1. [Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin].
- Author
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Gromova OA, Torshin IY, Gogoleva IV, Pronin AV, Stelmashuk EV, Isaev NK, Genrikhs EE, Demidov VI, Volkov AY, Khaspekov GL, and Alexandrova OP
- Subjects
- Amino Acids administration & dosage, Animals, Brain drug effects, Brain metabolism, Disease Models, Animal, Drug Synergism, Enkephalins administration & dosage, Galanin administration & dosage, Glutamic Acid toxicity, Intracellular Signaling Peptides and Proteins administration & dosage, Lithium Compounds administration & dosage, Male, Neuropeptides administration & dosage, Neuroprotective Agents administration & dosage, Orexins, Rats, Rats, Inbred Strains, Stroke drug therapy, Stroke pathology, Amino Acids pharmacokinetics, Enkephalins pharmacokinetics, Galanin pharmacokinetics, Intracellular Signaling Peptides and Proteins pharmacokinetics, Lithium Compounds pharmacokinetics, Neuropeptides pharmacokinetics, Neuroprotective Agents pharmacokinetics
- Abstract
Objective: To study the synergism between neuropeptides and lithium ions., Material and Methods: An experimental model of stroke (chronic bilateral occlusion of the common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination of micronutrient profile of brain substrates were used., Results: A complex of experimental studies revealed that the effect of cerebrolysin is influenced by the synergism between lithium ions and the neuropeptide contentof this drug. Pharmacokinetic synergism promotes the accumulation of lithium in brain tissues during cerebrolysin treatment. The existence of the pharmacokinetic synergism is evident from the potentiation of neuroprotective effects of the drug under the action of lithium ions established in the model of stroke., Conclusion: Lithium ions potentiate neuroprotective effects of cerebrolysin.
- Published
- 2015
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