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Metildigoksin je zdravilna učinkovina, ki se že dalj časa uporablja za zdravljenje srčnega popuščanja in atrijske fibrilacije, vendar njegova zastopanost med zdravniki zaradi možnosti predpisovanja sodobnejših varnejših učinkovin v zadnjem času upada. Spada med učinkovine z ozkim terapevtskim območjem, v okviru katerih se režim odmerjanja načeloma nenehno prilagaja na osnovi koncentracije učinkovine v serumu. Zato je pomembno, da je za vsakega posameznega bolnika, pri katerem je potrebna terapija z metildigoksinom, optimalno terapevtsko območje dobro definirano in da se spremljanje serumskih koncentracij (metil)digoksina izvaja pravilno, saj je le tako moč zagotoviti ustrezno učinkovitost in varnost terapije z metildigoksinom. Pri optimiranju režima odmerjanja učinkovin z ozkim terapevtskim območjem naj bi zdravnikom in farmacevtom UKC Maribor bil v veliko pomoč, in v primeru gentamicina in vankomicina tudi je, farmakokinetični računalniški program Kinetidex®. Namen retrospektivne raziskave je bil ovrednotiti uporabnost Kinetidex®-a pri napovedovanju koncentracij (metil)digoksina v serumu. S prospektivno raziskavo pa smo v vsakdanjo klinično prakso želeli uvesti na osnovi pregleda aktualne literature pripravljena navodila za odmerjanje metildigoksina in spremljanje serumskih koncentracij (metil)digoksina. Nadalje je bil namen prospektivne raziskave v primeru za izbranega bolnika neustreznih nivojev (metil)digoksina v serumu določiti optimalni režim odmerjanja na osnovi izvedbe simulacije v Kinetidex®-u. V retrospektivno raziskavo smo izmed 206 bolnikov, ki so se med 1. januarjem in 31. marcem 2013 na Oddelku za kardiologijo in angiologijo UKC Maribor zdravili pod diagnozo atrijska fibrilacija in undulacija in/ali zastojna srčna odpoved, s pregledom popisa vsakega posameznega pacienta vključili 65 tistih, ki so se pred in med zdravljenjem v bolnišnici zdravili z metildigoksinom. V prospektivno raziskavo pa smo vključili 18 bolnikov, ki so se med 1. junijem in 31. julijem na Oddelku za kardiologijo in angiologijo UKC Maribor pred in med zdravljenjem v bolnišnici zdravili z metildigoksinom. Ugotovili smo, da je Kinetidex® pri napovedovanju koncentracij (metil)digoksina v serumu uporaben do te mere, da je na osnovi izvedene simulacije moč določiti za izbranega bolnika optimalni režim odmerjanja. Prav tako je simulacija zdravniku in farmacevtu lahko v pomoč pri odločitvi za odvzem serumskega vzorca, saj je iz grafa zelo jasno razvidno, kdaj se pri izbranem bolniku vzpostavi stacionarno stanje. Methyldigoxin is an active ingredient that has been used for a long time to treat heart failure and atrial fibrillation, but its prescription rate among physicians has dropped recently due to the possibility of prescribing modern and safer active ingredients. It belongs to the active ingredients with a narrow therapeutic window, requiring, in principle, a continual adjustment of their dosage regimen to the concentration of the active ingredient in the serum. It is therefore important that in patients requiring methyldigoxin therapy the therapeutic range is well defined and that the (methyl)digoxin concentration monitoring is correct to ensure adequate efficiency and safety of the therapy. Kinetidex®, a pharmacokinetic computer program, could be very helpful to the doctors and pharmacists at the University Medical Centre Maribor, as it is in gentamicin and vancomycin therapy, to optimise the dosage regimen of the active ingredients with a narrow therapeutic window. The purpose of retrospective study was to assess the applicability of Kinetidex® in forecasting (methyl)digoxin serum concentration levels. The purpose of prospective study on the other hand was to introduce the methyldigoxin dosage and serum (methyl)digoxin concentration monitoring instructions into everyday clinical practice following a review of the current literature. Furthermore, was the aim of prospective study to determine an optimal dosage regimen through a Kinetidex® simulation in patients with inadequate serum (methyl)digoxin levels. The retrospective study included 65 out of 206 patients treated for atrial fibrillation and undulation and/or congestive heart failure between 1 January and 31 March 2013 at the Department of Cardiology and Angiology of the University Medical Centre Maribor by reviewing a list of the patients receiving methyldigoxin therapy prior to and during the hospital treatment. And the prospective study included 18 patients receiving methyldigoxin therapy prior to and during the hospital treatment between 1 June and 31 July at the Department of Cardiology and Angiology of the University Medical Centre Maribor. The results of this study suggest that in forecasting serum (methyl)digoxin concentrations Kinetidex® is applicable to the extent that it is possible to define an optimal dosage regimen for a selected patient by carrying out a simulation. Likewise, a simulation may be helpful to doctors and a pharmacists in deciding to take a serum sample, since the graph clearly shows when the stationary state of a selected patient is reached.

