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INTRODUCTION. The problem of treating patients with peritonitis has always been and still remains relevant in surgery. Moreover, aspects of treating patients with tertiary peritonitis requiring repeated interventions are of particular importance. The OBJECTIVE of this work was to develop and evaluate the clinical effectiveness of a score-prognostic scale that allows to identify groups of patients with a high risk of persistent surgical infection in the abdominal cavity, in which a single intervention cannot be considered effective even despite the elimination of the primary surgical infection focus.METHODS AND MATERIALS. To achieve the goal, a correlation was evaluated between a number of factors and the likelihood of relaparotomy in a retrospective group consisting of 111 patients with secondary peritonitis. Based on the achieved data, score-prognostic scale for assessing the severity of peritonitis was developed, which allowed to formulate an algorithm of surgical tactics, which was used in the treatment of 109 patients. A group of 34 people with a high risk of tertiary peritonitis development was allocated from the number of patients – of which 20 patients had a total number of 39 planned surgical interventions.RESULTS. The use of the developed scale led to an increase in the total number of surgical interventions, however, reducing postoperative mortality by 1.7 times (p = 0.001) mainly due to improved survival rates in the group of patients with severe forms of peritonitis.CONCLUSION. The obtained results allowed to recommend the developed integral prognostic scale for assessing the severity of peritonitis for use in clinical practice.

Relevance. Surgical treatment of neoplasms, various genetic disorders and facial trauma often contribute to a violation of the general aesthetic perception of a person and the development of dysfunctions [1]. The main difficulty of reconstructive treatment in the maxillofacial area is a clear understanding of the anatomical and topographic landmarks and three-dimensional relationships of organs and tissues from each other. Purpose. Development of an algorithm for the use of various types of extraoral implants for various total facial defects. Materials and methods. The collection and analysis of clinical material was carried out in the Department of Maxillofacial Surgery on the basis of the Samara Regional Clinical Hospital named after V.I. V.D. Seredavina. From 2015 to the present, we have installed 104 extraoral implants of various designs for the rehabilitation rehabilitation of fifty patients suffering from total facial defects of various lengths. Conclusions. The analysis of our study showed that the use of extraoral implants of various designs for total facial defects of various lengths, taking into account individual anatomical and topographic features, the etiology of the total defect, has demonstrated its clinical effectiveness.

Objective: to compare recurrence rate, progression rate and recurrence-free survival in patients with high-risk non-muscle-invasive bladder cancer (NMIBC) after adjuvant intravesical chemotherapy (IVCT) with titanium glycerosolvate aquacomplex (TGA) versus intravesical BCG therapy.Material and methods. In a retrospective multicenter clinical study initially were included 126 patients with NMIBC. Of all 126 patients, 94 patients with high-risk NMIBC were selected and divided into 2 groups using a pseudo randomization with propensity score matching to minimize systematic differences in the process of forming groups. The treatment group (n = 55) consisted of patients with high-risk NMIBC who received a 6-week course of adjuvant IVCT with TGA. In the control group (n = 39) patients received an induction 6-week course of adjuvant intravesical BCG therapy, 19 (49 %) of 39 patients received maintenance therapy. Both methods were compared according to recurrence rate, progression rate and recurrence-free survival. Significance of difference was set at p Results. The compared groups of patients were well balanced in terms of clinical and morphological characteristics and the main risk factors for recurrence and progression of non-muscle-invasive bladder cancer, no significant differences were found between the groups (p >0.5). The recurrence rate in treatment and control groups was 33 % and 23 %, respectively (p = 0.31). The disease progression was observed in 1 (2 %) patient in the treatment group and in 4 (13 %) patients in the control group (p = 0.08). The median disease-free survival in both groups of patients was not reached at the time of analysis. Three- and five-year recurrence-free survival in the treatment group of patients were 71 % and 62 %, respectively; in the control group — 76 % and 72 %, respectively. There were no significant differences between recurrence-free-survival curves of the treatment and control groups (p = 0.58).Conclusion. Adjuvant IVCT with TGA has demonstrated a clinical effectiveness comparable to intravesical BCG therapy and it can be used as an alternative method of treatment in patients with high-risk NMIBC.

