5 results on '"Alexandrov, V. A."'
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2. Improving the Hydraulic Drive of the Undercarriage of a Combine Harvester
- Author
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Morozova, A. A. and Alexandrov, V. A.
- Subjects
ГИДРОНАСОС ,HYDRAULIC SYSTEM ,ECONOMIC EFFICIENCY ,IMPROVEMENT ,ГИДРОСИСТЕМА ,UNDERCARRIAGE OF A COMBINE HARVESTER ,PRESSURE ,ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ ,HYDRAULIC MOTOR ,HYDRAULIC PUMP ,СОВЕРШЕНСТВОВАНИЕ ,ХОДОВАЯ ЧАСТЬ ЗЕРНОУБОРОЧНОГО КОМБАЙНА ,ГИДРОМОТОР ,ОБЪЕМНЫЙ ГИДРОПРИВОД ,ДАВЛЕНИЕ ,VOLUMETRIC HYDRAULIC DRIVE - Abstract
Анализ конструкций современных отечественных и зарубежных сельскохозяйственных машин показал, что одной из наиболее ответственных систем, влияющих на надежность техники, является объемный гидропривод. Примером такого гидропривода является гидростатическая трансмиссия, состоящая из сложных дорогостоящих аксиально-поршневых агрегатов. По данным научно-технической литературы доля объемных гидроприводов в трансмиссиях современной технике для АПК не менее 35 %, а на отказы гидропривода в доремонтный период эксплуатации приходится до 20 % от общего числа отказов машин [ 1, 3]. Analysis of the designs of modern domestic and foreign agricultural machines has shown that one of the most important systems that affect the reliability of equipment is a volumetric hydraulic drive. An example of such a hydraulic drive is a hydrostatic transmission consisting of complex, expensive axial-piston units. According to scientific and technical literature, the share of volume hydraulic drives in transmissions of modern equipment for agriculture is not less than 35 %, and hydraulic drive failures in the pre-repair period of operation account for up to 20 % of the total number of machine failures [ 1, 3]. At the present stage of development of agricultural machinery, agricultural machinery is faced with the task of developing and producing machines that allow maximum saving of raw materials, fuel and energy resources at the stages of production, processing and use of agricultural products. In the conditions of modern production, productivity, efficiency and reliability of agricultural machinery increases, their mass per unit of power decreases, and the accuracy of manufacturing products increases.
- Published
- 2020
3. [Relationship between benign prostatic hyperplasia and prostate cancer: new opportunities for prostate cancer chemoprevention].
- Author
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Bespalov VG, Kuzhanov AA, Vasilieva IN, Semenov AL, and Alexandrov VA
- Subjects
- Humans, Male, Risk Factors, Antineoplastic Agents therapeutic use, Prostatic Hyperplasia metabolism, Prostatic Hyperplasia pathology, Prostatic Hyperplasia prevention & control, Prostatic Neoplasms metabolism, Prostatic Neoplasms pathology, Prostatic Neoplasms prevention & control
- Abstract
In a review article the relationship between benign prostatic hyperplasia (BPH) and prostate cancer (PC) has been conducted. Epidemiological data on increasing the risk of PC in patients with BPH are presented. There are discussed common for BPH and PC constitutional, food, and life style etiologic factors and also common for the both diseases pathogenetic factors such as androgens, inflammation, metabolic syndrome. Pharmaceutical drugs and natural agents that have unidirectional therapeutic and preventive effect on BPH and PC are presented. Results of experimental studies of the authors to prove the link between BPH and PC are presented. It is concluded that BPH is a risk factor for PC and, ideally, drugs for the treatment of BPH should have a chemo preventive effect on PC.
- Published
- 2016
4. [Therapeutic activity of gemcitabine in intracranial tumors].