Glavni cilj magistrskega dela je bil ugotoviti, ali vsakodnevna desetminutna vadba na delovnem mestu pozitivno vpliva na nekatere gibalne sposobnosti pri zaposlenih v lekarni. Zanimalo pa nas je tudi, ali pri zaposlenih v lekarni prihaja do bolečin v posameznih delih telesa. V raziskavo je bilo vključenih 24 preiskovancev. V vadbeno skupino smo vključili 16 preiskovancev, med katerimi je bilo več žensk (81,3 %). V kontrolno skupino smo vključili 8 preiskovancev v enakem deležu glede na spol. Vsi preizkušanci so zaposleni v lekarnah Javnega zdravstvenega zavoda Mariborske lekarne Maribor. Po urejenem dogovoru z zavodom in zaposlenimi ter po predstavitvi projekta smo na prvih meritvah pred vadbeno intervencijo izmerili rezultate izbranih gibalnih testov. Pri tem smo uporabili prirejeno obliko Nordijskega vprašalnika o mišično-skeletnih motnjah (Nordic Musculoskeletal Questionnaire) ter pridobili podatke o le-teh pri zaposlenih v lekarni (Franasiak, Craven, Mosaly in Gehrig, 2014). Po sedemtedenskem vadbenem obdobju smo ponovno izmerili rezultate testov gibalnih sposobnosti in pridobili podatke o mišično-skeletnih motnjah in pojavnosti bolečin v posameznem predelu telesa. Podatke smo statistično obdelovali v programu IBM SPSS 21 (SPSS Inc., Chicago, Illinois, ZDA) in slogovno urejali v programu Microsoft Excel 2016 (Microsoft Corporation, Seattle, Washington, ZDA). Številske podatke smo predstavili s povprečji in standardnimi napakami povprečij, številske ordinalne podatke smo predstavili z mediano in standardnimi napakami mediane, medtem ko smo opisne podatke predstavili v frekvencah in frekvenčnih deležih. Za primerjavo med povprečji vadbene in kontrolne skupine v izbranemu testu gibalne učinkovitosti smo uporabili t-test za neodvisne vzorce. Vse obdelave so bile izvedene pri stopnji tveganja 5 %. Ugotovili smo, da vsakodnevna desetminutna vadba pozitivno vpliva na razvoj gibalnih sposobnosti pri zaposlenih v lekarni. Ugotovili smo prav tako, da se zaposleni v lekarnah najpogosteje srečujejo z bolečinami v spodnjem delu hrbta (63 % preizkušancev), kolenih (46 % preizkušancev), v vratu (46 % preizkušancev) in ramenih (42 % preizkušancev). Vpliva vadbe na zmanjšanje bolečin po vadbeni intervenciji nismo ugotovili, saj pred vadbo in po njej ni bilo statistično značilnih sprememb. Ugotovitve in pridobljeni podatki so lahko v pomoč tistim, ki se ukvarjajo z organizacijo vadbe na delovnem mestu, in vsem zaposlenim v lekarnah, ki želijo zmanjšati vpliv nekaterih negativnih posledic stoječe delovne obremenitve. The main aim of the master's thesis was to determine whether daily ten-minute work-out exercises have a positive effect on some movement skills of pharmacy employees. We were also interested in whether pharmacy employees experience pain in certain parts of the body. Twenty-four test subjects were enrolled in the study. We included 16 subjects in the training group, among whom there were more women (81.3%). The control group included 8 subjects in equal proportion by gender. All of them are employed by pharmacies of Javni zdravstveni zavod Mariborske lekarne Maribor. After the institution and the employees agreed to cooperate and after presenting the project, we measured the results of the selected