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Značaj multidimenzionalnog uticaja maksilofacijalnih tumora je doveo do povećanog interesovanja za kvalitet života pacijenata. Studije QOL(Quality of Life) daju kliničke informacije o efektima bolesti, terapiji i neželjenim efektima. Prednosti za pacijenta u ovim studijama su te da mogu da izraze svoje mišljenje o negativnim aspektima bolesti i doprinesu u donošenju terapijskih odluka jer vreme preživljavanja nije direktno povezano sa poboljšanjem „kvaliteta života“. Cilj ovog istraživanja bio je da se ispita efekat različitih terapijskih modaliteta na radijacioni mukozitis u pacijenata sa postresekcionim defektima orofacijalne regije. Metodologija: U ovom istraživanju, je uključeno 30 pacijenata sa tumorima orofacijalne regije koji su posle hirurške terapije protetski rehabilitovani i podvrgnuti zračnoj terapiji.Pacijenti su podeljeni u tri grupe po deset ispitanika. Metodom slučajnog izbora, jednoj grupi ispitanika je dat standarni protokol u terapiji radijacionih mukozitisa, koja će predstavljati kontrolnu grupu. Drugoj i trećoj grupi ispitanika su pored standardne terapije uključeni preparati „Stomatovis“ i „Gelclair“ i predstavljaju eksperimentane grupe. BMS upitnici (0. i kontrolni ) su korišćeni u vizuelnoj kvalifikaciji simptomatologije pacijenta. Procena podataka kvaliteta života je obrađena u upitniku EORTC-QLQ-C30 verzija 3.0 i njegovom dodatku H&N35, na srpskom jeziku. Upitnik OHIP-20 (The Oral Health Impact Profile) je korišćen u proceni kvaliteta protetske terapije pacijenata. Mikrobiološka obrada uzoraka materijala, kao i identifikacija izolovanih vrsta mikroorganizama, vršeni su u laboratoriji predmeta Mikrobiologija i imunologija stomatološkog fakulteta u Beogradu. Postupak je podrazumevao standardnu mikroskopsku, kulturalnu i biohemijsku identifikaciju. Identifikacija je predstavljala standardne bakteriološke metode, a kvantifikacija je obavljana brojanjem izniklih kolonija na zasejanim hranljivim podlogama. Pri tome su rezultati izraženi kao ukupan broj CFU (Colony Forming Unit) izniklih kolonija po uzorku materijala. Rezultati: Simptomatologija pacijenata se kroz faze ispitivanja pogoršavala. Visoke vrednosti kserostomije, poremećaja ukusa i bola, a veoma niske vrednosti salivarnog protoka BMS -kontrolnog upitnika ukazuju na sporedni štetni efekat zračne terapije. Za razliku od kontrolne i stomatovis grupe, kod gelclair grupe ispitanika intenzitet simptoma se postepeno povećavao kroz sve tri faze istraživanja. Ispitanici gelclair grupe su imali znatno manje tegoba u gutanju hrane tokom svih faza zračne terapije i značajno manje bolova, tokom 2. i 3. faze zračenja. Imali su manje problema u uzimanju obroka pred drugim ljudima, manje bolnih senzacija i manje bolnih mesta u ustima, bili manje uznemireni zbog problema sa protezama, tolerantniji prema ukućanima i imali manji subjektivni osećaj stanja bolesti u odnosu na kontrolnu i stomatovis grupu. Najizraženija kolonizacija bakterije je nađena u brisevima uzetih sa površine obturator ploče koja je okrenuta prema oralnoj sluzokoži, oralne sluzokože u okolini defekta i obturator ploče koja je okrenuta prema defektu u 2.fazi ispitivanja i to Stafilokoka, Streptokoka i Candida-e, dok se broj kolonija Gram negativnih bakterija nađenih u brisevima uzetih sa različitih ispitivanih površina, u sve 3 faze zračne terapije, nije značajno razlikovao kod ispitivanih grupa... Introduction: The significance of multi-dimensional influence of maxillofacial tumors brought about an increased interest in patients "Quality of Life". The studies of Quality of Life give clinical information about the disease effects, therapy and undesired effects. The advantages for the patients in these studies are such that they can express their opinion on the negative aspects of the disease and contribute in making therapeutic decisions since the period of outliving is not directly connected with the improvement of QOL. The aim of this study was to research the effects of various therapeutic modalities on radiation mucositis in patients with postresectional defects of orofacial region. Methodology: This study includes 30 patients with orofacial region cancer who were consecutively prosthetically rehabilitated after the surgical threatment and subjected to radiotherapy. The patients were divided into three groups of respondents. By random selection method, one group of respondents had a standard protocol in radiation mucositis therapy representing control group. The second and the third group had preparations Stomatovis and Gelclair along with standard therapy representing experimental