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Start Over Descriptor "Stavudine analogs & derivatives" Language russian
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1. [Isosteric triphosphonate analogues of dNTP: synthesis and substrate properties toward various DNA polymerases].

Author

Skoblov AIu, Semeniuk AN, Murabuldaev AM, Sosunov VV, Viktorova LS, and Skoblov IuS

Subjects
Adenosine Monophosphate chemistry, Animals, Dideoxynucleotides chemical synthesis, Humans, Stavudine chemistry, Substrate Specificity, Adenosine Monophosphate analogs & derivatives, DNA-Directed DNA Polymerase chemistry, Deoxyadenine Nucleotides chemistry, Dideoxynucleotides chemistry, Organophosphonates chemistry, Stavudine analogs & derivatives
Abstract

Isosteric triphosphonate derivatives of 2',3'-dideoxy-2',3'-didehydroadenosine and 3'-deoxy-2',3'-didehydrothymidine and their beta,gamma-substituted analogues were synthesized. Their substrate properties toward a number of reverse transcriptases of the human immunodeficiency and bird myeloblastosis viruses, human DNA polymerases alpha and beta, and the Klenow fragment of Escherichia coli DNA polymerase I were studied.

Published
2007
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