movement tests while making the first measurements before the exercise intervention. The adapted form of the Nordic Musculoskeletal Questionnaire (Franasiak, Craven, Mosaly, & Gehrig, 2014) was used to obtain the data on the musculoskeletal disorders from the employees of the pharmacy. After a seven-week training period, we again measured the results of movement tests and obtained information on musculoskeletal disorders and the incidence of pain in each area of the body. Data was statistically processed in IBM SPSS 21 (SPSS Inc., Chicago, Illinois, USA) and stylistically edited in Microsoft Excel 2016 (Microsoft Corporation, Seattle, Washington, USA). Numerical data was presented with averages and standard errors of the mean, numerical ordinal data was presented with median and standard errors of the median, while descriptive data was presented in frequencies and frequency distributions. A t-test for independent samples was used to compare the training and control group averages in the selected exercise test. All treatments were performed at a 5% risk level. We have found that a daily ten-minute exercise has a positive effect on the development of pharmacy employees’ physical fitness. We also found that pharmacy employees most often experience lower back pain (63% of test subjects), knee pain (46% of test subjects), neck pain (46% of test subjects) and shoulders pain (42% of test subjects). The effect of exercise on pain reduction after exercise intervention was not identified, as there were no statistically significant changes before and after exercise. The findings and data obtained can be of assistance to those involved in the organization of workplace exercise and to all pharmacy employees who wish to reduce the impact of some of the negative effects of the standing work position.

Diplomsko delo obravnava izdelavo samostojne avtomatske opazovalnice živali s pomočjo računalnika Raspberry Pi. Najprej je predstavljena oprema, ki smo jo potrebovali pri izdelavi opazovalnice. Glavna strojna oprema je enoploščni računalnik Raspberry Pi 3 (model B), na katerega smo namestili operacijski sistem Raspbian in programski jezik Python ter nastavili varen oddaljen dostop preko protokola SSH. Nato razložimo, kako smo s pomočjo sončne celice z izhodno močjo 15 W, regulatorja, ter akumulatorja z 12 V napetostjo in kapaciteto 7,2 Ah sestavili napajalni sistem ter nanj povezali računalnik Raspberry Pi s kamero Pi NoIR. V diplomski nalogi predstavimo tudi rezultate avtomatskih opazovanj manjših živali pri različnih pogojih osvetlitve. The thesis describes the creation of an automatic animals observatory with the Raspberry Pi computer. First, we present the components that we used for making of the observatory. The main hardware is comprised of the Raspberry Pi 3 computer that runs the Raspbian operating system as well as the Python programming language and remote access via SSH. The power supply is provided by the 15 W solar panel, regulator, as well as the 12 V battery with 7.2 Ah capacity. Special attention is also paid to minimization of energy consumption by the Raspberry Pi and Pi NoIR camera. Finally, we present the results of automatic observation of smaller animals at varying lighting conditions.

