1. [Reversion of sedation and general anaesthesia--agonist-antagonist technique].
- Author
-
Matveeva OB and Mizikov VM
- Subjects
- Adolescent, Adult, Aged, Anesthesia Recovery Period, Anesthetics, General adverse effects, Anesthetics, General pharmacokinetics, Blood Pressure drug effects, Cholinergic Antagonists adverse effects, Drug Therapy, Combination, Female, Heart Rate drug effects, Humans, Hypnotics and Sedatives administration & dosage, Hypnotics and Sedatives adverse effects, Hypnotics and Sedatives pharmacokinetics, Male, Middle Aged, Narcotic Antagonists adverse effects, Neuromuscular Blocking Agents administration & dosage, Neuromuscular Blocking Agents adverse effects, Neuromuscular Blocking Agents pharmacokinetics, Young Adult, Anesthesia, General methods, Anesthetics, General administration & dosage, Cholinergic Antagonists administration & dosage, Deep Sedation methods, Hypnotics and Sedatives antagonists & inhibitors, Narcotic Antagonists administration & dosage, Neuromuscular Blocking Agents antagonists & inhibitors
- Abstract
Objective: To study an expediency and efficacy of application of different reverses drugs (naloxone, flumazenil, neostigmine, galantamine, sugammadex) either their separate or combined using., Methods: We studied 119 patients underwent endoluminal endoscopic procedures and surgeries on trachea-bronchial tree and intestines under sedation or general anaesthesia., Results: The article deals with conceptual approaches to the reversal of residual effects of opioids, benzodiazepine sedation and neuromuscular block (the so-called agonist-antagonist technique)., Conclusions: A reversion of neuromuscular block without using of antagonists' combination does not provide complete recovery of psychomotor and cognitive functions for rapid socialization of patients after anaesthesia.
- Published
- 2014