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Currently, there is an acute problem of implementing investment projects for integrated development of territories. Important indicators of the effectiveness of integrated development projects for state authorities and investors (developers) are investment value and investment value management efficiency. The purpose of this work is to develop an algorithm that allows you to calculate the true investment value and competently manage projects for the integrated development of the territory for the purposes of housing construction. The object of the research is the investment value of the land plot for the integrated development of territories for housing construction purposes. The subject of the research is the mechanisms of managing the investment value of the integrated development of territories for housing construction. Baseline data are studies of various authors to determine the effectiveness of investment value management. Conducted research in this area allowed the authors to determine the main stages of managing the investment value of the integrated development of the territories and the factors that make up the investment value. The main result of the research is a compiled algorithm of an economic-mathematical model for managing the investment value of a land plot in integrated land use projects for housing construction. This algorithm consists of 10 stages. In the first two stages, information is collected about the land plot. At the third and fourth stage, calculations of land, town planning balances, technical conditions, and costs are made. The fifth one calculates the possible profit, and the sixth one predicts the possible risks. Based on previous studies (stages 1-6), at stage 7, a preliminary assessment of the investment value is made. At stages 8-10, the investment cost is agreed upon, the possibility of raising budget funds is assessed, and management decisions are made. Following the steps of the algorithm, it is possible to calculate the investment value of the land plot. The practical significance of the results obtained is connected with the possibility of their use for making sound management decisions in the field of land and property relations, in particular, for solving problems related to the management of integrated development projects by territories.

The purpose of the current work was to study the winter wheat varieties artificially infected with the North Caucasian population of brown rust to identify a damage degree. The study was carried out in two stages on two sets (8 and 10) of varieties with different level of resistance to the pathogen. The trials have established a high damage degree of rust on susceptible varieties, which resulted in productivity decrease from 16.3 to 32.2%. Among the varieties with the maximum damage degree, there was identified the most resistant variety ‘Tarasovskaya 29’ which, when completely (100%) damaged by the disease, showed a minimum productivity decrease, no more than 10.6%. The varieties being poorly susceptible to brown leaf rust reduced the productivity from 11.2% to 20.7%. The smaller indices of productivity decrease among this group were shown by the variety ‘Spartak’. Among the five varieties that showed moderate leaf rust damage, there were different degrees of productivity decrease. The variety ‘Donskaya Yubileynaya’ artificially infected with brown rust, showed a minimal productivity decrease and its structural elements, and it could be identified as the leaf rust resistant variety like the variety ‘Tarasovskaya 29’. When predicting the brown leaf rust epiphytoty, the susceptible and half-resistant wheat varieties require obligatory protection with fungicides.

В статье представлена характеристика уровня сформированности коммуникативных универсальных учебных действий первоклассников., This article presents the results of a diagnostic observation of the formation of communicative universal learning actions of primary school children in inclusive practice. The article defines the terms “diagnostics” and “communicative universal learning actions” as key research concepts; demonstrates the development of simulators for the diagnostics of communicative universal learning actions in pupils of grade 1; presents the characteristic of the level of formation of communicative universal learning actions of elementary school children and the dynamics of their progress in mastering communicative universal learning actions (KUUD). In the study, the following methods were used: analysis of psycho-pedagogical literature; entrance and final testing; and quantitative and qualitative processing of experimental data., Специальное образование, Issue № 3 (59), Pages 73-84

Aim. To suggest a new perspective on chronic alcohol intoxication by means of investigating the associated severe multiple organ pathology, which frequently becomes the cause of lethal outcome in patients suffering from drunkenness and alcoholism.Key points. The empirical basis of the study consisted in the analysis of autopsy results obtained from 1,115 corpses of persons having abused alcohol during their lifetime. In addition, 800 experiments on rats were carried out. As a result, a concept of alcoholic disease (AD) is proposed. AD is defined as a condition, in which chronic ethanol intoxication leads to the development of morphological changes in organs and systems: from minimal injuries of the microcirculatory pathway to a multiple organ pathology showing signs of alcoholism. AD pathogenesis is demonstrated to undergo 3 major stages, from (1) episodic alcohol intoxication, through (2) drunkenness and to (3) alcoholism. It is noted that, while the morphological changes are considered to be reversible during the first two stages, they become irreversible at the stage of alcoholism.Conclusion. It is concluded that the forms of the disease that involve the described morphological changes in organs and systems should be primarily treated by physicians, not by psychiatrists and narcology practitioners who are only capable of dealing with the psychological aspect of the problem.

