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The goal of the study: to define theoretic correlation between BODE index in men with chronic obstructive pulmonary disease (COPD) and risk of osteoporotic fractures assessed as per bone mineral density and FRAX integral rate. Materials and methods. 125 men suffering from COPD smoking for a long period of time (the smoker index of 240 and time of smoking (packs/years) of 40) were included into the study. 10 year risk of osteoporotic fractures was assessed by FRAX software. The respiratory function was evaluated by the multi-module unit of MasterLab/Jaeger type. BODE index was defined in the patients. Results. The minimum level of BODE was observed in those suffering from COPD of the 2nd stage – 2.23 ± 0.88. In case of the 3rd stage of COPD BODE made 5.05 ± 1.19, in the 4th stage of COPD it made 7.0 ± 1.0. The maximum risk of fractures was detected in the patients of the 4th stage of COPD. The minimum risk of fractures was diagnosed in the patients of the 2nd stage of COPD. The confident correlations were found between BODE and bone mineral density (r = -0.71, p

The paper presents a model for predicting the protective efficacy of hormone replacement therapy (HRT) on the basis of a comprehensive evaluation of mineral density and metabolic activity of bone tissue. A positive correlation between the ratio of the differential rates of accumulation, representing the ratio between the standardized rates of accumulation of the lumbar vertebrae and femoral neck, and increase bone mineral density (BMD) of the lumbar vertebrae (L2-L4) using HRT. Determined inverse relationship between the initial level of the BMD and its growth against the backdrop of 12 months of use of HRT drugs. Established predictive model will allow a reasonably prescribe HRT that will enhance the efficiency of correction postmenopausal osteoporotic changes and reduce the side effects associated with the use of this group of drugs.

Enhanced core compression-distraction device reduces the time of treatment and rehabilitation of patients with injuries of explosives, it contributes to a more rapid and complete recovery of function of the hip joint. Using the author device, allows to make an early activation of the patient on the 2nd day after the operation, which contributed to the recovery of BMD 22 (78.6 %) of the 28 studied.

Objective. To study mineral density of bone tissue (BMD) in female pts with Sjogren's syndrome (SS) depending on menstrual statute and to evaluate the effect on it of long-term (for 5 years and more) therapy by prednizolone in dosage 2.5-5 mg/day on the state of bone tissue. Material and methods. 120 female pts aged 30-63 were examined by densitometry of low back and femoral neck with «Hologic 1000». Results. Comparison of obtained results with reference base data enabled to reveal negative effect of prednizolo- nc on bone tissue mineralization, clearly demonstrated at the beginning of glucocorticosteroid therapy in peri- menopausa. It was also noted that menopausa began earlier in pts taking prednizolone (at 43.9±5.1 y/o) as compared with untreated ones (at 4S.9±4.5 y/o); there were notable effect of the age of menopausa beginning on BMD and lower effect of the duration of postmenopausa. Rare (3.3%) development of osteoporosis in women of reproductive age associated with long-term non-correctable hypergammaglobulinemia and damage of renal tubular apparatus.

В статье проанализированы научные данные о роли кальция и витамина D в повышении минеральной плотности костной ткани и сокращении риска переломов. Показано, что высокие дозы витамина D и кальция могут быть рекомендованы всем женщинам как для лечения остеопороза, так и снижения риска остеопоротических переломов. Эффективной признана комбинация кальция 1 000–1 200 мг и витамина D не менее 800 МЕ в сутки. Обозначены перспективы исследования регенерации кости после остеопоротического перелома при сочетанном влиянии кальция и витамина D с другими антирезорбтивными препаратами., The article analyses scientific data concerning the role of calcium and vitamin D in increasing mineral density of the bone tissue and reducing the risk of fractures. It is shown that high doses of vitamin D and calcium can be recommended to all women both for treatment and reduction of the risk of osteoporotic fractures. The combination of 1,000–1,200 mg of calcium and at least 800 IU of vitamin D a day is considered to be effective. Prospects for studying bone regeneration after an osteoporotic fracture under combined influence of calcium and vitamin D with other antiresorptive drugs are indicated., У статті проаналізовані наукові дані про роль кальцію та вітаміну D у підвищенні мінеральної щільності кісткової тканини та зниженні ризику переломів. Показано, що високі дози вітаміну D і кальцію можуть бути рекомендовані всім жінкам як для лікування остеопорозу, так і зниження ризику остеопоротичних переломів. Ефективною визнана комбінація кальцію 1 000–1 200 мг і вітаміну D не менш ніж 800 МО на добу. Намічені перспективи дослідження регенерації кістки після остеопоротичного перелому за умов поєднаного впливу кальцію та вітаміну D з іншими антирезорбтивними препаратами.