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Your search keyword '"Muscimol antagonists & inhibitors"' showing total 1 results
Start Over Descriptor "Muscimol antagonists & inhibitors" Language russian
1 results on '"Muscimol antagonists & inhibitors"'

1. [Tetrodotoxin competition with muscimol for the gamma-aminobutyric acid receptor].

Author

Kuznetsov VI, Tonkikh AK, Karanova MV, and Sadykov AA

Subjects
Animals, Binding, Competitive drug effects, Brain metabolism, Muscimol antagonists & inhibitors, Rats, Solubility, Tetrodotoxin antagonists & inhibitors, Tritium, gamma-Aminobutyric Acid metabolism, Muscimol metabolism, Oxazoles metabolism, Receptors, GABA-A metabolism, Tetrodotoxin metabolism
Abstract

It has been shown that tetrodotoxin inhibits GABA-receptor binding of muscimol with solubilized membranes of the rat brain in a competitive manner, with the inhibition constant amounting to about 3 nM. Muscimol has been also demonstrated to competitively inhibit 3H-tetrodotoxin binding with the same drug.

Published
1985

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