1. NEDD9 scaffolding protein expression as a negative prediction marker in non-small cell lung cancer (NSCLC)
- Author
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M. V. Tikhomirova, V. V. Barmin, Yu. A. Topchu, A. M. Mazitova, E. Yu. Ratner, A. G. Sabirov, Z. I. Аbramova, and A. Ya. Deneka
- Subjects
немелкоклеточный рак легкого ,общая выживаемость ,беспрогрессивная выживаемость ,поддерживающие белки ,nedd9 ,маркеры-предикторы ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The purpose of the study was to assess the prognostic significance of a scaffolding NEDD9 protein in patients with non-small cell lung cancer (NSCLC). NEDD9 (Neural precursor cell expressed, developmentally down-regulated 9) is a scaffolding protein in many intracellular protein cascades, such as PI3K-AKT-mTOR, Ras-ERK, which play key roles in tumor progression. several studies define the regulatory role of NEDD9 in progression of several solid cancers, including non-small cell lung cancer (NSCLC), however its role as a prediction biomarker is minimally assessed. Materials and methods. In the current study quantitative immunohistochemical (IHC) approach was utilized to characterize NEDD9 expression in a cohort of NSCLC primary tumor samples (n=16), and correlative statistical analysis was performed between NEDD9 expression and a set of patients’ clinical and pathological characteristics. Results of the IHC analysis were validated using broader TCGA RNAseq dataset (n=566). Results. The study demonstrated significant difference between the expression of Nedd9 in stage iii tumors versus stages II and IV (p
- Published
- 2022
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