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Your search keyword '"Pancreatic Ducts enzymology"' showing total 2 results
Start Over Descriptor "Pancreatic Ducts enzymology" Language russian
2 results on '"Pancreatic Ducts enzymology"'

1. [Starting mechanisms of trypsinogen activation in acute pancreatitis].

Author

Shabanov VV

Subjects
Acute Disease, Animals, Calcium metabolism, Cathepsin B metabolism, Enzyme Activation, Free Radicals metabolism, Humans, Oxygen metabolism, Pancreas pathology, Pancreatic Ducts enzymology, Pancreatitis pathology, Trypsin metabolism, Pancreas enzymology, Pancreatitis enzymology, Trypsinogen metabolism
Abstract

Early events critical for the development acute pancreatitis are considered. The possible initiating mechanisms of intracellular trypsinogen activation are discussed. Essential attention is paid to the role of cathepsin B, intraacinar [Ca2+] increase and free radicals generation in the premature zimogen activation. It is demonstrated, that the trypsinogen activation alone may not be sufficient to cause acinar cell injury. Some factors, other than active trypsin, play a main role in the pancreatic damage and in the development of systemic complications of acute pancreatitis.

Published
2003

2. [Functional distinction of secreting pools of the pancreas and participation of the pancreatic ductal system in the development of the pancreatic secret properties].

Author

Korot'ko GF, Voskanian SE, Gladkiĭ EIu, Makarova TM, and Bulgakov VA

Subjects
Animals, Dogs, Kinetics, Pancreas anatomy & histology, Pancreas enzymology, Pancreatic Ducts enzymology, Pancreatic Ducts metabolism, Pancreas metabolism
Abstract

Acute experiments on dogs with separate secretion of the pancreatic enzymes, either stimulated or inhibited, from two lobes of pancreas, and investigation into the character of kinetics of the secretion from 5-7 ductal pools of the pancreas showed the functional specifics, with the device of ductal valves and microdepot of a secret of the pancreas ductal system playing an important role. The conclusion is made that the final secret of pancreas removed to the duodenum is a product of a secret-motor activation of non-equipotentional microregions of the gland, being the components of an intervisceral dynamical mosaic.

Published
2002

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