The paper reports the results of the analysis of modern notions about the economics of psychotherapy. Despite its great practical significance, this issue is insufficiently represented in Russian publications, arising mostly in foreign works. We consider two general concepts: efficiency and equity. The practice of research evaluation in psychotherapy distinguishes between (a) the efficacy of therapy — results of empirical psychotherapeutic research; (b) clinical (qualitative) effectiveness of therapy — results of psychotherapy in everyday practice; and (c) the notion of cost-effectiveness — a practical criterion; it characterizes the expenses for the achievement of a goal. Other expenses also ought to be taken into consideration. Additionally, we mark out progressive cost-effectiveness as a separate coefficient.

The review gives a contemporary notion about vital pulp minimally invasive diagnosis of temporary and permanent teeth. The latest information in Russian and foreign articles concerning new diagnostic methods that were proposed to increase diagnostic reliability is given in present review. The authors analysed advantages and disadvantages of diagnostic tools, studied their clinical effectiveness and made a conclusion about the possibility of predicting the status of pulses in the long term.

Aim. To evaluate the clinical effectiveness of the developed adaptive tools for mechanical treatment of wound surface and suturing of relaparotomy wounds. Methods. 55 patients aged 43 to 79 years after relaparotomy operated on for various acute surgical diseases of the abdominal cavity were treated. In the main group (n=22. average age 63.5±4.75 years) in uncomplicated and complicated course of the wound process after relaparotomy for treatment of the wound surface and wound closure, adaptive tools were used as proposed by the authors. In the comparison group (n=33, average age 62±6 years; p=0.98) traditional mechanical methods of wound defect sanation and wound suturing (simple nodal, 8-shaped and U-shaped sutures) were used. Monitoring of relaparotomy wound healing was performed using an ultrasound method. The analysis of postoperative local complications in the discussed groups of patients was carried out according to Clavien-Dindo classification. Results. In patients of the main group, the multiplicity of wound surface treatment decreased by 1.8 times compared to the comparison group. There were no cases of damage to the underlying tissues of the wound edges. Wound postoperative complications corresponded to severity grade I, II, and IIIa according to Clavien-Dindo classification: in the main group - 27.3% and in the comparison group - 54.5%. Suppuration occurred respectively in 9.1 and 33.3% of patients (p=0.049). Conclusion. The developed adaptive tools are safe and effective mechanical means of prevention of wound postoperative complications after relaparotomy.

Hypoalbuminemia and hypovolemia are independent risk factors for the development of multiple organ dysfunction, the main cause of death in critically ill patients. The use of a human albumin (HA) solution in complex of the fluid therapy affects both of these risk factors. However, more than 75 years of experience of HA use by the medical community and numerous clinical studies have proved its safety but did not lead to a consensus on the clinical effectiveness of its use. Thus, questions remain, and in which patients the use of HA is most appropriate. The authors of this review attempted to summarize the knowledge accumulated by the medical community on the use of HA in the practice of intensive care.

Aim. Comparative study of clinical effectiveness of doxazosin, tamsulosin and silodosin as monotherapy for patients with chronic non-inflammatory prostatitis. Methods. Outpatient medical records (OMR) of patients with the diagnosis of chronic non-inflammatory prostatitis who were treated in “The clinic of ambulatory urology” (Kazan) in 2012-2017, were analyzed: all 173 OMR of patients receiving doxazosin 1 mg QD for 30 days as monotherapy; all 150 OMR of patients receiving doxazosin 2 mg per day BID for 30 days as monotherapy; all 54 OMR of patients receiving doxazosin 4 mg per day BID for 30 days as monotherapy; all 77 OMR of patients receiving tamsulosin 0.4 mg QD for 30 days as monotherapy; all 36 OMR of patients receiving silodosin 8 mg QD for 30 days as monotherapy. Based on these OMR the “Clinical index of chronic prostatitis” (CI CP) was analyzed before the start of pharmacotherapy and 30 days after the beginning. According to the clinical index, the discrete sample was ordered containing the values of CI from 0 points (no complaints) to 50 points (maximal score - the most marked symptoms). Results. Before the beginning of the treatment every sample of patients is homogeneous and after 30-day treatment they lose homogeneity and tend to divide into several homogeneous samples. Conclusion. Clinical effectiveness of doxazosin, tamsulosin and silodosin in men with CNP varies in wide range, is poorly predictable, poorly explainable and needs further studies according to the principles of modern evidence-based medicine.

