1. The anti-arrhythmia properties of the functional opioid agonist orphanin FQ (nociceptin).
- Author
-
Maslov LN, Krylatov AV, Lishmanov IuB, and Albrecht E
- Subjects
- Aconitine, Animals, Arrhythmias, Cardiac chemically induced, Arrhythmias, Cardiac drug therapy, Arrhythmias, Cardiac physiopathology, Calcium Chloride, Disease Models, Animal, Drug Evaluation, Preclinical, Electrocardiography drug effects, Epinephrine, Male, Rats, Rats, Wistar, Time Factors, Nociceptin Receptor, Nociceptin, Anti-Arrhythmia Agents therapeutic use, Opioid Peptides therapeutic use, Receptors, Opioid agonists
- Abstract
It was shown that the agonist of peripheral ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not connected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na(+) channels of the cardiomyocytes.
- Published
- 1999