Search

Forecasts indicate that in the next decade cancer will become the most common cause of death in our country. Over 140,000 new cases of malignant neoplasms are reported annually in Poland. Colorectal cancer (CRC) is one of the most frequently detected malignancies: third in men and second in women. The aim of the study was the assessment of colonoscopy screening for early detection of colorectal cancer by elderly screening subjects. The study group consisted of 106 elderly people (aged 66 years and older), and the control group consisted of 100 consecutive people aged 40 to 65 years who reported to the Clinic for colonoscopy screening under PBP. Subjects from the control group expressed much more positive opinion about the usefulness of colonoscopy screening. 99,1% of subjects from this group assessed the examination as “very useful”, while in the study group such an opinion was expressed by 76% of subjects (p

Aims. A prophylaxis program for the early detection of colorectal cancer carried out by our department since the year 2000 has been extended to include people aged 65 and older. The subjects were asked additional questions regarding their dietary habits and possible coexistence of type 2 diabetes, and women were asked about the use of hormone replacement therapy. A physical examination, including measurements of nutritional status, was conducted. The aim of the study was to assess the effect of overweight, obesity, type 2 diabetes and hormone replacement therapy on the incidence of cancers and adenomas detected by colonoscopy screening in people aged 65 and older. Methods. The study method was standard colonoscopy screening conducted in people aged 65 and older, in whom no clinical signs suggesting the presence of colorectal cancer were observed. The subjects examined provided their answers to a number of questions related to coexisting conditions and medicines taken, and women were asked about their use of hormone replacement therapy in the past. Every subject underwent a thorough physical examination that included basic anthropometric measurements. Results. Subjects with obesity, type 2 diabetes, and women who had used hormone replacement therapy had a greater risk of developing colorectal cancer. Conclusions. The increased risk of colorectal cancer in people with obesity and type 2 diabetes, as well as women undergoing hormone replacement therapy, may be associated with insulin-like growth factor 1 (IGF-1). This polypeptide shows a similarity to insulin, is an active compound in the process of carcinogenesis and plays a role in the regulation of cell growth, proliferation, differentiation and apoptosis. Elucidating the molecular mechanism of action of IGF-1 is important for identifying the causes of tumorigenesis and can also be of significance for the future development of effective methods of treating malignancies.

Introduction. Colonoscopy screening for the early detection of colorectal cancer (CRC), despite many limitations, is widely used in the prevention of this most common digestive tract malignancy due to some important advantages. CRC is a nutrition-dependent disease. It is estimated that implementing rational nutrition as part of health promotion activities during childhood and continuing it in the adult life could reduce the morbidity and mortality of colon and rectal cancer. The aim of the study was to assess the effect of dietary habits on the incidence of colorectal adenomas and cancers in the population aged 65+ subjected to colonoscopy screening. Methods. The study method was standard colonoscopy screening conducted in subjects aged 65+ in whom no clinical signs of CRC were observed. The subjects were also assessed for their nutrition and the frequency of consumption of selected products, including red meat, vegetables, fruit and fried foods, using a standardized questionnaire prepared in cooperation with the Department of Nutrition and Dietetics, Collegium Medicum in Bydgoszcz, Poland. Results. Most CRC detections and the greatest number of excised adenomas were reported in subjects consuming vegetables as rarely as several times per year. Conclusions. Consumption of vegetables, among other foods, as part of rational nutrition from childhood through adult life may reduce the morbidity and mortality due to CRC.

Forecasts indicate that in the next decade cancer will become the most common cause of death in our country. Over 140,000 new cases of malignant neoplasms are reported annually in Poland. Colorectal cancer (CRC) is one of the most frequently detected malignancies: third in men and second in women. The aim of the study was the assessment of colonoscopy screening for early detection of colorectal cancer by elderly screening subjects. The study group consisted of 106 elderly people (aged 66 years and older), and the control group consisted of 100 consecutive people aged 40 to 65 years who reported to the Clinic for colonoscopy screening under PBP. Subjects from the control group expressed much more positive opinion about the usefulness of colonoscopy screening. 99,1% of subjects from this group assessed the examination as “very useful”, while in the study group such an opinion was expressed by 76% of subjects (p

Aims. A prophylaxis program for the early detection of colorectal cancer carried out by our department since the year 2000 has been extended to include people aged 65 and older. The subjects were asked additional questions regarding their dietary habits and possible coexistence of type 2 diabetes, and women were asked about the use of hormone replacement therapy. A physical examination, including measurements of nutritional status, was conducted. The aim of the study was to assess the effect of overweight, obesity, type 2 diabetes and hormone replacement therapy on the incidence of cancers and adenomas detected by colonoscopy screening in people aged 65 and older. Methods. The study method was standard colonoscopy screening conducted in people aged 65 and older, in whom no clinical signs suggesting the presence of colorectal cancer were observed. The subjects examined provided their answers to a number of questions related to coexisting conditions and medicines taken, and women were asked about their use of hormone replacement therapy in the past. Every subject underwent a thorough physical examination that included basic anthropometric measurements. Results. Subjects with obesity, type 2 diabetes, and women who had used hormone replacement therapy had a greater risk of developing colorectal cancer. Conclusions. The increased risk of colorectal cancer in people with obesity and type 2 diabetes, as well as women undergoing hormone replacement therapy, may be associated with insulin-like growth factor 1 (IGF-1). This polypeptide shows a similarity to insulin, is an active compound in the process of carcinogenesis and plays a role in the regulation of cell growth, proliferation, differentiation and apoptosis. Elucidating the molecular mechanism of action of IGF-1 is important for identifying the causes of tumorigenesis and can also be of significance for the future development of effective methods of treating malignancies.

Introduction. Colonoscopy screening for the early detection of colorectal cancer (CRC), despite many limitations, is widely used in the prevention of this most common digestive tract malignancy due to some important advantages. CRC is a nutrition-dependent disease. It is estimated that implementing rational nutrition as part of health promotion activities during childhood and continuing it in the adult life could reduce the morbidity and mortality of colon and rectal cancer. The aim of the study was to assess the effect of dietary habits on the incidence of colorectal adenomas and cancers in the population aged 65+ subjected to colonoscopy screening. Methods. The study method was standard colonoscopy screening conducted in subjects aged 65+ in whom no clinical signs of CRC were observed. The subjects were also assessed for their nutrition and the frequency of consumption of selected products, including red meat, vegetables, fruit and fried foods, using a standardized questionnaire prepared in cooperation with the Department of Nutrition and Dietetics, Collegium Medicum in Bydgoszcz, Poland. Results. Most CRC detections and the greatest number of excised adenomas were reported in subjects consuming vegetables as rarely as several times per year. Conclusions. Consumption of vegetables, among other foods, as part of rational nutrition from childhood through adult life may reduce the morbidity and mortality due to CRC.