V sodobnem športu je kljub razvoju tehnologije in široki dostopnosti najrazličnejših metod treningov še zmeraj pomanjkljivo razvito področje identifikacije talenta. Zaradi manjše količine nepredvidljivih dejavnikov in položajev, ki neposredno vplivajo na uspešnost v atletiki kakor tudi v atletskih metih, je na tem področju nekoliko lažje določiti testno baterijo gibalnih sposobnosti, ki jih je potrebno opazovati in preučiti, da lahko določimo, katere od njih imajo največji vpliv na uspešnost meta. Na podlagi tega predvidevamo, kateri atlet bo dosegel najboljši rezultat. V uvodu diplomskega dela vam bomo podrobneje predstavili disciplino atletskih metov. Posebno pozornost smo namenili suvanju krogle. Navedli in opisali smo dejavnike, ki v največji meri določajo dolžino meta. Podrobno smo predstavili tudi linearno in rotacijsko tehniko suvanja krogle. V nadaljevanju smo raziskali pomen besede talent v športu, kakšna je razlika med nadarjenostjo in talentom in kako so se nekatere države že lotile identifikacije talentov. Upoštevali smo tudi področja biološkega razvoja otrok in starostnih obdobij, ki jih bomo primerjali v raziskovalnem delu. V diplomskem delu smo obravnavali predpubertetno in pubertetno obdobje, saj smo želeli ugotoviti povezanost nekaterih morfoloških značilnosti, specifičnih in osnovnih gibalnih sposobnostih v skupini atletov predpubertetnega obdobja (U 10) in skupini atletov pubertetnega obdobja (U 14). Prav tako nas je zanimala povezanost rezultatov med starostnima skupinama. V letu 2015 smo izvedli raziskavo »Ekspertno modeliranje izbora mladih atletov« Fakultete za šport v sodelovanju Atletske zveze Slovenije, s katero smo pridobili podatke, uporabljene v raziskovalnem delu diplomskega dela. Podatke smo statistično obdelali z računalniškim programom IBM SPSS Statistics 22. Hkrati smo izvedli test linearne regresije in Pearsonovo korelacijo. Grafično smo podatke predstavili s programom Microsoft Excel 2016. Rezultate smo predstavili z izračunom enačbe linearne premice. Izračunali smo vrednost determinacijskega koeficienta R2. Za primerjavo smo uporabili še vrednost korelacijskega koeficienta Pearsonove korelacije. Na podlagi dobljenih rezultatov smo ugotovili, da nekatere morfološke mere, specifične gibalne in osnovne gibalne sposobnosti, kažejo na visoko povezanost in v veliki meri pojasnjujejo uspešnost sunka težke žoge. Spet druge morfološke mere, specifične gibalne in osnovne gibalne sposobnosti kažejo nizko povezanost in v majhni meri pojasnjujejo uspešnost metov, nekatere pa so celo statistično neznačilne. Despite development of techniques and broad accessibilty of variety of different methods of training there is still a lack of development on the field of talent indentification in contemporary sports. Due to smaller amount of unpredictable factors and situations which indirectly affect success in athletics, also in throws, on this field is slightly easier to determine test battery of movement abilities which should be monitored and studied in a way to recognize which of them have the biggest influence on success in this category. In such a way we would be able to predict which athlete would achieve the best score. In the introduction of diplome thesis we would like to present the discipline of throws. Special attention we granted to the shot puts. We stated and described factors, which have the greatest influence on length of the throw. We presented linear and rotation technique of shot puts. In the following we reshearched meaning of the word talent in sports. More accurately what is the difference between being gifted and having talent and how some countries have begun to research identification of talent. We also looked into biological development of children and ther age periods which we have compared in research part. Through diplome thesis we tried to determine connection of some morphologic features, specific and basic movement abilities in athletes before puberty (U 10) and in athlets in puberty (U 14). We also studied connection of the results between age groups. In year 2015 we carried out the research titled Expert modelling of choosing of young athletes. Research was carried out on our faculty in connection with Athletic federation of Slovenia. They provided us with data which we used in our research part. We processed our data with SPSS statistics 22, we carried out test of linear regression and Pearson correlation. Grafic representation we did with Microsoft Excel 2016. We presented our results with calculation on linear line. We also calculateed value of determination coefficient. For comparison we also used value of correlation coefficient of Pearson correlation. We found out that connection of morphologic features, basic and specific movement abilities point at high connectivity and in to a large extent explain success at throws. Some morphologic measures, specific and basic movement abilities show low connectivity and in smaller extent explain sucess at throws, some are also statisticly nonsignificant.

