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Your search keyword '"Arthropod Venoms toxicity"' showing total 6 results
Start Over Descriptor "Arthropod Venoms toxicity" Language russian
6 results on '"Arthropod Venoms toxicity"'

2. [Effect of divalent cations and pH changes on the presynaptic activity of the alpha-latrotoxin from the venom of the Lathrodectus mactans tredecimguttatus spider].

Author

Magazanik LG, Slavnova TI, Salikhov ShI, and Sadykov AS

Subjects
Animals, Black Widow Spider, Cations, Divalent pharmacology, Evoked Potentials drug effects, Hydrogen-Ion Concentration, Neuromuscular Junction drug effects, Ranidae, Arthropod Venoms toxicity, Calcium pharmacology, Magnesium pharmacology, Spider Venoms toxicity, Strontium pharmacology, Synapses drug effects
Published
1982

3. [Channel-forming action--a general property of venoms of spiders in the family Theridiidae (Aranei)].

Author

Kazakov I, Nenilin AB, Usmanov PB, and Tashmukhamedov BA

Subjects
Animals, Drug Interactions, In Vitro Techniques, Lipid Bilayers pharmacology, Membrane Potentials drug effects, Species Specificity, Spiders, Arthropod Venoms toxicity, Ion Channels drug effects, Spider Venoms toxicity
Abstract

The study of venom action of 10 spider species of Theridiidae family has shown that they cause the formation of the cation selective channels on the bilayer lipid membranes. This action does not depend on the species sex and age and it is the important diagnostic characteristic of the family. The channel-forming effect is due to the presence of the peptide with molecular weight about 5000 daltons in venoms of Theridiidae spider family.

Published
1985

4. [Action of the venom of the spider Argiope lobata on glutamatergic and cholinergic synapses].

Author

Usmanov PB, Kalikulov D, Shadyeva N, and Tashmukhamedov BA

Subjects
Animals, Grasshoppers, Neuromuscular Junction drug effects, Rana temporaria, Receptors, Glutamate, Arthropod Venoms toxicity, Glutamates metabolism, Receptors, Cell Surface drug effects, Receptors, Cholinergic drug effects, Receptors, Neurotransmitter drug effects, Spider Venoms toxicity
Published
1983

6. [Blocking action of Nephila clavata spider toxin on ionic currents activated by glutamate and its agonists in isolated hippocampal neurons].

Author

Kiskin NI, Kliuchko EM, Kryshtal' OA, Tsyndrenko AIa, and Akaike N

Subjects
Animals, Hippocampus cytology, Kinetics, Quisqualic Acid, Rats, Arthropod Venoms toxicity, Glutamates pharmacology, Hippocampus drug effects, Ion Channels drug effects, Kainic Acid pharmacology, Neurons drug effects, Oxadiazoles pharmacology, Spider Venoms toxicity
Abstract

The blocking action of the Nephila clavata spider neurotoxin was studied using the concentration clamp method in isolated neurons of the rat hippocampus. Crude venom JSTX blocked L-glutamate-, quisqualate- and kainate-activated ionic currents mediated by activation of the non-N-methyl-D-aspartate (non-NMDA) membrane receptors. Ionic currents elicited by all agonists were depressed by crude JSTX venom to 34-35% of its initial amplitude with no recovery during prolonged washing. An active fraction of JSTX venom blocked ionic currents almost completely, but its action was partially reversible. The concentration dependences of blocking kinetics allowed determining the rate constants of JSTX interaction with glutamate receptors. It is supposed that JSTX blocks the non-NMDA ionic channels in some of their open states and may be one of useful tools in further biochemical and electrophysiological characterization of the glutamate-mediated synaptic transmission.

Published
1989

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