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Introduction. The paper provides a complex system analysis of sociolinguistic projects of the "Language Unit of the Year" type in various linguistic cultures. There are several studies related to the topic of sociolinguistic "Word of the Year" projects, which focus on the activation of lexical and thematic groups within the calendar year. The relevance of this study is based on the lack of scientific papers that provide a comprehensive understanding of socio-cultural projects aimed at identifying the mechanisms and priorities of linguistic reflection through other semantic units. The purpose of the study is to record projects initiated by different countries in the period from 1971, the launch of the first project in Germany, to the present, to identify regularities and notable differences. The novelty of the research lies in the consideration of these sociolinguistic projects in a broader scope of linguistic cultures and the analysis of various semiotic units reflecting the influence of extralinguistic processes on linguistic consciousness.Materials and Methods. A critical analysis of databases and official pages of project sites was carried out, scientific publications and news articles of online publications were studied. The research used the methods of observation, comparison, generalization, analysis, synthesis and interpretation of data.Analysis. The regularities and distinguishing features of the development of the "Word of the Year" projects in the media discourse are studied. The projects under the study are systematized by languages, countries, and periods of implementation, the venues for posting information about the projects are identified and the organizations implementing the projects as well as their goals pursued are discovered.Results. The study has allowed us to record 71 projects of the "Language Unit of the Year" type, which have been carried out since the second half of the XX till the first decades of the XXI century in 29 countries of Europe, Asia, North and South America, Africa and Australia in 21 languages of the world. A meaningful change in the interest vector of the public, media actors and researchers towards other semiotic units, like gestures, hieroglyphs, numbers, emoji, and memes, has been revealed.

Objective. The purpose of the study is to develop a new method of analyzing seismic vibrations of seismically isolated structures.Method. The structure is modeled by a system with one degree of freedom with a nonlinear stiffness characteristic. In the absence of damping an analytical solution of oscillation equations on the phase plane is obtained. In this case the connection between speeds and displacements is accurate, and the law of uniformly variable motion is used to calculate displacements.Result. To take into account the attenuation, the law of change in mechanical energy at each integration interval is used.Conclusion. An example of calculating a seismically isolated system with a sliding belt and a spring with a linearly varying characteristic of stiffness is considered. The influence of dry friction and viscous damping on the displacement and acceleration of the system is analyzed.

The ongoing degradation of natural resources and climate change are the focus of close attention of the global and business community. Sustainable development goals have been formulated at the highest levels of global economic governance. However, the existing trends are not broken and, obviously, a critical mass of business on a global scale is being conducted contrary to the declared direction. The purpose of the study is to identify the necessary characteristics of the management system of a sustainable organisation and the driving forces of its development. To achieve this goal, the author used the method of conceptual analysis. The systematisation of the research results was carried out on the basis of the author’s concept of the architectonics of the organisation’s management system. The approaches used to the formation of sustainability and management models of sustainable organisations were analysed both in the form of cases and in an analytical form. As a result of the study, the author revealed the features of managing a sustainable business organisation. Fundamental among them is the leader’s set of values. It is a necessary factor for the existence of the organisation. This particular set of values the author calles “sustainability”, and it determines the proper functioning of other system elements: organisational culture, performance indicators and internal organisational standards. The most significant sign of the “sustainability” set of values influence on the management system are investment decisions. In particular, the most striking indicator of the sustainability of the management system is the priority of long-term goals over short-term ones in the choice of production technologies in the company’s development process. The study confirmed the need for an integrated approach to assessing the sustainability of business organisations. The results of the study were used to create a conceptual architectonics of a sustainable organisation management system.

The model of motivating delegation has been proposed and its justification by the results of recent studies in educational psychology, neurobiology and pedagogy has been presented. The actualization of the employee’s personal effectiveness lies in his internal, inherent and characteristic motivational model only for him. To build the model, the theory of self-motivation and the phenomenon of self-determination, recent discoveries in neurobiology have been used, a sequence of communication interactions between the director and the employee, which makes it possible to include the motivation of aspiration in the employee’s own motivational model, has been formulated. The main elements of the model are unconscious and conscious desires, and regulatory motives of both the leader and subordinate. Their hierarchy and interaction provide effective employee`s self-motivation in terms of setting the task, developing criteria for assessing the performance of the task. Motivating delegation allows you guaranteed to activate both the emotional part of the performer’s brain, which provides energy for the execution of the task, and the prefrontal complex, which is responsible for the thoughtfulness, creativity and consistency of the result and the process of the performance of the task.