The use of fractional technologies for post-harvest treatment and processing of grain heap delivered from field with further special purpose use of grain fractions leads to a significant increase in grain production efficiency. (Research purpose) Developing a fractional technology for post-harvest treatment and processing of grain with crushing and preservation of feed grain fraction and designing a technological line and machines for it. (Materials and methods) The authors have analyzed the technological level and developed a fractional technology for grain post-harvest treatment and processing by crushing with subsequent preservation of the feed grain fraction. They have offered a technological line and presented the design and technological parameters of the corresponding technical means (МЗУ-20Д - grain cleaning universal machine, МПО-30ДФ - preliminary grain cleaning machine with fractionation, ПЗД-3,1, ПЗД-10 – two-stage grain crusher). (Results and discussion) The authors have designed, manufactured and tested a universal grain-cleaning machine МЗУ-20Д. It efficiently cleans grain material coming from the field after its threshing by combine harvesters, and divides it into fractions: seed and feed grain – 60-70 percent, waste material - up to 10 percent, grain fodder - up to 40 percent. Further on, the grain is sent for crushing (for wet grain), followed by preservation and hermetic storage of the products obtained before their feeding to animals. Tests have shown that the developed feed preparation machine efficiently performs the technological process. The authors have developed a two-stage grain crusher (ПЗД-3,1), performing the crushing of grain material in two stages by three rollers, followed by preservation (for wet grain) of the feed grain fraction. (Conclusions) It has been established that the use of the new fractional technology and equipment contributes to an increase in grain cleaning productivity – by 30-40 percent, and the estimated annual economic effect of the renovation is 400,000 rubles. The estimated annual economic effect of the use of the two-stage grain crusher (ПЗД-3,1) has proved to be more than 60 thousand rubles, and the level of production intensification has increased by 26 percent as compared to the MURSKA crusher produced in Finland.

OBJECTIVE. The objective is to develop differentiated tactic of surgical treatment of patients with postoperative sternomediastinitis.MATERIAL AND METHODS. The work is based on the results of treatment of 56 patients. The classification of sternomediastinitis by El Oakley & John E. Wright (1996) was used. Depending on the time of the plastic surgery, the patients were divided into two groups. I group (n = 32) consisted of patients got the plastic stage of the operation immediately after the sanative surgery. II group (n = 24) consisted of patients got the operative treatment in time-divided two stages. Patients of both groups were comparable in terms of key indicators. RESULTS. Recovery was achieved in 31 (96 %) patients in I group and in 21 (88 %) patients in II group. The duration of follow-up was between 6 months and 3 years.CONCLUSION. With the fifth type of sternomediastinitis according to El Oakley & John E. Wright (1996), it is advisable to perform a sanative and plastic surgery in the first stage. With the I–IV type of sternomediastinitis, it is advisable to separate the operation and conduct it in 2 stages.

