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Background. During the implementation of the project "The relationship between the lipoprotein profile of the blood plasma and the parameters of the neuroendocrine-immune complex, and the influence of the factors of the Truskavets’ spa on them", we first divided observed cohort into 5 homogeneous groups that differed from each other by 6 discriminant variables. The purpose of this study is to identify the metabolic accompaniment of plasma lipoprotein profile in the same persons. Material and research methods. The object of observation were 41 volunteers: 20 women aged 30-76 years and 21 men aged 24-69 years without clinical diagnose but with dysfunction of neuroendocrine-immune complex and dysmetabolism. We estimated lipoprotein profile of plasma, determined the levels of the proinflammatory cytokines, parameters of lipid peroxidation as well as routine biochemical and paraclinical parameters. Results. The patients with increased, normal and decreased levels of Dobiásová’s&Frohlich’s Atherogenic Index of Plasma (D&FAIP) are characterized, together with levels of Triglycerides and HDLP Cholesterol by definition, by specific constellations of levels of IL-6, IL-1, Diene conjugates, Malondialdehyde, Katalase, Glucose, and Alanine aminotransferase (classification accuracy is 98.8%). A close canonical correlation was found between the parameters of the plasma lipoprotein profile, on the one hand, and metabolism and erythroon, on the other (R=0.920). Conclusion. Atherogenic, normal and anti-atherogenic blood plasma is characterized by specific levels of markers of inflammation, lipid peroxidation, cytolysis and erythroon.

Our study aimed to explore associated non-alcoholic fatty liver disease (NAFLD) and metabolic liver dysfunction influence on the severity of the new coronavirus infection COVID-19. Material and methods. The study design was a cross-sectional study. The research included 215 patients (39.50 % of men) aged 26–60 years who had undergone a new coronavirus infection COVID-19 at least two months ago. Participants were divided into three groups by severity of infection: mild (n = 99), moderate and severe (n = 116) by anamnesis. Hepatic steatosis index (HIS), body mass index (BMI), waist circumference, alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, systolic and diastolic pressure were calculated and abdominal ultrasound examination was done. Results. In the group with moderate and severe course of COVID-19, the proportion of patients diagnosed with NAFLDaccording to the HSI index was significantly higher compared to patients with mild coronavirus infection. Patients with mild COVID-19, who were diagnosed with NAFLD, had higher alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, BMI, systolic and diastolic pressure, waist circumference compared to patients without NAFLD. Similar differences persisted for patients with moderate and severe course. With the step-by-step exclusion of cardiometabolic parameters from the logistic regression model, the triglyceride content and BMI retained association with steatohepatosis according to ultrasound data, regardless of severity. When creating a similar model for the HSI index, significant correlation was shown for alanine aminotransferase activity in patients with mild COVID-19, for alanine aminotransferase activity and BMI – in patients with moderate and severe COVID-19. Conclusions. Patients with NAFLD have a more severe course of COVID-19. In addition, associations of the severity of COVID-19 with a combination of NAFLD and other cardiometabolic changes in the body, such as arterial hypertension, obesity, dyslipidemia, were revealed.

The article reflects the results of a study of the morphological composition of blood, indicators of metabolism and the content of hormones in the blood plasma of gonadectomized cockerels of the Adler silvery breed. In the experiment, 40 males were used at the age of 6 weeks, of which two groups were formed, a control and an experimental, 20 heads each. It was found that during the preparatory (leveling) period, the clinical state, morphological composition of blood and metabolic parameters in the experimental group of males did not differ from each other and were within the limits of their physiological values. There were also no differences in blood glucose concentration, protein content, triglycerol, cholesterol, uric acid, as well as the activity of alkaline phosphatase, alanine and aspartate aminotransferase in the blood plasma of cockerels in the experimental and control groups during the preparatory period. Gonadectomy of males by surgical intervention at the age of six weeks did not significantly affect the morphology of their blood on the third day, with the exception of ESR, the value of which in birds of the experimental group was 1.9 times higher than in the control. In gonadectomized males, the number of platelets in the blood decreased by 30.7% compared to the control, which indicates a decrease in platelet activity and is probably associated with their participation in blood coagulation processes in the body after gonadectomy. Other indicators of the morphological composition of blood, namely, the number of erythrocytes, leukocytes, lymphocytes, eosinophils and neutrophils in gonadectomized males did not change compared with the control. It was found that the concentration of glucose in the blood, as well as total protein and uric acid in the blood plasma of males who underwent gonadectomy on the third day of the research period were at the level of the values of the control group birds and corresponded to the physiological values of these parameters in clinically healthy birds. On the 125th day of the main period in gonadectomized males, the level of glucose and protein, as well as indicators of lipid metabolism, namely, the concentration of triglycerol and cholesterol in the blood plasma did not change, while the content of uric acid increased by 23.7% compared with the control. It was found that the content of cortisol in the blood plasma of gonadectomized males was 3.2 times lower, and testosterone 10.2 times lower than in the control. So, gonadectomy of cockerels does not affect the morphological composition of the blood, indicators of the metabolic status of the bird, but it helps to reduce the content of cortisol and testosterone in the blood plasma.

