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BACKGROUND: development of obesity and obesity related conditions are directly associated with eating disorders and psychological state. There is increasing focus on the assessment the characteristics of these indicators in men with subcutaneous and central fat distribution, which are associated with various hormonal and adipokine mechanisms that effect on parameters of metabolism and eating behavior. AIMS: to study the characteristics of the psychologycal state, eating behavior and their relationship with hormonal and adipokine status in men with different fat distribution. MATERIALS AND METHODS: a single-center, cross-sectional study of 99 men aged 27 to 68 years was performed. 4 groups of men were formed after anthropometric examination. Group 1 (comparison) consisted of men with normal body weight. Group 2 consisted of overweight men, class I obesity and lower subcutaneous fat distribution (SFD). Group 3 consisted of overweight men, men with class I obesity and abdominal fat distribution (AFD); group 4 - men with class II obesity and class III obesity AFD. Eating behavior were determined with DEBQ questionnaire, severity of anxiety-depressive disorders were investigated with the Hospital Anxiety and Depression Scale; body image satisfaction was assessed with body image questionnaire. Serum glucose, triglycerides, insulin, leptin and adiponectin were estimated. RESULTS: it was shown, that men with AFD had severe metabolic disorders: hyperglycemia, hypertriglyceridemia, hyperinsulinemia and insulin resistance, hyperleptinemia and hypoadiponectinemia, than men with SFD. Men with AFD had an external type of eating behavior, with sever expressed depressive disorders and body image dissatisfaction. Men with SFD had an emotional type of eating behavior and higher body image satisfaction. A comparative analysis between men from 3 and 4 groups with AFD showed that in group 4 in men had higher hyperleptinemia and insulin resistance and there are no differences in severity of eating disorders, anxiety and depression between the groups. CONCLUSIONS: adipose tissue topography is associated with the psychophysiological, metabolic, hormonal and adipokine characteristics that underlie the development of primary obesity in men.

BACKGROUND: Currently, obesity is one of the most global problem in the world. Redundant accumulation of adipose tissue accompanied by metabolic disorders including high secretion of leptin may lead to an increased risk of gestational complications. AIMS: To assess the level of leptin in pregnant women’s blood serum depending on their body weight and the character of content of adipose tissue in different terms of gestation. MATERIALS AND METHODS: We investigated 211 women with single pregnancies, which came in natural cycles and finished with urgent parturitions. All of them got anthropometric study, assessment of adipose tissue’s weight by bioimpedanceometry, character of fat deposition by ultrasound investigation of adipose tissue, determination of the level of whey leptin at 10–14, 24–28, 36–38 weeks of pregnancy. RESULTS: Established, that the level of leptin increases in proportion to pregestational body mass index from the first trimester. Women with excess body mass and with obesity had higher concentrations of leptin all over gestation, than women with normal body mass (р

Background: With the increasing prevalence of obesity in Iraq, an increasing trend towards better physical fitness has emerged among young adults. At the same time, an increasing number of dietary supplements is offered to improve fitness and shed the extra weight. Conjugated linoleic acid (CLA) is commonly used for such purpose. Aim: The current study was designed to test if CLA can actually accelerate weight loss when combined with dieting and moderate exercise and to examine its effect on anthropometric measures of obesity. Subjects & methods: Sixty young males enrolled willingly in the study and were put on a low-carbohydrate low-fat diet and moderate high intensity interval exercise (HIIT) program. Forty of them were given CLA (1000 mg/day) for 8 weeks while the remaining twenty served as control group. Body mass index (BMI), waist/hip ratio (WHR), sagittal abdominal diameter (SAD) and body adiposity index (BAI) were recorded as baseline and again after 4 and 8 weeks. Results: The CLA-treated group showed significantly greater reduction in all four measures by the end of the study. The control group had significant but less decrease in BMI & SAD but not in WHR or BAI. The percent change difference between the first and second four weeks of the study also showed statistical difference among the two groups and for different measures. The most significant finding was that SAD dropped more rapidly during the first 4 weeks of the study indicating a preferential loss of visceral fat. Oppositely, WHR dropped during the second half of the study indicating loss of more abdominal fat stores. Discussion: Regardless of the mode of action of CLA, its accelerative effect in weight loss is augmented by the combination with dieting and physical activity. It also corresponds to the natural body preference to losing the more metabolically active visceral fat prior to switching to the loss of subcutaneous fat. Whether or not this effect is sustainable requires further study.

There are many methods of the body composition assessment, but the most relevant are computed tomography and magnete-resonance tomography. Composition of the body shows the rate of fat amount and distribution in metabolic syndrome (MS) patients. It is known that MS increases the risk of atherosclerosis, arterial hypertension, type 2 diabetes, with further significant increase of cardiovascular morbidity and mortality. MS is associated with subclinical damage of internal organs; and the role of abdominal obesity is high. However, till recently there is no unified understanding of the role of visceral and subcutaneous fat.

Aim of the research: to educe the morphological features of fat tissue of epiploon and subcutaneous fat cellular tissue of people with normal body mass index. Methods and results. With a help of histological, histochemical and morphometrical methods the morphological features of fat tissue of epiploon and subcutaneous fat cellular tissue were studied in 12 persons with normal body mass index. The authors have established the presence of white fat tissue in epiploon and subcutaneous fat cellular tissue which is characterized by certain morphometrical features: area and perimeter of adipocytes of fat tissue in subcutaneous fat cellular tissue were significantly larger in comparison with the corresponding parameters in epiploon; the area and perimeter of adipocytes nuclei of both tissues were not significantly different; number of adipocytes in fat tissue of epiploon was significantly larger in comparison with the fat tissue in the subcutaneous fat cellular tissue; it’s revealed that fat content in adipocytes of fat tissue of epiploon is significantly larger in comparison with adipocytes of the subcutaneous fat cellular tissue. Parenchymal-stromal coefficient was significantly larger in subcutaneous fat tissue; trophic index was significantly larger in fat tissue of epiploon. Conclusion. Obtained data can be used as scientifically reasonable norms in scientific and practical activity.