V magistrski nalogi so obravnave uspešnice, to so knjige, ki na tržišču v kratkem času dosežejo nadpovprečen uspeh oziroma dobiček. Analizirane so z vidika trženja in umetniške vrednosti. Osnova trženja je razložena v poglavju o literarnem sistemu, ki literaturo obravnava kot avtonomen družbeni sistem, pri čemer ELZ raziskovanje usmerja od avtorjev in literarnih besedil k vsem dejavnostim, ki so povezane s teksti, teorija literarnega polja pa uvaja pojem simbolnega kapitala, s katerim je mogoče razložiti objektivna razmerja med udeleženci literarnega polja. Trženje literature zaznamujejo različni dejavniki (aktualnost teme, blagovna znamka avtorja, zunanjost knjige, promocija, kritike, nagrade), katerih učinkovitost je obravnavana pri analizi izbranih prodajnih uspešnic. Raziskana je tudi literarna plat uspešnic, pri čemer je deloma potrjena teza, da med njimi ni mogoče najti literature z umetniško vrednostjo, saj trg zaradi naravnanosti k množični potrošnji obvladuje trivialna književnost. Slovenski prostor zaznamuje še ena posebnost, to je velika razlika med prodajnimi in izposojanimi uspešnicami, saj se okoli splošnih knjižnic in knjigarn razvijata dva precej različna knjižna ekosistema. Manjši del pozornosti je zato namenjen tudi uspešnicam, ki obvladujejo sezname izposoje. Master's thesis deals with bestsellers, meaning books that achieve within a short period of time above-average success or profit. They are analysed within the aspects of marketing and literary value. A basis of the marketing gets explained in the chapter about literary system which deals with literature as an autonomous social system, in conjunction with which the ELZ research guides from authors and literary works to all activities connected to texts whereas, the theory of literary field introduces the concept of symbolic capital, with which it is possible to explain objective ratio among participants of literary field. Marketing of literature is characterised by various factors (important topics, trade mark of an author, an exterior of a book, promotion, criticism, awards) which efficiency gets discussed within the analysis of chosen bestsellers. A literary context of bestsellers is also researched, where one hypothesis gets partly confirmed. This hypothesis claims that, among bestsellers, one cannot find literature with literary value, because the market, with its stance towards large-scale consumption, is controlled by trivial literature. The Slovene area is characterised by another speciality, this is the large difference between sold and borrowed bestseller, since in and around general libraries and book stores the two quite different book ecosystems are getting developed. A small part of attention is for that reason also given to the bestsellers that prevail on the lists of borrowed books.

Mobing je kompleksen in dinamičen pojav, ki močno prizadene posameznika ozir. žrtev psihično in fizično. Je kaznivo dejanje, ki je opredeljeno v številnih zakonih in pravnih predpisih. Mobing pomeni kršitev človekovih pravic. Operacijsko okolje je specifično okolje, z zgodovinsko opredeljeno hierarhijo vodenja in organizacijo dela. Raziskovana metodologija: Raziskava je temeljila na kvantitativni metodologiji, kot raziskovalni instrument smo uporabili anketni vprašalnik, ki je vseboval 19 vprašanj zaprtega tipa in eno odprtega tipa. Raziskovalni vzorec je zajemal izvajalce operativne dejavnosti v operacijskih dvoranah Univerzitetnega kliničnega centra Maribor. Namen raziskave je bil ugotoviti prisotnost mobinga v operacijskem okolju, njegove oblike, najpogostejše žrtve, razloge za nastanek ter posledice. Rezultati raziskave: Ugotovili smo, da je vzrok mobinga v slabi komunikaciji, nedorečeni organizaciji dela ter trenutnem družbenoekonomskem položaju družbe kot celote. Razprava in sklep: Iz raziskave je razvidno, da zaposleni poznajo in prepoznavajo mobing ter postopke obravnave oziroma preprečevanja nastanka mobinga. Vedo, da dobra komunikacija med potencialnim povzročiteljem mobinga in žrtvijo lahko prepreči, da do teh dejanj ne pride. Da bi ta pojav v operacijskih dvoranah zmanjšali, zaposleni morajo izboljšati način medsebojne komunikacije in v usposabljanje uvesti tudi antistresne programe. Z uvajanjem novih kadrov in z razbremenitvijo ukvarjanja z deli za katere niso kompetentni, bi učinkovito zmanjšali mobing. Hkrati bi zaposleni prevzeli svoj del odgovornosti v procesni obravnavi bolnika, učinkovito izboljšali komunikacijo, dvignili raven samozavesti in spoštovanja posameznika, kakovost obravnave bolnika ter organizacije dela v zdravstvu. Mobbing is a complex and dynamic phenomenon that significantly affects an individual or victims: psychological and physical. It is a criminal