groups. BMS questionnaires (0., and control) were used in visual qualification of the patients symptomatology. Evaluation of quality of life data was done by the questionnaire EORTC QLQ C-30 in version 3.0 and its addition QLQ H&N35, in the Serbian language. The questionnaire OHIP20 (The Oral Health Impact Profile) was used in evaluation the Quality of the prosthetic therapy in patients. Both microbiological work of material patterns and identification of isolated kinds of microorganisms were done in the laboratory - department Microbiology and Immunology of the Dentistry School in Belgrade. The treatment meant standard microscopic, cultural and biochemical identification. The identification meant standard bacteriological methods and quantification was done counting sprouted colonies on the sown nourishing bases. The results are expressed as the total number CFU (Colony Forming Unit) of the sprouted colonies per material pattern. Results: Patients symptomatology got worse through the testing phases. High values of xerostomia, taste disorder, pain and too low values of salivary flow in the BMS control questionnaire show the secondary harmful effect of the radiation. The intensity of symptoms gradually increased through all three phases of research in Gelclair group of respondents compared with Control and Stomatovis groups. Gelclair group respondents had mainly less trouble in swallowing food during all the phases of radiation and considerably less pain during the second and third phase of radiation. They had less trouble in social eating, less painful sensations and less painful spots in their mouths. They were less nervous having the problem with prostheses, were more tolerant with their inmates and they felt less ill compared with the Stomatovis and Control groups. The most distinct colonization of bacteria was found in the swabs taken from the surfaces of the obturator plate which is turned toward the oral mucous membrane; in the swabs of oral mucous membrane around the defect and obturator plate which is turned toward the defect in the second phase of testing and it was Staphylococcus, Streptococcus and Candida. While the number of colonies of gram negative bacteria found in the swabs taken from various tested surfaces in all the phases of radiation didn't considerably differ in the tested groups...

Introduction: The significance of multi-dimensional influence of maxillofacial tumors brought about an increased interest in patients "Quality of Life". The studies of Quality of Life give clinical information about the disease effects, therapy and undesired effects. The advantages for the patients in these studies are such that they can express their opinion on the negative aspects of the disease and contribute in making therapeutic decisions since the period of outliving is not directly connected with the improvement of QOL. The aim of this study was to research the effects of various therapeutic modalities on radiation mucositis in patients with postresectional defects of orofacial region. Methodology: This study includes 30 patients with orofacial region cancer who were consecutively prosthetically rehabilitated after the surgical threatment and subjected to radiotherapy. The patients were divided into three groups of respondents. By random selection method, one group of respondents had a standard protocol in radiation mucositis therapy representing control group. The second and the third group had preparations Stomatovis and Gelclair along with standard therapy representing experimental groups. BMS questionnaires (0., and control) were used in visual qualification of the patients symptomatology. Evaluation of quality of life data was done by the questionnaire EORTC QLQ C-30 in version 3.0 and its addition QLQ H&N35, in the Serbian language. The questionnaire OHIP20 (The Oral Health Impact Profile) was used in evaluation the Quality of the prosthetic therapy in patients. Both microbiological work of material patterns and identification of isolated kinds of microorganisms were done in the laboratory - department Microbiology and Immunology of the Dentistry School in Belgrade. The treatment meant standard microscopic, cultural and biochemical identification. The identification meant standard bacteriological methods and quantification was done counting sprouted colonies on the sown nourishing bases. The results are expressed as the total number CFU (Colony Forming Unit) of the sprouted colonies per material pattern. Results: Patients symptomatology got worse through the testing phases. High values of xerostomia, taste disorder, pain and too low values of