1. [Glutamate lonotropic Receptors: Structure, Localisation, Function].
- Author
-
Perfilova VN and Tyurenkov IN
- Subjects
- Action Potentials physiology, Cardiovascular Physiological Phenomena, Central Nervous System cytology, Cognition physiology, Humans, Long-Term Potentiation physiology, Neurons cytology, Neurons physiology, Nociception physiology, Peripheral Nervous System cytology, Protein Subunits chemistry, Receptors, AMPA chemistry, Receptors, Kainic Acid chemistry, Receptors, N-Methyl-D-Aspartate chemistry, Respiration, Central Nervous System physiology, Peripheral Nervous System physiology, Protein Subunits physiology, Receptors, AMPA physiology, Receptors, Kainic Acid physiology, Receptors, N-Methyl-D-Aspartate physiology
- Abstract
The data on the structure, location and function of ionotropic glutamate receptors is shown. These include NMDA-, AMPA-, kainate and orphan receptor, activation them ensures the formation of an action potential. The ionotropic receptors are present in the CNS and peripheral organs. There are a large number of them allosteric modulators, agonists and antagonists. NMDA- and AMPA-receptors play a key role in the origin and manifestation of long-term potentiation. When NMDA- and AMPA-receptors are hyperactivity excitotoxicity arises--a pathological process that causes damage and death of neurons. The ionotropic glutamate receptors are involved in the regulation of mental functions, respiratory, sensory, cardiovascular, nociceptive, etc. g. systems.
- Published
- 2016