offense, which is defined in a number of laws and regulations. Mobbing is a violation of human rights. Operating environment is a specific environment, with historically defined hierarchy of management and organization of work. Studied Methodology: The study was based on a quantitative methodology as a research tool we used a questionnaire that contained 19 questions, closed and one open type of question. The research sample consisted of operating activities performers in the operating room at the University Medical Centre Maribor. The purpose of this study was to evaluate the prevalence of mobbing in the operating environment, its forms, the most common victims, the reasons for the occurrence and consequences. Survey results: We found that the causes of mobbing are in the lack of communication, vague organization of work and the current socio-economic situation of society as a whole. Discussion and conclusion: The survey shows that employees are aware of mobbing and that they recognize bullying as well as the procedures for treatment or prevention of occurrence of mobbing. They know that good communication between the potential perpetrator and the victim of mobbing can prevent that these acts do not occur. In order for this phenomenon to be reduced if not prevented, they must improve the way employees communicate with each other with training and also with an introduction of anti-stress programs. With the introduction of new staff and with strain relief of dealing with parts for which they are not competent, bullying would be effectively reduced. At the same time employees would assume their share of responsibility in the patient’s treatment process, effectively improve communication, boost self-confidence and respect for the individual, as well as the quality of the patients care and the organization of healthcare work.

Internet je od svojega razvoja dolgo časa obstajal kot prostor za enostransko komunikacijo. Isto se je dogajalo na televiziji, radiu in časopisih, kjer je javnost sprejemala informacije, ki jih je nekdo pripravil. Tradicionalni mediji so hitro doumeli, da takšna vrsta komunikacije ni naravna in ne predstavlja najboljšega ohranjanja gledalcev in poslušalcev. Začela se je uporabljati dvosmerna komunikacija. Trenutno v svetu najbolje poznan primer dvosmerne komunikacije je socialno omrežje Facebook, katerega ustanovitelj je Mark Zuckerberg. Socialna omrežja so spletni portali, ki omogočajo druženje s sebi podobnimi, prijatelji, znanci in neznanci. Facebook, kot omrežje, , ljudje uporabljajo za zabavo, komunikacijo s prijatelji, objavljanje fotografij, komentiranje in splošno brskanje. Slovenci smo po številu uporabnikov Facebooka na triinosemdesetem mestu in smo za primerjavo pred Kitajci. Od socialnega omrežja Facebook imajo veliko korist tudi podjetja, ki na njem oglašujejo. Facebook jim namreč omogoča oglaševanje preko oglasov in oglaševanje na svoji strani na Facebooku. Oglaševanje s pomočjo oglasov je plačljiva oblika oglaševanja, oglaševanje na Facebook strani pa je brezplačna. Dobro oglaševanje ima tudi Spleticna.si, ki kombinira s klasičnim in spletnim oglaševanjem. Govorimo o podjetju, ki se ukvarja s spletno trgovino, kar pomeni, da nima osebnega stika z odjemalci. Facebook je prvi medij, ki jim je to omogočil. Preko Facebooka lahko komunicirajo s svojimi privrženci in tako gradijo na zaupanju ljudi do njihovega podjetja. Since its development internet has been a space for one way communication. The same trend has occurred on television, radio and in the newspapers, where already written texts were presented to public who accepted them but could not respond. The media has quickly grasped, that this is not the way to preserve the audience. The two-way communication was born. The best known example of two-way communication is social network Facebook which was created by Mark Zuckerberg. Social Networks are Web portals which allow us to be in on-line contact with our friends, our acquaintance or with people that we do not know. People use Facebook for entertainment, communication with friends, publishing photos and basic browsing. The enterprises can take big advantage from Facebook by publishing their advertisements for free. Facebook allows them to publish an advert on their “Facebook enterprise website”. This is the best way to publish their advertisements for free. Spletnicna.si is the example of advertising on Facebook. They combine classic and web advertisement. This is the company that occupy with on-line shop and they are not in touch with their customers but Facebook is the first media that make that possible for them. Through Facebook they can communicate with their costumers and build a trust in their enterprise.

