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Background: The Cissus sicyoides, popularly called insulin plant, the drink is widely used in folk medicine to control glycemia. However, there are not enough datas about the effect of Cissus sicyoides on bone physiology. Thus, the goal was evaluate the glycemia and femur parameters in male rats. Material and methods: Wistar male rats with 12 weeks were divided control group (C) and treated with 5% of Cissus sicyoides (CS). After 42 days of treatment the groups were sacrificed and the body mass (g), glycemia, body organs and femur parameters were assessed. Results: In the last week the CS group showed significantly lower body mass and lower glycemia. After 42 days the CS showed heart and liver mass were significantly lower. In regard to bone paramaters, the mass and BMD of femur were significantly lower in CS group. Conclusions: Despite the Cissus sicyoides drink decrease the glycemia, nevertheless it intake does not seem unfavorable for bone parameters.

Diabetes is a complication which occurring during gestation might substantially influence the development of offspring during fetal life and postnatally. Flaxseed is a source of omega-3, that the appropriate supply during gestation and lactation are determinant for a suitable perinatal growth and development. The present study aimed to assess beneficial effects of the use of flaxseed flour during pregnancy and lactation on body development from birth to weaning of offspring from diabetic mothers. Methods: twelve rats from a total of eighteen were induced to diabetes by high-fat diet during four weeks, also receiving one lower dose of streptozotocin. After confirmation of diabetes (glucose>300mg/dL), they were mated and when pregnancy was confirmed, they were divided in 3 groups: high-fat group (HFG), high-fat flaxseed flour group (HFFFG) and control group (CG), receiving high-fat diet, high-fat diet added flaxseed flour and control diet, respectively. They were fed this way during whole gestation and lactation. The body development of offspring was measured weekly since the first day after birth until weaning. Results: At birth, the average body mass of offspring from diabetics mothers who received only high-fat diet was 23,6% lighter than body mass of offspring from non-diabetics mothers (p