The diseases of skin and subcutaneous tissue represent consist medical and social problem due to their high prevalence. In the case of chronic course, dermatosis result in long-term temporary incapacity for work, disability and deterioration of quality of life of patients. The purpose of the study was based on analysis of scientific publications to assess level, structure and dynamics of morbidity of population, territorial features of prevalence of diseases of skin and subcutaneous tissue and risk factors for their occurrence. The scientific review of studies in Russian and English was carried out using information portals and platforms eLIBRARY.ru, PubMed, Web of Science and Scopus for the period 2010-2022. The selection included 47 publications that assessed levels of primary and general morbidity of population with diseases of skin and subcutaneous tissue and its dynamics over certain periods of time, as well as territorial features of prevalence of these diseases in the Russian Federation and risk factors of development of skin diseases. Many studies demonstrated decreasing in primary and general morbidity of population with diseases of skin and subcutaneous tissue. The rate of decreasing was more pronounced in 2018-2022. The level of primary and general morbidity differs significantly by Okrugs and Subjects of the Russian Federation, including particular nosologies. It is determined that there is wide spread of incidence rates across territories. The large proportion of publications reflects prevalence of psoriasis in population. The authors proposed measures of to improve registration of skin diseases and to decrease corresponding morbidity of population.

The aim of present analysis was to investigate the correlations between the ultrasound parameters of subcutaneous and premesenteric fat and cardiovascular risk factors, anthropometric and biochemical parameters and behavioral characteristics in a population sample. The object of the study was a random population-based family sample in Octyabrsky district of Novosibirsk (324 men and women aged 18–64 years old). Ultrasound examination of heart, vessels and abdomen was conducted, the thickness of subcutaneous (SF) and premesenteric (PF) fat was measured in every second subject, totally in 163 subjects. In studied population sample of men and women aged 25-64 the value of ultrasonic PF and SF thickness strongly correlated between themselves and were associated with the anthropometric parameters (body mass index, waist-hip ratio, skinfold thickness) measured by standard methods. Ultrasonic indicator of PF thickness positively correlated with the level of blood pressure, proatherogenic lipid parameters (total cholesterol, triglycerides, LDL-choleaterol), blood glucose and plasma insulin levels and was inversely related to the level of HDL- cholesterol. Ultrasonic indicator of SF thickness was similarly correlated with blood pressure and insulin level, but in contrast to the thickness of the PF was not associated with the lipid parameters and blood glucose level.

Aim of investigation. To study parameters of body composition in operated patients with colorectal cancer. To assess interrelation between received data and treatment results (mortality and postoperative morbidity rate). Material and methods. Original study included data of 113 patients, that were operated in surgical clinic of Federal State-Funded Institution «Medical-andrehabilitational center» of Ministry of Health and Social Development the Russian Federation from February, 2009 to November, 2011. Overall there were 66 women and 47 men, aged 30 to 87 years. The mean body mass index (BMI) was 25±4 kg/m2. Obesity was diagnosed in 12 patients before operation, in 5 body weight deficit was found. Body composition data, including amount of skeletal musculature, subcutaneous fat tissue and visceral fat, estimated at single axial native CT-image at the level of 3rd lumbar vertebra (L3) by specialized software. Sarcopenia was detected as a state at which the volume of sceletal musculature is at the range below 2 standard deviations from the mean level for healthy adults. Differences were considered as statistically significant at p

Objective: To retrospectively analyze the results of histological examination of subcutaneous adipose tissue (SAT) biopsy specimens versus the diagnostic value of drugs manufactured by different procedures., Material and Methods: The investigators selected and analyzed the results of biopsy studies with the simultaneous production of two different types of tissue specimens (squashed native specimens, sections from the paraffin blocks) from the abdominal SAT biopsy specimens obtained from 118 patients. In each case, the tissue specimens were stained with Congo red and examined in polarized light, concurrently using the positive control. The criterion for amyloid was the ability of congophilic deposits to birefringence with a characteristic luminescence spectrum when examined in polarized light., Results: Compared to the sections from the paraffin blocks, the native specimens were shown to be of high diagnostic value. The advantages of different types of tissue samples made from SAT biopsy specimens were formulated., Conclusion: The SAT biopsy specimens are characterized by the minimal risk to a patient and by the easy way of sampling and are a frequent subject for screening biopsies. In addition to the type of amyloid, the volume, quality, and method of processing the biopsy specimen are responsible for the diagnostic value of SAT examination. The study of squashed native specimens stained with Congo red is most informative when using polarized light.

The use of nutriceutics (hexavit (multivitamin) or the natural concentrated product (NCP) Atlant from the raw plant material) and the parapharmaceutic lyophilized bifidumbacterin to enhance natural resistance in the subjects of an organized collective body in skin and subcutaneous fat infections (SSFI) (furuncul, abscess, phlegmons, pyodermas) showed the increasing bactericidal activity of the skin, normalized composition of colonic microflora, decreases in primary morbidity from appealability rates and in SSFI morbidity. When the NCP was taken, prophylactic efficiency was higher, which was likely associated with its increased concentrations of antioxidant vitamins (A, E, and C) and minor components.