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An analysis of the morphofunctional relationships between hypophysis and female mammary gland is performed in 146 patients aging between 8 and 25 years. Both organs are studied using various histological, histochemical, morphometric and statistical methods. It is established that hypophysis influences actively on the mammogenesis not only in the incipient (12-16 years) and late (22-25 years) periods of sexual maturation but at other age periods as well. However the degree and character of this pituitary influences on the mammary gland are not the same this being shown by the results of a correlation analysis of relationship between pituitary and mammary gland indices. This seems to be due to both a direct and indirect influence of pituitary hormones on the mammogenesis as well as to the individual variability of mammary gland responses on the mammogenic effects. In rare cases mammary gland reacts on the ordinary hormonal stimulus by the development of pathological process.

By means of a developed method of histotopographical sections cartograms, 146 preparations obtained from female persons at the age of 8-25 years have been studied. The organ is intensively developing not only at 12-16 years of age, but at 22-25 years, as well. A close correlation is noted at 10-11 years of age between the mammary gland mass and the degree of its parenchyma (glandular tree) development. Subsequently, the connection between these indices becomes essentially weaker. At the age of 15-25 years, according to the variability and standard deviation quantile classes reflecting stages in the organ formation (the degree of the glandular tree development), five types of the mammary gland are distinguished: weak, low middle, middle, high middle and high. During transition of the mammary gland from the weak to the high type, at first the glandular tree is intensively developing in the periphery and in the internal parts, and then in the external squares and in the center of the organ. The degree of uneven development in the glandular tree increases when the middle type is reached. Subsequently, it decreases up to the initial level.

Adrenal and mammary glands were investigated postmortem in 186 young or mature girls as well as in nulliparous women who suddenly died from injuries. The levels of mammary gland development was assessed with regard to their mass, the percentage of fibrous tissue and with regard to mathematically processed cartographic data on sectional histo-topography. Cytometry and karyometry of glomerular and reticulo-fascicular zones of adrenal glands were performed. A total estimation of adrenal glands activity was determined by a cumulative morphofunctional index. Morphofunctional relationship of adrenal and mammary glands was studied in females aged 8-25. The study revealed that accelerated development of mammary glands in 12-16-year-old persons was accompanied by increased activity of adrenal cortex while in those aged 22-25 it was followed by the enlargement of adrenal gland mass and size of fasciculo-reticular zone without any essential alterations of other morphofunctional parameters.