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The study has indicated the relatively frequent occurrence of secondary tumors in hematological patients. These tumors may be both synchronous and metachronous. They generally occur in different periods after chemo- and/or radiotherapy. A secondary hematological tumor that is unilinear or heterolinear more commonly develops. The authors have not found a correlation between the intensity of the therapy and the occurrence of a secondary tumor and the impact of elderly age on the shorter occurrence of a secondary pathological process.

The paper describes a clinical observation of closure of sphenoidal sinus defect and plastic repair of dura mater by using orbital tissues after removal of a tumor from the medial portions of the middle cranial fossa, which spread into the orbit and sphenoidal sinus, in complete irreversible loss of visual function, ophthalmoplegia and ptosis in a patient with skull soft tissue hypotrophy due to multiple operations and radiation therapy and hence unsuitable for displacement and closure. This observation shows it possible to use orbital soft tissue for repair of the base of the skull, in cases when integumentary cranial tissues are impossible to use as a plastic material due to their hypotrophicity. At the same time severe dysfunctions, such as blindness and ophthalmoplegia enable orbital tissues to be employed without significantly deteriorating any functional and cosmetic effect.