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Background. Metabolic syndrome is one of the most dangerous risk factors of cardiovascular and endocrine diseases development and mortality due to them, especially among young people. Aims: Our purpose was to study the prevalence of the metabolic syndrome, combinations of its components in indigenous and non-indigenous inhabitants of Mountain Shoria. Materials and methods. During the period since 2012 to 2015 we have examined the inhabitants of the villages of Mountain Shoria: Ust-Kabyrza, Orton, Sheregesh by a continuous method on the basis of a name list. All the participants were examined by a cardiologist, an endocrinologist and a general practitioner, also a waist circumference and arterial blood pressure were measured. Specific diagnostic methods included an estimation of blood glucose level, triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) in blood serum. Results. All the subjects (460 persons) were divided into age (18–39 years, 40–59 years, 60 years and older), ethnic (the Shors and the non-Shors) and gender (men and women) groups. Generally, the metabolic syndrome was diagnosed in 40.2% of inhabitants of Mountain Shoria. Metabolic syndrome (MS) was presented in 12.4% of indigenous men and in 47.8% of non-indigenous examined men (р=0.00001). MSwasrevealedin 36.8%, of Shor-women and in 60.7% of non-Shor women (р=0.00002). The most common variant of 3-component MS was abdominal obesity + arterial hypertension + hyperglycemia and the rarest was – abdominal obesity + TG + hyperglycemia. The most common variant of 4-component MS was a combination of abdominal obesity + hyperglycemia + arterial hypertension + HDL-C, the rarest was abdominal obesity + arterial hypertension + TG + HDL-C. Different variants of 3-component and 4-component MS occurred with similar frequency in all age groups of the Shors and non-Shors. Conclusions. Generally MSoccurred more frequently in non-indigenous inhabitants than in indigenous inhabitants. Only in women of young age group this pathology was revealed with the similar frequency among both ethnic groups. Among all the inhabitants of Mountain Shoria the most frequent clinical variant of 3-component MS was a combination of abdominal obesity + arterial hypertension + hyperglycemia and of 4-component variant – a combination of abdominal obesity + hyperglycemia + arterial hypertension + HDL-C.

Purpose. To evaluate the effect of the changed living conditions during the last decade, the prevalence of obesity as a risk factor for cardiovascular disease among residents of Mountain Shoria. Materials and methods. During the periods since 1998 till 2002 and since 2012 till 2015 in field conditions by continuous method we examined 1215 and 774 inhabitants correspondingly in the outlying hard-to-reach villages of Mountain Shoria. About half of them was represented by indigenous inhabitants - Shors, the other half by more than 95% was represented by Russians. The examination included: clinical examination, measurement of height, body mass, waist circumference (WC), hip circumference (HC), body mass index, WC/HC index. Obesity diagnosis was made in accordance with WHO criteria (1997). Results. During all the examination periods women of non-indigenous nationality revealed obesity more often (3.9% of obesity cases among Shor women, 31.3% cases among non-Shor women over the period since 1998 till 2002 (р=0.0001), 7.3% of obesity among indigenous female inhabitants and 31.4% among non-indigenous women over the period since 2012 till 2015 (р=0.0001)). Over the last 15 years a number of individuals with obesity and overweight has significantly increased: the percentage of men with obesity (over the period since 1998 till 2002 - 0.8% of Shor and 2.4% of non-Shor men had BMI≥30 kg/m2 (р=0.072), as compared to 2012-2015 period - 7.3% of Shor and 27% of non-Shor men had obesity (р=0.00001). Among Shor women the percentage of obese individuals increased significantly at the age of 40-49, 60-69 and over 70 years old. In representatives of male indigenous population the number of obese individuals increased significantly at the age of 40-49 years old, in non-Shor men - at the age of 18-29, and 30-39 years old. Conclusion. Regardless of gender and ethnicity the number of individuals with overweight and obesity increased significantly among the inhabitants of Mountain Shoria, as well as the value of WC/HC index, especial among Shor women.