salivary flow in the BMS control questionnaire show the secondary harmful effect of the radiation. The intensity of symptoms gradually increased through all three phases of research in Gelclair group of respondents compared with Control and Stomatovis groups. Gelclair group respondents had mainly less trouble in swallowing food during all the phases of radiation and considerably less pain during the second and third phase of radiation. They had less trouble in social eating, less painful sensations and less painful spots in their mouths. They were less nervous having the problem with prostheses, were more tolerant with their inmates and they felt less ill compared with the Stomatovis and Control groups. The most distinct colonization of bacteria was found in the swabs taken from the surfaces of the obturator plate which is turned toward the oral mucous membrane; in the swabs of oral mucous membrane around the defect and obturator plate which is turned toward the defect in the second phase of testing and it was Staphylococcus, Streptococcus and Candida. While the number of colonies of gram negative bacteria found in the swabs taken from various tested surfaces in all the phases of radiation didn't considerably differ in the tested groups..., Značaj multidimenzionalnog uticaja maksilofacijalnih tumora je doveo do povećanog interesovanja za kvalitet života pacijenata. Studije QOL(Quality of Life) daju kliničke informacije o efektima bolesti, terapiji i neželjenim efektima. Prednosti za pacijenta u ovim studijama su te da mogu da izraze svoje mišljenje o negativnim aspektima bolesti i doprinesu u donošenju terapijskih odluka jer vreme preživljavanja nije direktno povezano sa poboljšanjem „kvaliteta života“. Cilj ovog istraživanja bio je da se ispita efekat različitih terapijskih modaliteta na radijacioni mukozitis u pacijenata sa postresekcionim defektima orofacijalne regije. Metodologija: U ovom istraživanju, je uključeno 30 pacijenata sa tumorima orofacijalne regije koji su posle hirurške terapije protetski rehabilitovani i podvrgnuti zračnoj terapiji.Pacijenti su podeljeni u tri grupe po deset ispitanika. Metodom slučajnog izbora, jednoj grupi ispitanika je dat standarni protokol u terapiji radijacionih mukozitisa, koja će predstavljati kontrolnu grupu. Drugoj i trećoj grupi ispitanika su pored standardne terapije uključeni preparati „Stomatovis“ i „Gelclair“ i predstavljaju eksperimentane grupe. BMS upitnici (0. i kontrolni ) su korišćeni u vizuelnoj kvalifikaciji simptomatologije pacijenta. Procena podataka kvaliteta života je obrađena u upitniku EORTC-QLQ-C30 verzija 3.0 i njegovom dodatku H&N35, na srpskom jeziku. Upitnik OHIP-20 (The Oral Health Impact Profile) je korišćen u proceni kvaliteta protetske terapije pacijenata. Mikrobiološka obrada uzoraka materijala, kao i identifikacija izolovanih vrsta mikroorganizama, vršeni su u laboratoriji predmeta Mikrobiologija i imunologija stomatološkog fakulteta u Beogradu. Postupak je podrazumevao standardnu mikroskopsku, kulturalnu i biohemijsku identifikaciju. Identifikacija je predstavljala standardne bakteriološke metode, a kvantifikacija je obavljana brojanjem izniklih kolonija na zasejanim hranljivim podlogama. Pri tome su rezultati izraženi kao ukupan broj CFU (Colony Forming Unit) izniklih kolonija po uzorku materijala. Rezultati: Simptomatologija pacijenata se kroz faze ispitivanja pogoršavala. Visoke vrednosti kserostomije, poremećaja ukusa i bola, a veoma niske vrednosti salivarnog protoka BMS -kontrolnog upitnika ukazuju na sporedni štetni efekat zračne terapije. Za razliku od kontrolne i stomatovis grupe, kod gelclair grupe ispitanika intenzitet simptoma se postepeno povećavao kroz sve tri faze istraživanja. Ispitanici gelclair grupe su imali znatno manje tegoba u gutanju hrane tokom svih faza zračne terapije i značajno manje bolova, tokom 2. i 3. faze zračenja. Imali su manje problema u uzimanju obroka pred drugim ljudima, manje bolnih senzacija i manje bolnih mesta u ustima, bili manje uznemireni zbog problema sa protezama, tolerantniji prema ukućanima i imali manji subjektivni osećaj stanja bolesti u odnosu na kontrolnu i stomatovis grupu. Najizraženija kolonizacija bakterije je nađena u brisevima uzetih sa površine obturator ploče koja je okrenuta prema oralnoj sluzokoži, oralne sluzokože u okolini defekta i obturator ploče koja je okrenuta prema defektu u 2.fazi ispitivanja i to Stafilokoka, Streptokoka i Candida-e, dok se broj kolonija Gram negativnih bakterija nađenih u brisevima uzetih sa različitih ispitivanih površina, u sve 3 faze zračne terapije, nije značajno razlikovao kod ispitivanih grupa...

