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Your search keyword '"Mycobacterium leprae pathogenicity"' showing total 3 results
Start Over Descriptor "Mycobacterium leprae pathogenicity" Language russian
3 results on '"Mycobacterium leprae pathogenicity"'

1. [Reproduction of experimental leprous infection in mice with a preliminary modelling of failure of the mononuclear phagocyte system].

Author

Vishnevetskiĭ FE, Iushin MIu, Aiupova AK, and Urliapova NG

Subjects
Animals, Immunologic Deficiency Syndromes microbiology, Immunologic Deficiency Syndromes pathology, Leprosy immunology, Leprosy microbiology, Leprosy pathology, Male, Mice, Mice, Inbred CBA, Mycobacterium leprae pathogenicity, Time Factors, Disease Models, Animal, Immunologic Deficiency Syndromes immunology, Leprosy etiology, Leukocytes, Mononuclear immunology, Phagocytes immunology
Abstract

CBA mice with induced insufficiency of mononuclear phagocyte system (MNPS) were inoculated intraplantar with M. leprae in a dose of 1 X 10(4). A significantly accelerated multiplication of M. leprae was noted in the sites of inoculation with the development of a generalized infections process and appearance in 6 months after inoculation of lepromatous structures in spleen, liver and other internal organs as compared with the animals with unchanged MNPS. The data obtained suggest that insufficiency in macrophage component of cell-mediated immunity might underline the sensibility to leprosy infection.

Published
1988

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