ACTH and cortizol secretion, without any normalization of their secretion rhythm in the course of 24 hours. A test with metopyron carried out before and after the reserpine prescription pointed to the increase of the ACTH reserve under the influence of high reserpine doses.

Published
1978

48. [The functional state of the adrenal cortex in aging].

Author

Svechnikova NV and Bekker VI

Subjects
17-Ketosteroids blood, 17-Ketosteroids urine, Adolescent, Adrenocorticotropic Hormone pharmacology, Adult, Aged, Androsterone metabolism, Chromatography, Eosinophils, Female, Humans, Male, Middle Aged, Sex Factors, 17-Hydroxycorticosteroids metabolism, 17-Ketosteroids metabolism, Adrenal Glands physiology, Aging
Published
1970

50. [The state of various factors of humoral regulation in patients with rhinosinusopathy].

Author

Filatov VF

Subjects
Adult, Female, Humans, Male, Middle Aged, Nasal Polyps complications, Nose Neoplasms complications, Rhinitis complications, Sinusitis complications, 17-Hydroxycorticosteroids metabolism, Catecholamines metabolism, Nasal Polyps metabolism, Nose Neoplasms metabolism, Rhinitis metabolism, Sinusitis metabolism
Published
1971

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