Представлены результаты пилотного исследования, основной целью которого явилась оценка эффективности и безопасности комбинированного применения α-адреноблокатора и ингибитора фосфодиэстеразы 5-го типа для лечения пациентов с симптомами нижних мочевых путей пожилого и старческого возраста. В исследовании участвовали 60 больных старше 50 лет, имеющие умеренные и тяжелые симптомы нижних мочевых путей, эректильную дисфункцию, умеренно выраженную инфравезикальную обструкцию, объем предстательной железы более 30 сми уровень простатспецифического антигена менее 4 нг/мл. Длительность лечения во всехгруппах составила 6 мес. Участники исследования были разделены на три группы, сопоставимые по возрасту, клиническим проявлениям и лабораторно-инструментальным показателям: пациенты 1-й группы ежедневно получали ингибитор фосфодиэстеразы 5-го типа, пациенты 2-й группы - α-адреноблокатор, 3-й группы - α-адреноблокатор и ингибитор фосфодиэстеразы 5-го типа. Проведенное клиническое исследование показало, что длительное комбинированное лечение симптомов нижних мочевых путей α-адреноблокатором и ингибитором фосфодиэстеразы 5-го типа у пациентов пожилого и старческого возраста оказалось эффективным, хорошо переносимым и практически не вызывало побочных реакций, существенно повышая качество жизни., The results of the pilot study are presented, the main purpose of which was to assess the effectiveness and safety of the combined application of α-adrenoblocator and type 5 phosphodiesterase inhibitor for the treatment of patients with symptoms of the lower urinary tract of old and old age. The study involved 60 patients over 50 years of age having middle-severe lower urinary tract symptoms, erectile dysfunction, moderately pronounced infravesical obstruction, prostate volume greater than 30 cc and prostate-specific antigen levels less than 4 ng/ml. The duration of treatment in all groups was 6 months. The study participants were divided into three groups, comparable in age, clinical manifestations and laboratory-instrumental indicators: Group 1 patients received type 5 phosphodiesterase inhibitor daily, group 2 patients - α-adrenoblocator, group 3 - α-adrenoblocator and type 5 phosphodiesterase inhibitor. A clinical study showed that long-term combination treatment of lower urinary tract symptoms α-adrenoblocator and type 5 phosphodiesterase inhibitor in elderly and senile patients proved to be effective, well tolerated and hardly caused side reactions, significantly improving quality of life., Успехи геронтологии, Выпуск 5 2021, Pages 927-933

Цель — изучить гемодинамическую и клиническую эффективность аутотрансплантации клеток костного мозга при критической ишемии конечности в сравнении с реваскуляризирующей остеотрепанацией и поясничной симпатэктомией. Материал и методы. Проведен анализ комплексного обследования и лечения 99 пациентов с критической ишемией нижних конечностей, разделенных на 3 статистически однородные группы. В первой группе выполнялась классическая РОТ, во второй — поясничная симпатэктомия, а в третьей — имплантация клеток аутологичного костного мозга. Гемодинамическая эффективность оценивалась по возрастанию реовазографического, лодыжечно-плечевого и фотоплетизмографического индексов, дистанции безболевой ходьбы, клиническая — по улучшению статуса пациентов по шкале Ruterford et аl. Результаты. Через 1 год объемный кровоток в ишемизированной конечности после имплантации аутоклеток костного мозга был выше в 2,1 раза, чем после реваскуляризирующей остеотрепанации и в 2,0, чем после поясничной симпатэкмии, магистральный кровоток, соответственно, в 1,6 и 1,4 раза, уровень микроциркуляции на 8,8% и 13,3%, дистанция безболевой ходьбы на 19 и 27м. Однолетняя клиническая эффективность классической реваскуляризирующей остеотрепанации составила 60,6%, поясничной симпатэктомии — 42,4%, а имплантация клеток аутологичного костного мозга — 94%. Конечность удалось сохранить у 26 (78,8%) в первой группе, у 30 (90,7%) больных во второй группе и у 32 (97%) — в третьей группе. Заключение: имплантация клеток аутологичного костного мозга при III стадии критической ишемии нижних конечностей у больных с отсутствием воспринимающего русла эффективна., The goal is to study the hemodynamic and clinical effectiveness of bone marrow cell autotransplantation in critical limb ischemia in comparison with revascularizing osteotrepanation and lumbar sympathectomy. Material and methods. The analysis of a comprehensive examination and treatment of 99 patients with critical lower limb ischemia, divided into 3 statistically homogeneous groups, was carried out. In the first group, classical revascularizing osteotrepanation was performed, in the second — lumbar sympathectomy, and in the third — implantation of autologous bone marrow cells. Hemodynamic efficacy was evaluated by increasing rheovasographic, ankle-brachial and photoplethysmographic indices, painless walking distance, clinical — by improving the status of patients on the scale of Ruterford et al. Results. After 1 year, the volumetric blood flow in the ischemic limb after implantation of autologous bone marrow cells was 2.1 times higher than after revascularizing osteotrepanation and 2.0 times higher than after lumbar sympathemia, main blood flow was 1.6 and 1.4 times, respectively microcirculation at 8.8% and 13.3%, painless walking distance at 19 and 27 meters. The one-year clinical efficacy of the classic revascularizing osteotrepanation was 60.6%, lumbar sympathectomy — 42.4% and autologous bone marrow cell implantation — 94%. The limb was preserved in 26 (78.8%) in the first group, in 30 (90.7%) patients in the second group, and in 32 (97%) in the third group. Conclusion: the implantation of autologous bone marrow cells in stage III critical ischemia of the lower extremities in patients with a lack of a perceptive bed is effective., Вестник Национального медико-хирургического Центра им. Н.И. Пирогова, Выпуск 1 2020