To compare the clinical manifestations of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrAxSpA).A Moscow early spondyloarthritis cohort has now included 132 patients with axial spondyloarthritis, of whom 69 patients who have been followed up at least 12 months are to be involved in a preliminary analysis. The mean age at the time of inclusion in the study was 28.1±5.5 years; the mean disease duration was 24.7±15.8 months; 63 (91.3%) patients were HLA-B27 positive; 41 and 28 included patients were diagnosed with AS and nrAxSpA, respectively.Men were significantly more in the AS group than in the nrAxSpA group (58.5 and 32.1%, respectively; p=0.05). The patients of the two groups did not differ in main clinical parameters (the presence of arthritis and enthesitis), disease activity (BASDAI, ASDAS-CRP) and functional status (BASFI). All indicators of inflammatory activity decreased nearly 2-fold in both groups after 12 months of follow up. In 7 (25%) patients with nrAxSpA, radiologically detectable sacroiliitis (SI) developed over 12 months and the diagnosis of AS was verified. Among them, 2 (28.5%) patients had initially active SI detected by magnetic resonance imaging (MRI); 4 (57.1%) had chronic SI, and 1 (14.4%) had no pathological MRI changes.Due to the fact that the clinical manifestations of AS and nrAxSpA are comparable, it can be assumed that the latter is an early stage of AS.Цель исследования. Сопоставление клинических проявлений анкилозирующего спондилита (АС) и нерентгенологического аксиального спондилоартрита (нр-аксСпА). Материалы и методы. В московскую когорту КоРСар (Когорта Раннего Спондилоартрита) в настоящее время включены 132 больных аксиальным спондилоартритом (аксСпА), из которых в предварительный анализ вошли 69 больных, наблюдавшихся не менее 12 мес. Средний возраст на момент включения в исследование составил 28,1±5,5 года, средняя продолжительность заболевания - 24,7±15,8 мес, 63 (91,3%) больных позитивны по HLA-B27, 41 пациент включен с диагнозом АС, 28 - с нр-аксСпА. Результаты. В группе АС мужчин было достоверно больше, чем в группе с нр-аксСпА (58,5 и 32,1% соответственно; р=0,05). По основным клиническим параметрам (наличию артритов и энтезитов), активности болезни (согласно индексам BASDAI, ASDAS СРБ) и функциональному статусу (индекс BASFI) пациенты двух групп не различались. Через 12 мес наблюдения все показатели воспалительной активности уменьшились почти в 2 раза в обеих группах. У 7 (25%) пациентов с нр-аксСпА за 12 мес развился рентгенологически выявляемый сакроилиит и подтвержден диагноз АС. Изначально среди них у 2 (28,5%) человек имелись выявляемые при магнитно-резонансной томографии (МРТ) признаки активного СИ, у 4 (57,1%) - хронического СИ, а у 1 (14,4%) не выявлено патологических изменений по данным МРТ. Заключение. В связи с сопоставимостью клинических проявлений АС и нр-аксСпА можно предположить, что последний является ранней стадией АС.

Актуальность исследования обусловлена необходимостью мониторинга и прогнозирования изменений, происходящих в нефтезагрязненном грунте, в частности, интенсивности процесса биотрансформации нефти и нефтепродуктов, а также изменения количества органотрофных микроорганизмов во времени. Данные, полученные в результате моделирования процессов в системе почва–нефть–микроорганизмы позволят повысить эффективность очистки нефтезагрязненного грунта и тем самым оздоровить окружающую природную среду. Целью исследования являлось создание математической модели, воспроизводящей процесс деструкции компонентов тяжелой нефти ассоциацией аборигенных нефтедеструктирующих микроорганизмов. Объектом исследования выступал грунт, загрязненный тяжелой нефтью Нижне-Кармальского месторождения (Республика Татарстан), а также ассоциация аборигенных нефтедеструктирующих микроорганизмов. Методы. В качестве базы для моделирования была рассмотрена модифицированная модель Келлера–Сигала, которая учитывала также процессы диффузии нефтепродуктов и хемотаксис микроорганизмов. Система уравнений решалась численно, для чего была написана программа на языке Python. Численное решение осуществлялось методом предиктор–корректор. Результаты. Проведенная работа состояла из двух этапов – экспериментального и расчетного. В ходе первого этапа работы было произведено исследование процесса биодеструкции нефти и нефтепродуктов консорциумом аборигенных нефтедеструктирующих микроорганизмов. На основании полученных результатов была сформирована база экспериментальных данных. На втором этапе по ранее полученным данным было осуществлено построение математической модели, описывающей процесс биодеградации тяжелой нефти и изменение численности нефтедеструктирующих микрорганизмов в нефтезагрязненном грунте. Проведенные вычисления показали достаточно высокую согласованность расчетных данных c экспериментальными. Полученная модель позволит уже на ранних этапах очистки спрогнозировать мероприятия по экологически безопасным способам очистки нефтезагрязненных грунтов. The relevance of the research is caused by the need to monitor and predict changes in oil-contaminated soil, in particular, to intensify biodegradation of oil and oil products, as well as changes in the number of organotrophic microorganisms over time. The data, obtained from modeling in the system «soil-oil-microorganisms», will increase the efficiency of cleansing oil-contaminated soil and thereby improve the environment. The aim of the research was to create a mathematical model reproducing heavy oil components degradation by association of indige-nous petrodestructive microorganisms. The object of the study is the heavy oil-contaminated soil of the Nizhne-Karmalskoe field, as well as the association of indigenous petrodestructive microorganisms. Methods. The modified Keller-Segal model, which also takes into account the processes of diffusion of petroleum products and the hemotaxis of microorganisms, was used as a database for modeling. The system of equations was solved numerically, using a specially developed in the Python language program. The numerical solution was carried out using the predictor-corrector method. Results. The work consisted of two stages - experiment and calculation. During the first stage of the work, the biodegradation of oil and petroleum products was studied by a consortium of indigenous oil destructive microorganisms. On the basis of the obtained results, the experimental data base was established. At the second stage, according to the previously obtained data, the authors constructed a mathematical model describing heavy oil biodegradation and changes in the number of oil-destructing microorganisms in oil-contaminated soil. The calculations showed great consistency of estimated data with experimental ones. The obtained model would predict measures for environmental friendly methods of cleaning oil-contaminated soils at the early stages of cleaning.

