1. Advances in the Immunobiological Therapies for Advanced Melanoma.
- Author
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Pérez Gago MC, Saavedra Santa Gadea O, and de la Cruz-Merino L
- Subjects
- Antibodies, Monoclonal adverse effects, Antibodies, Monoclonal immunology, Antibodies, Monoclonal pharmacology, Antibodies, Monoclonal therapeutic use, Antigens, Neoplasm immunology, Antineoplastic Agents adverse effects, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, B7-H1 Antigen antagonists & inhibitors, B7-H1 Antigen immunology, CTLA-4 Antigen antagonists & inhibitors, CTLA-4 Antigen immunology, Clinical Trials as Topic, Forecasting, Humans, Immunologic Factors pharmacology, Immunologic Factors therapeutic use, Lymphocyte Activation drug effects, Lymphocyte Activation immunology, Lymphocytes, Tumor-Infiltrating drug effects, Lymphocytes, Tumor-Infiltrating immunology, MAP Kinase Signaling System drug effects, Melanoma immunology, Melanoma secondary, Neoplasm Proteins antagonists & inhibitors, Programmed Cell Death 1 Receptor antagonists & inhibitors, Programmed Cell Death 1 Receptor immunology, Protein Kinase Inhibitors pharmacology, Protein Kinase Inhibitors therapeutic use, Salvage Therapy, T-Lymphocytes drug effects, T-Lymphocytes immunology, Tumor Escape drug effects, Tumor Escape immunology, Immunotherapy methods, Melanoma therapy, Molecular Targeted Therapy methods
- Abstract
Metastatic or locally advanced unresectable melanoma carries a high morbidity and mortality. However, notable advances have been made in recent years in the systemic treatment of this disease, with the appearance of targeted therapy using tyrosine kinase inhibitors that block the mitogen activated protein kinase pathway, and of modern immunotherapy with immune-modulating monoclonal antibodies. In this paper, we provide an update of available data on new immune therapies and we review the clinical development that led to their approval for use in routine clinical practice., (Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2017
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