1. [Mechanisms of the respiratory activity of leptin at the level of the solitary tract nucleus].
- Author
-
Iniushkina EM, Merkulova NA, and Iniushkin AN
- Subjects
- Animals, Electromyography, Female, Hypercapnia physiopathology, Leptin administration & dosage, Leptin physiology, Male, Microinjections, Rats, Reflex, Stretch physiology, Respiratory Center drug effects, Solitary Nucleus drug effects, Leptin pharmacology, Respiration drug effects, Respiratory Center physiology, Solitary Nucleus physiology
- Abstract
In acute experiments on anaesthetised rats we investigated the effects of 10(-4) M leptin microinjected into the solitary tract nucleus on inspiratory-terminating Breuer-Hering reflex and ventilatory responses to hypercapnea. We found that the local administration of leptin into the area inhibited the inspiratory-terminating Breuer-Hering reflex. In contrast, ventilatory responses to hypercapnea were accentuated suggesting a modulatory effect of leptin on central chemoreceptors. The discovered physiological mechanisms are likely to play a key role for stimulating respiratory effects of leptin at the level of the solitary tract nucleus.
- Published
- 2009