There in the article the guideline for management system assessment is proposed on the basis of organizational horizontality concept developed by the author. The horizontal management system is defined as a complex of directed interconnection of adhoc culture and process based structure implemented in the client oriented management model. In this paradigm the horizontality indicator is shaped as an integrated index evaluating by Liebig’s law the minimum of parameters: client orientation, process structuring, adhocracy compliance of culture.

The analysis of the existing approaches to understanding of the involvement of personnel is presented in article. The model of the irresistible organization of the consulting company of «Deloitte» is considered. Developing the concept of a horizontal control system, the author offers the model of formation of the involvement, which is based on two groups of methods: structuring business on processes and formation of organizational culture, as result of participation style of leadership. The integrating element of model is feedback which has to be implemented both in the form of emotional support of employees, and in the formal system of assessment of their activity.

In the article a methodology of vertical management by objective and horizontal development mechanism combination is offered in the form of PDCA and DMAIC cycles kinematic pair. Author suggests to join these cycles in the A phase as a result of deviation analysis. Deviation in standard range launches the self-improvement cycle. Besides, this methodology is built on the organizational process structuring, client focused metrics as a basis for mutual assessment and horizontal control.

Virus technology organizational changes model is presented as an outcome of multidisciplinary research. The model consists of organizational virus structure, chang-es algorithm and immune instruments for process interruption. Author considers organiza-tional transformation virus as a value substance, shown out in attitude, behavior pattern, with information message as an envelope. Virus organizational transformation algorithm consists of three phases - penetration, assimilation, multiplication, focused on the opinion leader. Immunity appears in different existences: opinion leader personality, level of con-formity in organization and reflection as controlling and analytical tool. There are sever-al hypothesis for further researches presented in the article.

In the article a methodology of vertical management by objective and horizontal development mechanism combination is offered in the form of PDCA and DMAIC cycles kinematic pair. Author suggests to join these cycles in the A phase as a result of deviation analysis. Deviation in standard range launches the self-improvement cycle. Besides, this methodology is built on the organizational process structuring, client focused metrics as a basis for mutual assessment and horizontal control.

The analysis of the existing approaches to understanding of the involvement of personnel is presented in article. The model of the irresistible organization of the consulting company of «Deloitte» is considered. Developing the concept of a horizontal control system, the author offers the model of formation of the involvement, which is based on two groups of methods: structuring business on processes and formation of organizational culture, as result of participation style of leadership. The integrating element of model is feedback which has to be implemented both in the form of emotional support of employees, and in the formal system of assessment of their activity.

Epithelial-mesenchymal transformation in prostate gland cancer is a criterion of aggressive biological behavior of the tumor, but the clinical material is not sufficiently studied. The objective of the research was to study epithelial-mesenchymal transformation and its prognostic significance in benign pathology and prostate gland cancer. The absence of vimentin expression and the evident reaction of E-cadherin in the epithelium in benign pathology of the prostate glandwere revealed. The change in the expression of these markers in prostate gland canceroccur at the expense of low-differentiated forms and is characteristic of the high-risk group (p

Background. Stroma is a crucial factor in the growth and progression of prostate cancer. However, the morphological and molecular biological signs of cancer stroma that define prognosis of the disease have been investigated insufficiently. Objective. To identify relationships between morphological, immunohistochemical (vimentin, smooth muscle actin-α, MMP-9, collagen type IV) characteristics of the cancer stroma and criteria of aggressive clinical behavior, the risk of recurrence of prostate cancer. Metods. Stroma of the tumors was quantified in 112 patients treated with radical prostatectomy for clinically localized prostate carcinoma. Cancers were divided into three risk groups. Immunohistochemical study was conducted on the material of 33 cases of prostate cancer, 10 cases of normal prostate and 11 cases of atypical hyperplasia, in total 54 cases. The 2 test and Spearman rank correlation coefficient where used to compare the studied features. Results. Desmoplasia of prostate cancer occurred in 61.6% of cases, low, moderate and high grade in 29.5%, 25.9% and 6,2% respectively. Expression of vimentin, smooth muscle actin-α, MMP-9, collagen type IV in the cancer stroma where not uniform. Conclusion. Decrease of differentiation of prostate cancer from G1 to G2 was associated with increased degree of tumor desmoplasia, identified tendency to reduce desmoplasia level with decreasing differentiation to G3. Also revealed, the less differentiated tumor, the more expressed peritumoral reactive fibrosis. Absence of desmoplasia typical for low-risk prostate cancer, moderate and severe desmoplasia associated with cancers of the intermediate risk group. Stroma of prostate cancer with decreasing of tumor differentiation and growth of aggressive clinical behavior characterized by the disappearance of the collagen type IV, tendency to decrease smooth muscle actin-α and increase expression of vimentin because of increasing the number of tumor-associated fibroblasts and myofibroblasts. In the stromal cells with decreasing differentiation of prostate cancer and increasing the risk of recurrence has tended to increase of MMP-9 expression.