- Author
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Stukov AN, Filatova LV, Latipova DKh, Bespalov VG, Belyaeva OA, Kireeva GS, Vasilieva IN, Alexandrov VA, Maidin MA, Semenov AL, Vershinina SF, Markochev AB, Abduloeva NKh, Chubenko VA, and Semiglazova TY
- Subjects
- Animals, Antimetabolites, Antineoplastic administration & dosage, Brain Neoplasms etiology, Carmustine administration & dosage, Cisplatin administration & dosage, Cyclophosphamide administration & dosage, Deoxycytidine administration & dosage, Deoxycytidine pharmacology, Injections, Intraperitoneal, Male, Mice, Neoplasm Transplantation, Gemcitabine, Antimetabolites, Antineoplastic pharmacology, Antineoplastic Combined Chemotherapy Protocols pharmacology, Blood-Brain Barrier drug effects, Blood-Brain Barrier metabolism, Brain Neoplasms drug therapy, Carcinoma, Ehrlich Tumor drug therapy, Deoxycytidine analogs & derivatives
- Abstract
Gemcitabine is known to exert a therapeutic effect on brain tumors despite the limited permeability of the blood-brain barrier (BBB). In our experimental research single intraperitoneal (i.p.) injection of gemcitabine 25 mg/kg provided increase in median survival of mice with intracranially transplanted Ehrlich carcinoma by 41-89% (p < 0.001). In this experimental model i.p. administration of gemcitabine (permeability of the BBB of less than 10%), carmustine (good permeability of the BBB), cyclophosphamide (poor permeability of the BBB) and cisplatin (doesn't penetrate through the BBB) increased median survival of mice by 88% (p < 0.001), 59% (p = 0.001), 35% (p = 0.005) and 18% (p = 0.302) respectively. Considering strong correlation between antitumor activity of the drugs (carmustine, cyclophosphamide and cisplatin) and their permeability of the BBB, efficacy of gemcitabine in intracranial tumors could be due to its wide range of therapeutic doses.
- Published
- 2015
5. [Intraperitoneal chemotherapy--a method of improving treatment effectiveness in ovarian cancer].
- Author
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Bespalov VG, Vyshinskaya EA, Vasilieva IN, Maidin MA, Semenov AL, Stukov AN, Kireeva GS, Belyaeva OA, Kopteva OS, Krasilnikova LA, Alexandrov VA, and Belyaev AM
- Subjects
- Animals, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Cisplatin administration & dosage, Cyclophosphamide administration & dosage, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Female, Infusions, Intravenous, Maximum Tolerated Dose, Melphalan administration & dosage, Mitomycin administration & dosage, Ovarian Neoplasms pathology, Paclitaxel administration & dosage, Peritoneal Neoplasms drug therapy, Peritoneal Neoplasms secondary, Rats, Rats, Wistar, Triazines administration & dosage, Gemcitabine, Antineoplastic Agents administration & dosage, Infusions, Parenteral, Ovarian Neoplasms drug therapy
- Abstract
The study or antitumor effects of dioxadet, cisplatin, melphalan, paclitaxel, mitomycin C, cyclophosphamide and gemcitabine at intraperitoneal (i.p.) and intravenous (i.v.) administration as monochemotherapy and polychemotherapy in a rat model of ascitic ovarian cancer was carried out in 244 female Wistar rats. Ovarian cancer was transplanted i.p. at a number of 1 x 10(7) tumor cells. The drugs were administered once in 48 hours after ovarian cancer transplantation i.p. or i.v. for monotherapy--in maximum tolerated doses, for i.p. polychemotherapy--in half doses from maximum tolerated doses. Antitumor effects of the treatment were estimated in increase in median survival time (MST) compared to control rats who were administered saline i.p. At i.p. administration dioxadet, cisplatin and melphalan increased MST by 79%, 88% and 144%, respectively, while at i.v. administration these drugs didn't affect MST. Mitomycin C and paclitaxel had stronger antitumor action at i.v. administration increasing MST by 152% and 81%, respectively, while at i.p. administration these drugs increased MST by 35 and 45%, respectively. Combinations dioxadet + cisplatin, dioxadet + cyclophosphamide and dioxadet + paclitaxel at i.p. administration increased MST by 305%, 277% and 133%, respectively, and had additive antitumor action compared to mono-effects of these drugs. Gemcitabine and combination dioxadet + gemcitabine at i.p. administration didn't significantly affect survival of rats with ovarian cancer. Intraperitoneal monochemotherapy and polychemotherapy could be more effective in the treatment of peritoneal carcinomatosis from ovarian cancer compared to systemic administration of the drugs.
- Published
- 2015
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