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The inappropriate use of chemically synthesized antibacterial drugs, including fodder antibiotics, leads to a disturbance of the microbial ecosystems of the digestive canal and the appearance of pathogenic and opportunistic microorganisms of resistance to them. Therefore, in recent years, the use of animal-safe and environmentally friendly probiotics and phytobiotics has become widespread. Their action is aimed at the normalization of metabolic processes in the body and the mobilization of protective factors of the immune system, which is an effective alternative to traditional methods of prevention and treatment of diseases of the gastrointestinal tract. The article presents data on the influence of probiotic TOYOCERIN10⁹ and phytobiotic EXTRACT™ 6930 in combination with antibiotic (10% solution of enrofloxacin hydrochloride) on the clinical and haematological status of excised piglets, patients with gastroenteritis and their safety. The positive influence of probiotic and phytobiotic on the state of erythrocytopoesis was established. In particular, after treatment in experimental piglets, the number of erythrocytes decreased by 14.3% (P < 0.001) and 13.4% (P < 0.001), the hemoglobin content was 10.5% (P < 0.01) and 13.1% (P < 0.001) compared to the animals before treatment and reached the level of clinically healthy animals. The value of hematocrit in the blood of the exterminated piglets of all groups after treatment has reached the level of indices of clinically healthy animals. It is important to note that the use of probiotic and phytobiotic has positively influenced the leukocytopoiesis of piglets, as indicated by a decrease in the number of leukocytes in the blood of piglets in experimental groups by 26.9% (P < 0.001) and 25.4% (P < 0.001), compared with animal characteristics before treatment. Treatment of piglets using 10% solution of enrofloxacin hydrochloride, contributed to the improvement of the clinical condition of diseased animals in the 7–9th day, whereas in piglets, which were additionally used probiotic TOYOCERIN 10⁹ on 5–7th in the phytobiotic EXTRACT™ 6930 – on the 3–5th day. It was established that the use of probiotic TOYOCERIN 10⁹ and the phytobiotic EXTRACT™ 6930 in combination with the antibiotic increased the safety of experimental group piglets by 12.8% and 17.0%, as compared to the control group.