1. Place of the cardiosplenic axis in the development of fatal myocardial infarction
- Author
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M. A. Kercheva, V. V. Ryabov, A. Е. Gombozhapova, A. A. Trusov, I. V. Stepanov, and Yu. G. Kzhyshkowska
- Subjects
myocardial infarction ,inflammation ,cardiosplenic axis ,macrophages ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Aim. To compare data on the features of spleen macrophage composition in patients with fatal myocardial infarction (MI) and in patients from the control group without cardiovascular disease (CVD).Material and methods. The study included patients with fatal MI (n=30) and control group (n=5) — persons without CVD who died from injuries not compatible with life. Macrophage infiltration of spleen and myocardium fragments taken during autopsy was assessed by immunohistochemistry using macrophage markers CD68, CD163, CD206, stabilin-1.Results. There were following number of cells studied by us in the red pulp (RP) in patients with MI: CD163+, 906 (661; 1101), CD68+, 898 (807; 1049), stabilin-1+, 811 (531; 966), CD206+, 11 (9; 19); control group: CD163+, 400 (315; 513), CD68+, 40 (37; 45), stabilin-1+, 186 (107; 206), CD206+, 80 (70; 84). The content of all cells in the RP in patients with MI was high and prevailed over their number in the control group, while only the CD206+ concentration was inferior in number; in the control group, CD163+ cells predominated (p
- Published
- 2023
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