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Background. One of the important conditions for the final victory over tuberculosis is not only the prevention of its development and early detection, but also the provision of high-quality personalized medical care to the patient. Additive technologies and virtualization technologies are ways to fully reveal this principle in phthisiatric practice. Aim. Demonstrate the possibilities and evaluate the labor costs (time spent on virtualization and the size of the final digital files of models) while working with the Mimics inPrint 2.0.0.159 and Mimics Medical 21.0.0.406 software systems in the aspect of virtual reconstruction of the lungs of a patient with a destructive form of tuberculosis. Materials and methods. A comparative analysis of methods for creating virtual three-dimensional models of the lungs from CT images was carried out at the Nizhny Novgorod Regional Clinical Tuberculosis Dispensary. The study involved one patient with a destructive form of tuberculosis of the upper lobe of the left lung. Virtual three-dimensional models were made according to a specially developed algorithm. The time spent for the formation of virtual lung models was analyzed using the built-in function in the "Log" software. The analysis of the size of the obtained virtual lung models in the STL format was carried out using the operating system function from the Windows family "Properties", section "General", subsection "Size". Results. The most practical software package for virtual lung reconstructions turned out to be Mimics inPrint 2.0.0.159 with the result of the time spent on creating a model of 2 minutes (Mimics Medical 21.0.0.406 7 minutes 17 seconds) and a model size of 125 megabytes (Mimics Medical 21.0.0.406 26.1 megabyte). The technical nuances and algorithms of lung reconstruction covered in the article using the Mimics inPrint 2.0.0.159 and Mimics Medical 21.0.0.406 software packages will allow the interested person not to make a mistake in realizing their scientific and practical interests in the process of providing personalized care to the patient. The article focuses on the main advantages of the Mimics inPrint 2.0.0.159 software package in comparison with Mimics Medical 21.0.0.406. A brief description of similar programs is given. Conclusion. The studied software systems successfully coped with the goal assigned to them, which concerned the demonstration of their capabilities and the assessment of labor costs for virtualization. Mimics inPrint 2.0.0.159 turned out to be the most understandable and promising software and application complex for use in everyday clinical practice.

Stroke is one of the leading causes of death and disability worldwide. The consequences of a stroke are manifested by deep and persistent clinical symptoms, which largely impose a burden on both the patient and society. Current treatments for ischemic stroke have proven to be inadequate, in part because of an incomplete understanding of the cellular and molecular changes that occur during a stroke. Microribonucleic acids (MicroRNAs) are endogenously expressed ribonucleic acid (RNA) of 18-22 nucleotides in length that suppress gene expression at the post-transcriptional level by binding to the 3'-untranslated region of the messenger ribonucleic acids targets. MicroRNAs are involved in virtually all biological processes, including cell proliferation, apoptosis, and cell differentiation, but also play a key role in the pathophysiological processes that contribute to ischemic damage. Moreover, miRNAs can represent not only potential biomarkers, but also become new therapeutic targets in clinical practice, which again confirms the need for their study. Therapy based on miRNA, includes agonists or facial expressions and inhibitors (antagomirs), which accordingly reduces and increases the expression of target genes. In this review, we summarize the current knowledge of fundamental research in the use of microRNAs in the treatment of stroke. The treatment methods, time windows and dosages for the effective delivery of microRNA-based drugs to the central nervous system are discussed. The effects of microRNA therapy on the main pathological mechanisms of stroke, including oxidative stress, inflammation, apoptosis, angiogenesis, neurogenesis, and the safety of the blood-brain barrier are considered.

The purpose of the research is to reveal the features of the use of a human behaviour manner in the process of preparing a cinema actor preparing for a role. The research methodology is based on the principles of descriptive, comparative, cultural and artistic methods, the method of observation and experiment, in addition, individualizing and social and psychological approaches are applied during the study of the psycho-physiology of acting through the analysis of the behaviour in the process of individual human capabilities disclosing. The scientific novelty of the research is that the workmanship of the acting game is analyzed through the allocation of a visual demonstration of the manner of behaviour from the inner senses of the character for the first time. Conclusions. The research has shown and analyzed the use of human behaviour in the process of film actor preparing for his/her role. It has been found that the accumulated experience of body movements enriches the repertoire of acting, reduces the risk of the hero emotional state over the inner freedom of a professional actor. Accordingly, with the explored information, the main point here is that impersonation for a character is demonstrating by the simplest properties of human behaviour.

Research issues related to indirect communication engaged paralinguistics studying the factors that accompany speech communication and engaged in the transfer of information. The funds, which are called paralinguistic can give meaning to a variety of shades of expression, including direct antonymous sense, transmitted verbally.

Modern methods of diagnosing of maxillary bones in various clinical situations presume a method of computer tomography. In some cases, the treatment planning according to three-dimensional image cannot be performed and the question of creation of the biomechanical model study area arises. Various methods of computer-aided design and three-dimensional modeling are worth while using to achieve the realization of the task.