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Waking noncurarized rabbits were subjected to defensive conditioning. Subcutaneous injections of GABA derivative conditioning. Subcutaneous injections of GABA derivative Phenibut (nootropic) (40 mg/kg) were shown to accelerate the acquisition of internal inhibition, to decrease and stabilize the time of intersignal reactions, to increase the heart rate, and to decrease the respiration rate. At the early stage of conditioning, Phenibut facilitated movements in response to a conditioned stimulus. Consequently, when using nootropics for normalization and improvement of the CNS operation, one should take into account their effects not only on excitation but also on inhibition in the CNS, as well not only on cognitive processes but also on the somatic state. The findings confirm the involvement of GBABergic neurotransmitter system in the internal inhibitory conditioning.

The influence of oral diazepam administration (10 mg) on interhemispheric proactive and retroactive interferential inhibition during detection of test verbal signals was tachistoscopally studied in eight healthy right-handed subjects, in conditions of forward and backward contralateral masking according to the scheme of double blind investigations. Strengthening of effects of forward and backward contralateral masking was revealed which is considered as a testimony to participation of GABA-ergic inhibitory systems in the mechanisms of interhemispheric proactive and retroactive interferential inhibition.

Two phenomena of universal biological significance are described, namely, disinhibition of the functional structures and disintegration of the biological systems. Both phenomena are interrelated: disintegration of systems releases its component functional structures from inhibition, and the uncontrolled activity of the disinhibited (hyperactive) functional structures leads further disintegration. These phenomena are initiated by a lesion. Disinhibition of the functional structures manifests itself differently in various systems, but it is always based on the deficiency of biological control. The formation of hyperactive structures as determinants which transform physiological systems into pathological ones, as well as derepression of subsequent links of the cellular genetic apparatus are particularly important in these phenomena. Some tissue processes have been investigated with regard to the latter. Under normal conditions the controlled disinhibition (facilitation) or derepression may be physiologically important and necessary for functioning. In the paper, a class of pathological processes termed as regulation diseases resulting from disturbances in the function regulation is defined.