Protezni stomatitis je često oboljenje kod pacijenata koji koriste totalne zubne proteze. Uglavnom protezni stomatitis nije praćen simptomima i pacijenti nisu svesni prisutnog oboljenja. Etiologija proteznog stomatitisa je multifaktorijalna. Kao dominantan faktor ističe se infekcija gljivama roda Candida. Totalne zubne proteze podležu kolonizaciji i formiranju biofilma Candida spp. Protezni plak (biofilm) je sličan dentalnom plaku i služi kao rezervoar potencijalno infektivnih mikroorganizama. Mikroorganizmi iz proteznog plaka, (najviše Candida spp.) su odgovorni za nastanak proteznog stomatitisa. Kontinuirano gutanje mikroorganizama iz proteznog plaka izlaže pacijente riziku od neočekivane infekcije. ajčešća izolovana vrsta gljive na protezama je C. albicans. Prisutni su opšti i lokalni kontributivni faktori. Lokalni faktori su: lezije oralne sluzokože uzrokovane neadekvatnim protezama, neprekidno nošenje zubne proteze, smanjen protok pljuvačke, loša higijena zubne proteze, vrsta materijala od koga je izrađena proteza, starost proteze, slaba retencija proteze, neizbalansirana okluzija. Opšti faktori su: diabetes mellitus, pušenje, dugotrajna primena antibiotika i kortikosteroida, radio i hemoterapija, faktori ishrane – nedostatak vitamina B12, folata i gvožđa, psihotropni lekovi, hiposalivatori. Cilj ovog istraživanja je bio da se pouzdano dijagnostikuje i odredi učestalost proteznog stomatitisa gljivične etiologije i ispita antifungalna aktivnost etarskih ulja. Za potrebe ovog istraživanja dizajniran je poseban upitnik, koji sadrži generalije, medicinsku i stomatološku istoriju i podatke dobijene kliničkim pregledom. Klinički pregled se sastojao od inspekcije usne duplje, na osnovu koga se dijagnostikovala inflamacija mekih tkiva, kao i stepen i lokacija inflamacije. Analizom postojećeg stanja totalne zubne proteze u ustima pacijenta utvrđivan je stepen retencije zubne proteze, očuvanost vertikalne dimenzije okluzije i okluzalni odnosi sa antagonistima. Deo istraživanja je sproveden u laboratoriji... Denture stomatitis is a common disease in patients with dentures. Generally, denture stomatitis is not followed by any symptoms and patients are usually not aware of the disease. Etiology of denture stotmatitis is multifactorial. As a dominant factor is the fungal infection by Candida spp. Complete dentures are susceptible to colonization and biofilm formation of Candida spp. Denture plaque (biofilm) is similar to a dental plaque and it is a reservoir of potential infective microorganisms. Microorganisms in denture plaque, (mostly Candida spp.) are responsible for the emergence of denture stomatitis. A continual swallowing of microorganism from denture plaque exposes patients to a risk of unexpected infection. The most common isolated species of fungus on dentures is C. albicans. There are some general and local contributory factors. The local factors are: trauma of oral mucosa caused by inadequate dentures, continuous dentures wearing, reduced saliva flow, bad dentures hygiene, type of the material dentures are made of, detures’age, poor dentures retention, unbalanced occlusion. The general factors are: diabetes mellitus, smoking, long antibiotics and corticosteroids application and radio or chemotherapy, diet factors, - lack of vitamin B12, foliates and iron, psychotropic medications and hyposalivators. The aim of this research has been to diagnose and designate a frequency of denture stomatitis of fungal etiology and examine antifungal activities of essential oils. For the needs of this research there has been designed a special questionnaire which contains .personal data, medical and stomatological history and data obtained by clinical examination. Clinical examination consisted of inspection of oral cavity on the basis of which a soft tissue inflammation has been diagnosed as well as a degree and location of the inflammation. Analysing the present state of complete dentures in patients’ mouth there has been established a degree of denture retention, preservation of vertical dimension of occlusion and occlusal relations with antagonists...

