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We studied the peculiarities of functional activity of peripheral blood leukocytes in different etiological variants and clinical forms of tick-borne infections in 629 children aged from 1 to 14 years. The decrease of biocide potential of neutrophils was accompanied by most severe clinical manifestations. The analysis of changes in defensin levels in different clinical forms of tick-borne infections revealed the most significant changes in cases of mixed infection. The dynamics of functional activity of leukocytes during the cycloferon immunotherapy reflected the effectiveness of recovering process in biocide potential regardless of the infection etiology. The main advantage of immunotherapy is the possibility of its use in the complex treatment before the serologic confirmation of the diagnosis regardless of disease etiology.

In the first type of mutual relationships the ixodid ticks expose an evident pathogenicity to vertebrate hosts (tick toxicoses) and in the second type the hosts expose a resistance on a base of organism immune system activisation in a response to blood sucking. In the third type of relationships an interaction between the ticks and hosts have a dynamic character (tolerability of host). The first type of relationships leading to a selective elimination of hosts according to our opinion means a comparatively youth of relationships. The third type represent ancient and long term relationships. The second type probably having been widely spread in a historical past occupies an intermediate position. Depending upon areal the ticks of the same type expose different degree of the pathogenicity. Even an acquired resistance of the host does exist in natural conditions, it is a transient phenomenon.