Background. Previous studies of the Truskavetsian Scientific School of Balneology have studied the effects of course use of bioactive water Naftussya - the main therapeutic factor of the spa - on plasma levels of thyroid hormones in males and females healthy rats and women with thyroid hyperplasia. In men with chronic cholecystitis, the immediate thyrotropic effects of a single use of Naftussya water have been studied. The aim of this study is thyrotropic effects of balneotherapy in Truskavets’ spa and their endocrine, vegetative and metabolic accompaniments in men and women with chronic cholecystitis and pyelonephritis. Materials and Methods. The object of clinical-physiological observation were 34 men (23-70 years) and 10 women (39-76 years), who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 7-10-day course of balneotherapy. The main object of study was the plasma level of Triiodothyronine. We determined also content in plasma Cortisol, Aldosterone, Testosterone and Calcitonin as well as the parameters of the HRV and metabolism. Results. We find in 16 patients (12 men and 4 women) inhibitory thyrotropic effect, in 22 (16 men and 6 women) neutral, and in 6 men only – enhancing effect of balneotherapy. Each variant of the thyrotropic effect is accompanied by characteristic changes in testosteronemia, calcitoninemia, parathyroid activity, Heart Rate, Baevskiy’s Activity Regulatory Systems Index, HRV-markers of vagal tone, Calciemia as well as VLD and LD lipoproteins Cholesterol plasma. Conclusion. Our data confirmed and supplemented the provisions on the multivariate effects of balneotherapy in the spa of Truskavets’ on the endocrine and autonomic nervous systems and metabolism of patients.

Introduction. Low plasma levels of 25-OH vitamin D (25(OH)D) have been associated with an increased prevalence of hypertension. The purpose of the research was to establish the association of clinical and metabolic parameters, Ca2+, parathormone and serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population. Material and method. 100 subjects with essential arterial hypertension (EAH) and target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved in the case-control study. Among them, 70,84% females, 29,16% males, mean age 57,86±7,81 yo. The control group consisted of 60 healthy individuals. All recruited patients were examined for heart rate, systolic and diastolic blood pressure (SBP, DBP); SCORE, BMI, waist and hip circumference (WC, HC); lipid panel, serum glucose and ionized calcium, 25(OH)D, parathormone levels were studied. Patients were divided into groups depending on total serum 25(OH)D concentration. Results. Low 25(OH)D concentration (5,0%. We found higher SBP and DBP by 9,12% (р=0,014) and 5,17% (р=0,047), higher BMI in men and women – by 20-28,11% (р

The results of the study of metabolic and clinical-radiological changes in patients of two groups with and without symptomatic epilepsy on the background of hemorrhages from ruptured arterial aneurysms are shown. The findings suggest that there is the development of hypoxic nature of violations with the activation of prooxidant reactions in both groups, however, in patients with symptomatic epilepsy was found a significant decrease in antioxidant activity of enzymatic and non-enzymatic cell protection systems with increasing the production of the proinflammatory cytokine TNF-alpha in contrast to the group of patients without epilepsy.

Actuality. The absence of physical activity (PA) harms the health and normal functional capacity of organs and is the main cause of most chronic diseases, including in patients with gallbladder disease (GBD) and after cholecystectomy (CC). Objectives of research. To analyze the causes and risk factors for the development of GBD. To analyze the effect of PA on the human body. To determine the directions of physical rehabilitation to improve the quality of life of people after cholecystectomy with concomitant pathology. Results of research. The risk factors for the development of GBD are low FA, overweight, obesity, smoking, female sex, childbirth before the age of 20, postmenopausal medication, diet (consumption of large amounts of calories from refined carbohydrates, animal protein and cholesterol and low content of vegetables and dietary fiber). CC is a trigger for the development of metabolic dysfunctions. FA deficiency and metabolic dysfunctions after CC lead to further development of comorbidities – a combination of factors, namely endothelial dysfunction in the form of insulin resistance, abdominal obesity, hypertension, dyslipidemia, is defined as metabolic syndrome (MS). Conclusions. Increasing FA and exercise training (ET) is an effective therapeutic strategy to improve endothelial function and, as a result, reduce the symptoms of cardiovascular disease (CVD), normalize lipid profile, slow the progression of diabetes mellitus (DM) and its consequences, reduce body mass index (BMI), blood pressure (BP), and the risk of stroke. The use of ET in people after CC with comorbidities should be individualized, taking into account age, gender, recovery period, lifestyle, and existing concomitant pathology. For effective positive changes, physical rehabilitation programs should last at least 12 weeks. The intensity and number of ET sessions for people after CC requires more thorough further study.