The present article is based on Western, Japanese and field-work materials of the author who describes the main stages of formation of the Indian entrepreneurial diaspora in Japan in the period from the late 19th century until the beginning of the World War II. Indian entrepreneurs, being the representatives of trade and usury communities, Sindhis and Parsis in particular, started to arrive here in 1870s under British protection. Their main occupation was the export of Japanese textile which was the main export item of Japan in the mentioned period. Indians maintained the export of the textile goods, silk and cotton, in different countries all over the world through their strong entrepreneurial networks. The majority of Indian firms in Japan were Sindhis firms, and Sindhis network was especially prominent. Indian firms especially prospered in 1920-1930s, when their share of Japanese textile export constituted about 70 %. Thanks to strong ethnic loyalties, Indians in Japan could not only prosper but also successfully adapt to closed Japanese society. The article considers the pattern of settlement of Indians in Japan, and emphasizes two stages of Indian community formation in the pre-War period. The first one lasted from 1870s till 1923 year, when the community was formed basically in Yokohama. And the second stage after Great Kanto Earthquake lasted from 1923 till 1939, when it was constituted mainly in Kobe, which in present days remains the centre of Indian entrepreneurial community in Japan.

To synthesize Maxwell optics systems, the mathematical apparatus of tensor and vector analysis is generally employed. This mathematical apparatus implies executing a great number of simple stereotyped operations, which are adequately supported by computer algebra systems. In this paper, we distinguish between two stages of working with a mathematical model: model development and model usage. Each of these stages implies its own computer algebra system. As a model problem, we consider the problem of geometrization of Maxwell's equations. Two computer algebra systems---Cadabra and FORM---are selected for use at different stages of investigation., in Russian; in English

Suggested and substantiated is the integrated algorithm for diagnostics of dangerous infectious diseases that require measures on sanitary protection of territories using clinical, epidemiological and laboratory diagnostic standards. These standards are based on criteria for detection of suspected, probable and confirmed cases, with consideration for clinical manifestations, epidemiological anamnesis and laboratory analysis results. Distinguished and described are two stages for diagnosis of new infectious diseases that represent an emergency in the sphere of sanitary and epidemiological well-being of the population.

Conditions of formation of basalts of the Volyn-Podolian plate (VPP) have been considered. In Vendian primary melts which were close by their composition to picritic gabbro were differentiated at the depth of 30-35 km during first two stages of activization. The third stage when tuffs of the percalian terrain could be produced is not unambiguously subdivided. If the suggested scheme of the process is realized the result of activization in Vendian will be the cold mantle and basic mantle because the melts produced by the upper (crust) asthenosphere are basalts. For explanation of anomalies of paleotemperatures, special features of composition of hydrothermal solutions it is necessary to assume the existence of one more stage (separate activisation) in the territory of VPP.

Objective: to study the mechanisms responsible for the deposition of fluid and toxins in severe surgical endotoxicosis. Materials and methods. The reasons for triggering the mechanisms of deposition of fluid and toxins were clarified in an experimental study on animals (10 dogs) that were divided into 2 groups. All the animals were daily monitored for blood and central lymph toxicities, total circulating blood volumes, and body weight changes during natural (Group 1) and accelerated (Group 2) lymphokinesis. Whether the interstitium could be unloaded from deposited fluid and toxins was investigated in 56 patients with severe endotoxicosis. Results. In severe surgical endotoxicoses, fluid and toxins are deposited in the first days of the disease. The main reason for triggering the mechanism of deposition is the level of toxemia. The depositing process proceeds in two stages. Thoracic duct cannulation with external lymph drainage is the most effective way of unloading the interstitium from fluid and toxins. Key words: endotoxicosis, toxin deposition, interstitial space.