Introduction. In the initial stages of vasculogenic erectile dysfunction (ED), young men who are dissatisfied by administration of inhibitor 5-phosphodiesterase and/or intracavernous injections tend to deny surgical treatment. At the decompensated stage of ED penile prosthesis implantation presents the method of choice. However, currently there are new treatment approaches, the effectiveness of which is actively being investigated.Materials and methods. In article results of surgical treatment of 38 patients (25–48 years, mean age 34.3 ± 7.4 years) with vasculogenic ED are presented: 33 – venoocclusive ED, 5 – arterial insufficiency of the corpora cavernosa, 2 of them have hemodynamic and clinical signs of arteriovenous ED in subcompensation. The treatment included stenting or endovascular embolization with spirals.Results. Maximum follow-up was 4 years. Overall clinical effectiveness and subsequent sexual rehabilitation were assessed as sufficient based on the international index of erectile function before surgery was 10,5 ± 3,6 (9–13) and after surgery – 21,3 ± 4,2 (14–25) (p = 0,001).Conclusion. Application of these innovative technologies allows to perform a sexual rehabilitation of most patients with ED and to avoid phalloprosthesis implantation.

Objective: clinical and economic analysis of including of secukinumab (SEC) in the essential drug list (EDL) and Federal Reimbursement (ONLS) to ensure the availability of the drug to patients with ankylosing spondylitis (AS) at the expense of health. Material and methods. A budget impact analysis was used. Only cost of drugs was taken into account. Adalimumab (ADA) and infliximab (INF) were used for comparison. Basing on the calculated number of patients treated with these drugs in 2016 from the budget of health care system impact on 3-years budgets of State Guarantee Program (SGP) and ONLS was analyzed. The analysis scenario was based on the replacement of ADA and INF with SEC. Results. Expenditure of a 3-year therapy cycle with SEC amounted to 1.703 million rubles, which was 41.6% less than that with ADA (2.917 million rubles) and 57.7% less than that with INF (4.022 million rubles) in the same period. The budget impact analysis to estimate the cost of SGP demonstrated that the use of SEC during a 3-year period would result in a reduction in expenses by 51.2% (saving of 3.8 billion rubles). When SEC is used within the ONLS, its cost during 3 years will be reduced by 51.9% (savings of 1.9 billion rubles). Conclusion. The inclusion of SEC in EDL and ONLS is appropriately and economically justified, as it enables a substantial reduction in the expenditure of health care budgets to treat patients with AS and to maintain the clinical effectiveness of therapy.

The article presents an analysis of literature data assessing the state of the eye accommodative system based on objective accomodography techniques. There are the results of the evaluation after the excimer laser correction of myopia in individuals of visually intensive work and patients with refractive errors after cataract phacoemulsification. We conclude that the current development stage of ophthalmic diagnostic equipment allows to consider the issues of clinical effectiveness optical correction from the standpoint of objective indicators accommodative system of the eye in fundamentally new way to.