Vloga medicinske sestre pri izvajanju preventive pred zoonozami je bil izziv za izdelavo diplomskega dela. Opisali smo številne naloge, ki jih medicinska sestra opravi v okviru cepljenja pred nalezljivimi boleznimi, ki jih povzročajo zoonoze in v okviru zdravstvene vzgoje z upoštevanjem potreb posameznika. Zoonoze so bolezni živali, ki se lahko prenašajo na človeka preko fecesa, mesa, mleka, jajc in ostalih izločkov. Boj zoper zoonoze terja poleg zdravljenja bolezni še posebne obsežne ukrepe pri zatiranju teh bolezni. Najučinkovitejši preventivni ukrep pred zoonozami je vsekakor cepljenje. Cepljenje (vakcinacija) je poseg v človekov organizem, s katerim z vnašanjem antigena v telo sprožimo tvorbo protiteles proti določeni nalezljivi bolezni. Je najučinkovitejši ukrep za preprečevanje, obvladovanje in zatiranje bolezni. V Sloveniji je cepljenje obvezno in se sistematično in kontinuirano izvaja v skladu s predpisano zakonodajo. V diplomskem delu smo predstavili vlogo medicinske sestre pri izvajanju ukrepov za preprečevanje zoonoz v Sloveniji. Prav tako smo preučili izbrane zoonoze, ki se pri nas najpogosteje pojavljajo, za pet letno obdobje. Te bolezni, ki jih povzročajo zoonoze, so steklina, tetanus, leptospiroza in vročica q. Dobljene rezultate smo preučili in grafično prikazali. Rezultati raziskave so pokazali, da so nekatere zoonoze še vedno v porastu. Pogostost pojavljanja je zelo različna glede na posamezno bolezen in posamezno območje po Sloveniji. Tetanus se najpogosteje pojavlja na območju Celja, leptospiroza na območju Murske Sobote, Ljubljana pa izstopa po pojavljanju vročice q. The role of a nurse in zoonosis prevetion makes the central theme of our graduation thesis, in which we provide a detailed description of the numerous tasks a nurse has to perform in the course of vaccination against contagious diseases caused by zoonoses, as well as the tasks performed for the sake of health education with regard to the needs of individual people. Zoonoses are animal diseases that can be transmitted from animals to humans through feces, infected meat, eggs, as well as other excrements. The struggle against zoonoses involves – apart from the very medical treatment of the infected and sick patients going on in the process – other special broad and far-reaching measures aimed at fighting the disease itself. It is vaccination, however, which is generally considered to be the most effective preventive measure against zoonotic diseases. Vaccination is the administration of antigenic material into a human body, where this very antigenic material triggers the production of antibodies against a particular contagious disease. Vaccination makes the most effective disease-prevention, disease management, and disease elimination measure. In Slovenia vaccination is compulsory and is practiced systematically and continuously according to the legislation. In our graduation thesis we tried to present the role of a nurse in taking preventive measures against zoonoses in Slovenia. We examined the appearance of the chosen zoonoses as they appeared in Slovenia in a five-year-period. The diseases caused by zoonotic pathogens in Slovenia include rabies, tetanus, leptospirosis, and fever. We made a thorough examination of the results we received, and displayed the data in a graphical form. Results of our studies show that some zoonoses have still been on an increase. The frequency of zoonotic diseases varies according to each particular disease and to each individual area within Slovenia. Tetanus has most frequently been observed in the area around the town of Celje, whereas cases of leptospirosis have most frequently been reported from the area around the town of Murska Sobota, while the area around Ljubljana is notorious for its cases of Q fever.