AIM: To study the somatic status of patients with varying degrees of hemophilia, the mechanisms of comorbidity from the results of studies of systemic microcirculation (MC), body composition, and key metabolic parameters/MATERIAL AND METHODS: One hundred and twenty hemophilia patients were examined. The authors studied their viscera; MC by laser Doppler flowmetry; body composition parameters by bioelectrical impedance; and blood cholesterol, albumin, and iron levels/RESULTS: The incidence of chronic diseases of the kidney, digestive system, and myocardium (from electrocardiographic findings), and liver was found to be proportional to the severity of hemophilia. The number of diseases per patient with mild, moderate, or severe hemophilia was 1.0±0.02, 1.5±0.02, and 2.5±0.03, respectively. Four and two systems were ascertained to be commonly affected in patients with severe and mild hemophilia, respectively. The investigators studied the comorbidity mechanisms that included changed systemic MC; a decreased perfusion associated with excess fat mass; evolving iron-deficiency; anemia; protein and mineral deficiencies; and a tendency to lower blood cholesterol levels, which reflected energoplastic wastes in hemophilia patients/CONCLUSION: The detection of comorbidity and mechanisms of its development in hemophilia makes it possible to improve the prevention of hemorrhage and visceral pathology in these patients and their quality of life.

The parameters of carbohydrate, protein, lipid metabolism and haemostasis were analysed in patients with Type 1 and 2 diabetes mellitus (DM-1, DM-2), who demonstrated the progression of micro- and macroangiopathy over the five-year follow-up period. Micro- and macroangiopathy progression was associated with haemostatic and metabolic disturbances, and also had some DM type-specific features. The disturbances of protein metabolism and haemostasis were as important as carbohydrate and lipid metabolism disturbances in predicting angiopathy progression.

Aim. The CORD Study compared effectiveness and tolerability of losartan and ramipril in patients with arterial hypertension (AH).Material and methods. The study included two groups, A and B. In Group A (n=4016; mean age 62,6+11,6 years; 53,1% women), the patients with blood pressure (BP) 3 months were switched from ACE inhibitors to losartan. At baseline and 1, 3, 6, and 12 months later, BP, heart rate, and biochemical parameters were measured; general blood assay and electrocardiography (ECG) were also performed. In group B (n=3813; mean age 60,5+12,2 years; 50,5% women), the patients with BP >140/90 mm Hg and no previous ACE inhibitor or angiotensin receptor blocker (ARB) therapy were randomly administered either losartan (50 mg/d; n=1887) or ramipril (5 mg/d; n=1926).Results. Group A demonstrated a decrease in BP — from 147,4+14,8/87,7+9,3 to 139,7+11,8/83,0+9,3 mm Hg (p

Aim. To compare the effects of two beta-adrenoblockers (BAB) – a generic carvedilol and metoprolol tartrate – on lipid profile, carbohydrate and purine metabolism parameters in patients with arterial hypertension (AH) and overweight or obesity (OW/O). Material and methods. The study included 320 patients, receiving carvedilol (n=160) or metoprolol tartrate (n=160) for 24 weeks. The effectiveness of antihypertensive therapy (AHT) was assessed by blood pressure (BP) dynamics at each visit and at the end of the study, comparing to baseline BP levels. Safety parameters included adverse event (AE) profile and biochemical parameter dynamics (lipid profile, glucose, creatinine (Cr), uric acid (UA), potassium (К+) and sodium (Na+)). Results. As early as at the first visits, a significant reduction in baseline levels of systolic and diastolic BP (SBP, DBP) was observed (р

Many studies indicate essential nature of food in maintaining health. An important factor is the consumption of a variety of essential elements, in particular vitamins. The aim was to determine the relationship of vitamin B12 levels in serum with metabolic parameters and the possibility of correction using gerodietetic meat pate. A total of 23 older people (60-80 years) were surveyed. We determined index mass body, waist circumference, biochemical indicators, vitamin B12 concentration in serum and food consumption (by frequency method). We also measured changes in these parameters under the influence of eating gerodietetic meat pate. The older adults often demonstrate deficient in vitamin B12 in the blood (about 65 % of the surveyed), which may be contributed both by its lack of dietary intake and malabsorption due to pathological changes in the digestive system. The content of vitamin B12 in the blood of the elderly has been closely linked to metabolic indicators and body mass. Using gerodietetic meat pate promoted not only the elimination of vitamin B12 deficiency, but also significantly improved the biochemical markers of protein, and especially lipid metabolism in the elderly (decreased low-density lipoprotein and high density lipoprotein increased).