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The relevance of the study is determined by the strategic interests of the Russian Federation dictating the need to achieve a national priority, which is the development of human potential. Given the ongoing reduction in labor force against a background of depopulation processes, finding a solution to the problem seems especially relevant. The purpose of this study is to develop a scientific conceptual framework for an intelligent risk-based innovative system for analysis, prediction and prevention of occupational and work-related health disorders of workers. This will help substantiate keynote sanitary-hygienic and medical-preventive measures aimed at reducing losses in healthy life expectancy and increasing occupational longevity. The main theoretical idea is based on a unique information-intellectual innovative system for analyzing and predicting cause-and-effect relationships between the effects of harmful and hazardous occupational factors and the resulting health problems of workers, occupational diseases included. The developed predictive digital neural network models, trained on retrospective or actual data on working conditions, health status, socioeconomic conditions and lifestyle factors, are the information and analytical basis for carrying out calculations and assessing the evolution of personal and group (occupation, age, and work records) health risks caused by occupational or work-related diseases in workers. This provides solid grounds for making a forecast of a prevented period of reduction in occupational working capacity associated with working conditions, specifically for each examined occupation, age, and work records. Such forecasts are an eligible information basis for developing and making well-grounded managerial decisions including those concerning sanitary, hygienic and medical preventive measures aimed at preserving occupational longevity. This will significantly increase effectiveness of corporate health-preserving policies.

Objectives. To analyze the morbidity with temporary disability (MTD) of the employees of the workshop for tableting and packaging medicines and to assess their occupational risk. Material and methods. Based on the data of temporary disability certificates, a detailed analysis of the MTD of employees of the workshop for tableting and packaging medicines (main group, n=640 year-round person-years) was carried out in comparison with the morbidity of employees of management departments (comparison group, n=1458 year-round person-years). The calculation of the indicator of the actual level of occupational risk was made on the basis of the total coefficient of working conditions, the indicator of relative risk, the indicator of non-compliance with sanitary and hygienic requirements according to the checklist of questions and the indicator of occupational morbidity. Results. The overall morbidity rate by cases and by days per 100 workers employed during tableting and packaging medicines was assessed as “below average” for the analyzed period. However, at the same time, the comparison with the republican average annual morbidity rates with temporary disability reflected statistically significantly higher levels of morbidity in cases of temporary disability and the integral indicator among production shop workers. Most often, the causes of incapacity for work of shop workers were diseases of the respiratory system, musculoskeletal system, neoplasms, injuries and poisoning, as well as diseases of the circulatory system. The indicator of the actual level of occupational risk in the workshop made up 2.6, which testifies to a high degree of occupational conditionality of health disorders among workers. Conclusions. Investigations, the main purpose of which is to study the factors of the working environment, the nature of work, and their contribution to the development of both occupational, professionally caused, and somatic diseases, are the basis for developing a preventive strategy to minimize the occupational risk to the health of pharmaceutical enterprises workers.

An increase in retirement age means that employment period is prolonged; it calls for preserving people’s working capacities for a longer period of time including those with long-term working experience. It is especially vital when it comes to adverse working conditions that might cause high health risks for workers due to work-related diseases. We suggested methodical approaches to determining individual occupational health risks; these approaches took into account occupationally induced negative responses to impacts exerted by work-related factors; pathogenetic mechanisms of health disorders occurrence; gravity of health disorders; workers’ age and working experience. To implement these approaches, we applied a set of procedures that included hygienic and epidemiologic analysis, clinical and laboratory examination of workers, mathematic modeling and prediction. We tested these approaches via assessing occupational health risks for workers employed at oil-extracting enterprises and it allowed us to determine parameters of dependence between changes in arterial hypertension predictors under exposure to occupational noise and changes in age and working experience (b0=0.1427; b1=0.007; b2=-0.372). The obtained parameters can be used in assessing risks of arterial hypertension occurrence due to exposure to occupational noise for workers employed in oil extraction. Individual occupational risk caused by arterial hypertension in people exposed to occupational noise was higher than its permissible level (1∙10-3) for 13% workers (33 people) aged from 41 to 52 and working experience from 19.8 to 33 years; the risk detected in our research amounted up to 2.4∙10-2. Maximum individual risks of work-related arterial hypertension that are predicted to occur at an age close to 59 years amount up to 4.3∙10-2 and they will be higher than permissible levels for 56.6% работников; at an age close to 65 years, up to 4.7∙10-2, and they will be higher than permissible levels for 64.8% workers.