There in the article the guideline for management system assessment is proposed on the basis of organizational horizontality concept developed by the author. The horizontal management system is defined as a complex of directed interconnection of adhoc culture and process based structure implemented in the client oriented management model. In this paradigm the horizontality indicator is shaped as an integrated index evaluating by Liebig’s law the minimum of parameters: client orientation, process structuring, adhocracy compliance of culture.

Gravity phenomena related to the Earth movements in the Solar System and through the Galaxy are reviewed. Such movements are manifested by geological processes on the Earth and correlate with geophysical fields of the Earth. It is concluded that geodynamic processes and the gravity phenomena (including those of cosmic nature) are related. The state of the geomedium composed of blocks is determined by stresses with force moment and by slow rotational waves that are considered as a new type of movements [Vikulin, 2008, 2010]. It is shown that the geomedium has typical rheid properties [Carey, 1954], specifically an ability to flow while being in the solid state [Leonov, 2008]. Within the framework of the rotational model with a symmetric stress tensor, which is developed by the authors [Vikulin, Ivanchin, 1998; Vikulin et al., 2012a, 2013], such movement of the geomedium may explain the energy-saturated state of the geomedium and a possibility of its movements in the form of vortex geological structures [Lee, 1928]. The article discusses the gravity wave detection method based on the concept of interactions between gravity waves and crustal blocks [Braginsky et al., 1985]. It is concluded that gravity waves can be recorded by the proposed technique that detects slow rotational waves. It is shown that geo-gravitational movements can be described by both the concept of potential with account of gravitational energy of bodies [Kondratyev, 2003] and the nonlinear physical acoustics [Gurbatov et al., 2008]. Based on the combined description of geophysical and gravitational wave movements, the authors suggest a hypothesis about the nature of spin, i.e. own moment as a demonstration of the space-time ‘vortex’ properties.

Publications about the earthquake foci migration have been reviewed. An important result of such studies is establishment of wave nature of seismic activity migration that is manifested by two types of rotational waves; such waves are responsible for interaction between earthquakes foci and propagate with different velocities. Waves determining long-range interaction of earthquake foci are classified as Type 1; their limiting velocities range from 1 to 10 cm/s. Waves determining short-range interaction of foreshocks and aftershocks of individual earthquakes are classified as Type 2; their velocities range from 1 to 10 km/s. According to the classification described in [Bykov, 2005], these two types of migration waves correspond to slow and fast tectonic waves. The most complete data on earthquakes (for a period over 4.1 million of years) and volcanic eruptions (for 12 thousand years) of the planet are consolidated in a unified systematic format and analyzed by methods developed by the authors. For the Pacific margin, Alpine-Himalayan belt and the Mid-Atlantic Ridge, which are the three most active zones of the Earth, new patterns of spatial and temporal distribution of seismic and volcanic activity are revealed; they correspond to Type 1 of rotational waves. The wave nature of the migration of seismic and volcanic activity is confirmed. A new approach to solving problems of geodynamics is proposed with application of the data on migration of seismic and volcanic activity, which are consolidated in this study, in combination with data on velocities of movement of tectonic plate boundaries. This approach is based on the concept of integration of seismic, volcanic and tectonic processes that develop in the block geomedium and interact with each other through rotating waves with a symmetric stress tensor. The data obtained in this study give grounds to suggest that a geodynamic value, that is mechanically analogous to an impulse, remains constant in such interactions. It is thus shown that the process of wave migration of geodynamic activity should be described by models with strongly nonlinear equations of motion.

Among the morphological criteria of prognosis in patients with melanoma of the skin the most important ones are thickness, depth of invasion, ulceration of the tumor, the presence of microsatellites and metastases in regional lymph nodes, the severity of the proliferative activity of tumor cell invasion into blood vessels. The value of clinical, anatomical and cell-type variant of melanoma, the degree of pigmentation, the severity of her infl ammatory infi ltration, fi broplasia, signs of regression is controversial.