Metastatic melanoma remains a refractory disease. Great progress in therapy of metastatic melanoma patients has been made in the recent five years. Targeted immunotherapy – a selective effect on lymphocytes signal molecules - became a principally new trend in the drug therapy of tumors. Ipilimumab is the first drug of this class that demonstrated clinical effectiveness in metastatic melanoma patients. This article deals with a review of the latest data of internal studies and own clinical experience of ipilimumab application in metastatic melanoma patients.

Aim . Assessment of clinical effectiveness of trimetazidine MR (Preductal MR® , Les Laboratoires Servier) in patients with microvascular angina. Material and methods . Totally, 50 patients studied (mean age 55,16±3,82 y. o.) with microvascular angina primary (n=36) and secondary, related to arterial hypertension (n=14) and with remaining angina presentation of II-III FC at background of antianginal treatment of hemodynamic action. All patients, in addition to the performed treatment, were assigned with trimetazidine MR (TMR) with monthly control of antianginal efficacy during 6 months follow-up. Results . The treatment led to significant decline of angina attacks from 21,24±12,57 to 5,44±3,11 (p

Aim. To evaluate the possibility for the novel scores implementation in everyday management by perindopril/amlodipine in arterial hypertension patients of high and very high risk. Material and methods . Totally, 30 patients included, with AH of high and very high risk (12 males, 18 females) at the age 57,7±9,3 y.o., who, after the in-patient management of non-controlled AH by fixed combination of perindopril/amlodipine doses 10/5, 5/10, 10/10 mg, respectively, were treated and followed up for the next 2 years (with additional control in 1 year). During this period there was control of BP dynamics, intervisit variability of SBP/DBP, adherence to treatment, some of hemodynamics values (by EchoCG), lipids, creatinin and glucose of blood. Based on the proposed new expert systems (ASCORE scale, “vascular age” assessment scale) a clinician evaluated the dynamics of individual risk of cardiovascular complications and the “vascular age”. Results . The outpatients had stage III AH, of those grade 2 AH was diagnosed in 26,7%, and grade3 in 73,3%. In one year of treatment by perindopril/amlodipine in office visit the level of SBP/DBP was 162,8±7,7/91,5±2,4 mmHg; adherence to treatment — 63,4%. During the second year patients adhered to clinicians recommendation, with the target BP levels achieved (adherence 83,4%). There was significant decrease of intervisit variability of SBP (with the baseline 11,6±1,4 mmHg at in-patient and to 4,3±0,2 mmHg in 2 years of outpatient treatment; p

The article presents the results of research on the study of clinical effectiveness and impact on intestinal microbiocenosis dioctahedral smectite (Neosmektin®) of acute intestinal infectious of bacterial, viral, and mixt etiology. The clinical studies have shown that the additional inclusion in the complex therapy for children this enterosorbent has a pronounced detoxification and antidiarrheal effect, reducing the duration of the acute period of the disease increases sanitize effectiveness of the therapy against pathogens and contributes to the normalization of microbiocenosis intestine.

In 60 patients with moderate forms of the OCI «osmotic» (76.7%) and «invasive» (23.3%) such as diarrhea, aged 3—12 years, to evaluate the clinical effectiveness, impact on water and electrolyte metabolism, acid-base balance and intestinal microbiocenosis hypoosmolyarny solution with Lactobacillus rhamnosus GG «Regidron Bio» (30 patients) and hyperosmolarny solution (30 patients). It was found that in the group of patients receiving «Regidron Bio», in contrast to the hyperosmolarny solution, is rapidly disappearing symptoms of intoxication and exsicosis, abdominal pain, meteorism and liquid watery diarrhea. The average duration of the acute period is reduced from 4,06 ± 0,32 to 3,07 ± 0,27 day (P < 0,05). Already by the end of the 1st day of the beginning of rehydration, almost all patients (90%) are normalized malformations of blood electrolytes and glucose, hematocrit, and on the 2nd day, which took place in 80% of patients with metabolic acidosis. The addition of the «Bio rehydron» Lactobacillus rhamnosus GG facilitates, unlike hyperosmolarny solution indicator normalizing lg Lactobacilli (in 73.3%) and Enterococci (93.3%), but has no significant positive impact on the amount of Bifidobacteria and Escherichia coli.

Launching four intravenous antiepileptic drugs: valproate (Depakene and Convulex), lacosamide (Vimpat), and levetiracetam (Keppra) – into the Russian market has significantly broadened the possibilities of rendering care to patients in seizure emergency situations. The chemi- cal structure, mechanisms of action, indications/contraindications, clinical effectiveness and tolerability, advantages/disadvantages, and adverse events of using these drugs in urgent and elective neurology are discussed.

