1. Investigation of premalignant senescence in human dermal fibroblasts
- Subjects
sirt6 ,epigenetics ,hp1 ,беÑа-галакÑозидаза ,ÑпигенеÑика ,beta-galactosidase ,канÑеÑогенез ,brca1 ,cancerogenesis ,биомаÑкеÑÑ ÑÑаÑÐµÐ½Ð¸Ñ ,atm ,клеÑоÑное ÑÑаÑение ,cellular senescence ,наÑледÑÑвеннÑе опÑÑ Ð¾Ð»ÐµÐ²Ñе ÑиндÑÐ¾Ð¼Ñ ,ÑдеÑÐ½Ð°Ñ Ð»Ð°Ð¼Ð¸Ð½Ð° ,biomarkers of ageing ,nuclear lamina ,hereditary cancer syndromes - Abstract
Рданной ÑабоÑе ÑаÑÑмаÑÑиваеÑÑÑ Ñеномен клеÑоÑного ÑÑаÑÐµÐ½Ð¸Ñ Ð² конÑекÑÑе наÑледÑÑвеннÑÑ Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²ÑÑ ÑиндÑомов. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ñ Ð½ÐµÐºÐ¾ÑоÑÑе маÑкеÑÑ ÐºÐ»ÐµÑоÑного ÑÑаÑÐµÐ½Ð¸Ñ Ð² деÑмалÑнÑÑ ÑибÑоблаÑÑÐ°Ñ Ñеловека, полÑÑеннÑÑ Ð¾Ñ Ð¿Ð°ÑиенÑов Ñ Ð¼ÑÑаÑией 5382insC в гене BRCA1 и Ñ Ð½Ð°ÑÑÑенной ÑÑнкÑионалÑной акÑивноÑÑÑÑ ÐºÐ¸Ð½Ð°Ð·Ñ ÐТÐ., In the given work the cellular senescence phenomenon is reviewed from the point of view of hereditary cancer syndromes. Some senescence-related markers in human dermal fibroblasts obtained from donors with impaired functional activity of ATM kinase and 5382insC mutation in gene BRCA1 are observed.
- Published
- 2019
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