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Effect of Russian 3-oxypiridine and succinic acid derivatives (emoxipin, reamberin and mexidol) on duration of behavioral despair in mice in forced swimming test (by Porsolot) and tail suspension test (by Steru) was investigated. In addition impact assessment of studied medicinal products (MP) on animals' behavior in open field test was performed. Amitriptyline and alpha-lipoic acid were used as reference drugs. It was determined that single delivery of all studied drugs in optimal doses eqvivalent to therapeutic range for human reduces lasting of behavioral despair in Porsolot and Steru tests. This effect of reamberin, mexidol and alpha-lipoic acid indicates their antidepressant action unrelated to stimulatory activity, as far as these MPs like amitriptyline show sedative action in open field test. Reduction of behavioral despair due to effect of emoxipin in relative low doses was associated with increase of mice activity in open field test and so it can't be considered to be antidepressant action per se. Increase of emoxipin dose leads to progressive decrease of its stimulatory effect impact in behavioral despair reduction and induce antidepressant effect in the setting of sedation.

A study was made of changes in the amplitude and percentile contribution of respiratory waves and slow waves of heart rhythm (SW1 with a period of 8-14 s and SW2 with a period of 14-60 s) in 13 patients with panic attacks (PA) in the lying position after the 3-day monotherapy with the beta-blocker propranolol, alpha-blocker phentolamine and diazepam. Propranolol normalized baroreflex regulation of arterial pressure and raised SW1. Phentolamine, producing an analogous effect, enhanced sympathoadrenal activation and the rate of PA, reducing RW. The amplitude of SW2 that correlated with emotional tension and anxiety fell only as a result of the administration of diazepam. The latter drug did not influence the baroreflex (via SW1) and vagal (via RW) mechanisms of regulation.

The paper treats of the data on the treatment of 69 patients with vegetative crises (panic attacks) with amitriptyline and clonazepam by the double blind placebo control method. The efficacy of amitriptyline was 77% versus 42% (placebo); that of clonazepam was 84% versus 35% (placebo). The clinical predictors of the placebo efficacy and of each of the drugs in the treatment of the conditions in question have been established.