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Perinatal and infant mortality in the Arkhangelsk Region tends to decline. At the same time, the structure of perinatal mortality shows a significant increase in the proportion of congenital defects, among which multiple forms constitute a major portion. The most common causes of infant death are acute respiratory infections, congenital malformations, and sudden infant death syndrome.

Gastroschisis is considered by the authors to be an embryopathy. The main principles of management of newborns with gastroschisis are: warming of the newborn, rehydration, measures against pseudoobstruction of the intestine. An effective method which could be recommended for all kinds of operations for defects of the anterior abdominal wall is a "manual enlargement of the abdominal cavity" during operation.

The authors analyze clinical material and autopsy findings of fetuses and children dying at the age from 0 to 15 years during the last 15 years. For etiological evaluation of developmental congenital malformations the authors analyzed anamnesis, genealogy, dermatoglyphics, table materials, biochemical examination, karyotyping. The most frequent organs involved were the central nervous system, cardiovascular system, gastrointestinal tract and to a lesser degree--the genitourinary, osseous and respiratory systems. Congenital developmental malformations were registered in 10.2% of cases: in the prenatal period from 13.1 to 16.2% at different age. Among the children who died with developmental congenital malformations most were in the first year of their life.