1. [Informative value of multislice spiral computed tomography in identifying myocardial perfusion defect in patients with acute myocardial infarction].
- Author
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Veselova TN and Ternovoĭ SK
- Subjects
- Acute Disease, Aged, Angina, Unstable physiopathology, Contrast Media, Female, Heart Ventricles physiopathology, Humans, Male, Middle Aged, Multidetector Computed Tomography instrumentation, Multidetector Computed Tomography standards, Myocardial Perfusion Imaging instrumentation, Myocardial Perfusion Imaging methods, Acute Coronary Syndrome physiopathology, Multidetector Computed Tomography methods, Myocardial Infarction diagnosis, Myocardial Infarction physiopathology
- Abstract
Aim: To estimate the informative value of multislice spiral computed tomography (MSCT) in the diagnosis of myocardial infarction (MI)., Subjects and Methods: The study enrolled 171 patients with acute coronary syndrome (ACS), including 121 patients diagnosed with acute ST-segment elevation MI (STEMI), 19 with non-STEMI, and 31 with unstable angina. A comparison group consisted of 52 patients with stable coronary heart disease (CHD) and a control group comprised 17 patients without CHD. Intravenous contrast-enhanced MSCT was performed using a 64-spiral CT scanner. MSCT was carried out in the patients with ACS on days 3-5 of the onset of a pain attack and in the other patients electively. It was redone in 44 patients with acute MI (AMI) 6 months after a primary examination., Results: Left ventricular (LV) perfusion defect was imaged in 94.3% of the patients with AMI and in 10% of those with unstable angina. LV contrast defects were undetectable in the patients from the stable CHD and control groups. The sensitivity, specificity, prognostic value of a positive result, negative prognostic value of a result, and accuracy of MSCT in the diagnosis of MI were 94.3, 97.1, 97.8, 92.5, and 96.70%, respectively. In the patients with STEMI, myocardial perfusion defect was larger and transmural perfusion defect was more common than in those with non-STEMI. Comparison of the values of myocardial perfusion defect size and myocardial density according to the data of primary and repeat MSCT revealed no statistically significant differences: 2.0 (0.50; 5.45) and 1,8 (0.35; 5.00) cm3 (p = 0.15); 41.7 +/- 10.2 and 46.1 +/- 12.2 HU, respectively (p = 0.07)., Conclusion: Contrast-enhanced MSCT allows visual and quantitative assessments of myocardial perfusion defect in patients with ACS. Myocardial perfusion defect from MSCT data suggests previous MI with a high probability, but does not permit the determination of the duration of the disease.
- Published
- 2013