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The aim of the present study was to analyze clinical and cytokine features of recurrent respiratory system diseases in children with toxocariasis. 50 children aged 1 to 17 years (mean age - 10±5 years) with recurrent current of respiratory system disorders were studied. During the survey such clinical manifestations of the respiratory system disorders as obstructive bronchitis (50%), bronchial asthma (30%), pneumonia (10%) and laryngotracheitis (10%) have been revealed. Statistical analysis of the results was performed using the software package STATISTICA 6.1 (SNANSOFT). We have shown that the disorders of respiratory system in case of toxocariasis invasion often occur with severe intoxication and bronchial obstruction syndromes, temperature reaction, respiratory insufficiency and hepatomegaly. A prolonged course of the disease has been noted. "Inflammatory" indicators of general blood analysis, such as leukocytosis and increased of ESR have been recorded in patients with respiratory system disorders in children with T.canis infection significantly more often, significant "allergic" laboratory changes were in the form of eosinophilia. High average levels of pro-inflammatory IL-6, as well as low levels of IL 5 have been determined in children suffering from the respiratory system disorders and with toxocariasis invasion in the anamnesis. The obtained findings require further study.

A method has been developed for simultaneous determination of the activity of alpha-L-fucosidase (EC 3.2.1.51) and the beta-D-fucosidase activity induced by beta-D-galactosidase (IV, EC 3.2.1.23) in the serum. The paper presents data on changes in these enzymatic activities in the serum in an experiment, in acute hematogenous osteomyelitis and recurrent laryngotracheitis in children in pregnant females with gestosis and placental insufficiency.

Children with croup appearing in the presence of acute viral respiratory diseases (AVRD) show an increase in the IgM content in their blood sera during the first days of the disease followed by a decrease, and an increase in the IgG and IgE levels during the convalescence period. No essential shifts in the content of IgA have been observed. The total content of the immunoglobulins in children with croup, was lowered as compared to that in AVPD patients having no croup which is, probably, of a certain pathogenic importance. The increased content of IgE revealed in the blood sera of children with croup indicates the presence of an allergic component in this disease.