Проведено комплексне порівняльне клініко-імунологічне та мікробіологічне обстеження 30 хворих дітей із гострим фарингітом віком від 8 до 14 років із використанням препаратів Лізак і Хепілор, пігулок для розсмоктування та перорального спрея виробництва компанiї «Фармак» (Україна), у вигляді місцевої терапії в 20 дітей (основна група) і застосуванням спрея на основі сульфанiламiду в 10 дітей (контрольна група). Проведене дослідження показало, що препарати Лізак і Хепілор добре переносяться хворими, клінічно ефективніші, що підтверджується зниженням бактерійного обсіменіння з боку патогенних мікробів і грибків в основній групі. Визначення показників місцевого імунітету в ротоглотковому секреті пацієнтів виявило більшу ефективність препаратів Хепілор і Лізак у плані стимуляції продукції секреторного IgA порівняно з контрольною групою., Проведено комплексное сравнительное клинико-иммунологическое и микробиологическое обследование 30 больных детей с острым фарингитом в возрасте от 8 до 14 лет с использованием препаратов Лизак и Хепилор, таблеток для рассасывания и перорального спрея производства компании «Фармак» (Украина), в виде местной терапии у 20 детей (основная группа) и применением спрея на основе сульфаниламида у 10 детей (контрольная группа). Проведенное исследование показало, что препараты Лизак и Хепилор хорошо переносятся больными, клинически более эффективны, что подтверждается снижением бактериальной обсемененности со стороны патогенных микробов и грибков в основной группе. Определение показателей местного иммунитета в ротоглоточном секрете пациентов выявило большую эффективность препаратов Хепилор и Лизак в плане стимуляции продукции секреторного IgA по сравнению с контрольной группой., There was carried out a comparative comprehensive clinical-immunologic and microbiologic examination of 30 children with acute pharyngitis aged from 8 to 14 years ­using Lizak and Happylor, troche and oral spray, produced by «Farmak» (Ukraine), as a local therapy in 20 children (study group) and the use of spray based on sulfanilamide in 10 children (control group). The study showed Lizak and Happylor to have a good tolerance, greater clinical effectiveness, as evidenced by a decrease in bacterial contamination by pathogenic bacteria and fungi in the study group. Determination of local immunity indices in the oropharyngeal secretions of patients showed greater efficacy of Happylor and Lizak in terms of stimulation of secretory IgA production compared with the control group.

The paper analyzes the cost of treating 52 patients after carotid stenting (CS) and 50 after carotid endarterectomy (CE). It assesses their quality of life one year after treatment. The economic effectiveness of CS and CE as techniques for preventing stroke is shown. The cost of CS and CE is noted to become virtually equal when medical care is rationally organized. Whether surgical care for patients at high risk for stroke may be improved is analyzed.

Aim. To compare the effectiveness of different antihypertensive medications in the management of hypertensive crise (HC) in the early post-surgery period after carotid endarterectomy (CEE). Material and methods. The study included 39 patients (14 women, 25 men; mean age 65,6±6,6 years) hospitalised to the Cardiovascular Surgery Department of a major Moscow City hospital. All patients underwent CEE, with a HC developed in the early post-surgery period. All participants were divided into three groups: in Group I, HC was treated with nimodipine, while Groups II and III received enalaprilat and uradipil, respectively. Results. Intravenous administration of all three medications resulted in an antihypertensive effect. A significant reduction in blood pressure (BP) levels was observed after the administration of nimodipine and uradipil. However, nimodipine caused reflectory tachycardia, which was not observed in patients treated with uradipil. Conclusion. The results obtained are consistent that out of the three studied medications, uradipil appeared the most appropriate for the HC management in the early post-CEE period. It reduced BP levels without causing reflectory tachycardia or clinical hypotension, which confirms clinical effectiveness and safety of uradipil as a medication of choice for the urgent HC management.

Objective. To provide a rationale for a new method of neurostimulation — correction of the sympathetic nervous system based on the evolution of the electrical stimulation of the brain as a component of neurorehabilitation. Material and methods. Authors treated 16 patients with Korsakoff’s (amnestic) psychosis using this method. Results. Positive results were obtained in all patients. A typical case is described. Conclusion. The proposed method has a high therapeutic potential. © 2015, Media Sphera. All rights reserved.