Denture stomatitis is a common disease in patients with dentures. Generally, denture stomatitis is not followed by any symptoms and patients are usually not aware of the disease. Etiology of denture stotmatitis is multifactorial. As a dominant factor is the fungal infection by Candida spp. Complete dentures are susceptible to colonization and biofilm formation of Candida spp. Denture plaque (biofilm) is similar to a dental plaque and it is a reservoir of potential infective microorganisms. Microorganisms in denture plaque, (mostly Candida spp.) are responsible for the emergence of denture stomatitis. A continual swallowing of microorganism from denture plaque exposes patients to a risk of unexpected infection. The most common isolated species of fungus on dentures is C. albicans. There are some general and local contributory factors. The local factors are: trauma of oral mucosa caused by inadequate dentures, continuous dentures wearing, reduced saliva flow, bad dentures hygiene, type of the material dentures are made of, detures’age, poor dentures retention, unbalanced occlusion. The general factors are: diabetes mellitus, smoking, long antibiotics and corticosteroids application and radio or chemotherapy, diet factors, - lack of vitamin B12, foliates and iron, psychotropic medications and hyposalivators. The aim of this research has been to diagnose and designate a frequency of denture stomatitis of fungal etiology and examine antifungal activities of essential oils. For the needs of this research there has been designed a special questionnaire which contains .personal data, medical and stomatological history and data obtained by clinical examination. Clinical examination consisted of inspection of oral cavity on the basis of which a soft tissue inflammation has been diagnosed as well as a degree and location of the inflammation. Analysing the present state of complete dentures in patients’ mouth there has been established a degree of denture retention, preservation of vertical dimension of occlusion and occlusal relations with antagonists..., Protezni stomatitis je često oboljenje kod pacijenata koji koriste totalne zubne proteze. Uglavnom protezni stomatitis nije praćen simptomima i pacijenti nisu svesni prisutnog oboljenja. Etiologija proteznog stomatitisa je multifaktorijalna. Kao dominantan faktor ističe se infekcija gljivama roda Candida. Totalne zubne proteze podležu kolonizaciji i formiranju biofilma Candida spp. Protezni plak (biofilm) je sličan dentalnom plaku i služi kao rezervoar potencijalno infektivnih mikroorganizama. Mikroorganizmi iz proteznog plaka, (najviše Candida spp.) su odgovorni za nastanak proteznog stomatitisa. Kontinuirano gutanje mikroorganizama iz proteznog plaka izlaže pacijente riziku od neočekivane infekcije. ajčešća izolovana vrsta gljive na protezama je C. albicans. Prisutni su opšti i lokalni kontributivni faktori. Lokalni faktori su: lezije oralne sluzokože uzrokovane neadekvatnim protezama, neprekidno nošenje zubne proteze, smanjen protok pljuvačke, loša higijena zubne proteze, vrsta materijala od koga je izrađena proteza, starost proteze, slaba retencija proteze, neizbalansirana okluzija. Opšti faktori su: diabetes mellitus, pušenje, dugotrajna primena antibiotika i kortikosteroida, radio i hemoterapija, faktori ishrane – nedostatak vitamina B12, folata i gvožđa, psihotropni lekovi, hiposalivatori. Cilj ovog istraživanja je bio da se pouzdano dijagnostikuje i odredi učestalost proteznog stomatitisa gljivične etiologije i ispita antifungalna aktivnost etarskih ulja. Za potrebe ovog istraživanja dizajniran je poseban upitnik, koji sadrži generalije, medicinsku i stomatološku istoriju i podatke dobijene kliničkim pregledom. Klinički pregled se sastojao od inspekcije usne duplje, na osnovu koga se dijagnostikovala inflamacija mekih tkiva, kao i stepen i lokacija inflamacije. Analizom postojećeg stanja totalne zubne proteze u ustima pacijenta utvrđivan je stepen retencije zubne proteze, očuvanost vertikalne dimenzije okluzije i okluzalni odnosi sa antagonistima. Deo istraživanja je sproveden u laboratoriji...