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A new fossil bird is described from the Upper Lumbrera Formation of Northwestern Argentina. Lumbrerornis rougieri gen. et sp. nov. is represented by three-dimensionally preserved elements of the hindlimb of a single individual. Morphological comparative studies and particular characters of the tibiotarsus suggest that the new species might be related to the extinct clades Palaeotididae and Geranoididae of the Northern Hemisphere, which were recently hypothesized to be Paleogene palaeognathous birds. However, the fragmentary preservation of the new fossil prevents a confident systematic position. The Upper Lumbrera Formation is a widely recognized fossiliferous unit with a very rich fauna of mammals and other vertebrates (e.g., fishes, crocodilians, turtles, snakes). This is the first record of a three-dimensionally preserved fossil bird from the Eocene of northwestern Argentina and thus provides fresh evidence of the Eocene faunas from the area and improves our understanding of the poorly known early Paleogene avifaunas from South America.

Background: Attachment theory represents one of the most important references for the study of the development of an individual throughout their life cycle and provides the clinician with a profound key for the purposes of understanding the suffering that underlies severe psychopathologies such as eating disorders. As such, we conducted a cross-sectional study with a mixed-methods analysis on a sample of 32 young women with anorexia nervosa (AN); this study was embedded in the utilized theoretical framework with the following aims: 1. to evaluate the state of mind (SoM) in relation to adult attachment, assuming a prevalence of the dismissing (DS) SoM and 2. to analyze the linguistic attachment profile emerging from the transcripts of the AAIs. Methods: Interviews were transcribed verbatim, coded, and analyzed using the linguistic inquiry and word count (LIWC) method. Results: The results were observed to be consistent with the referenced literature. The prevalence of a DS SoM (68.75%) is observed in the study sample, whereas the results of the lexical analysis of the stories deviate from expectations. Notably, the lexical results indicate the coexistence of the dismissing and entangled aspects at the representational level. Conclusions: The study results suggest a high level of specificity in the emotional functioning of patients with AN, with a focusing on a pervasive control of emotions that is well illustrated by the avoidant/ambivalent (A/C) strategy described in Crittenden’s dynamic–maturational model. These findings and considerations have important implications for clinical work and treatment, which we believe must be structured on the basis of starting from a reappraisal of emotional content.

ABSTRACT Introduction: thyroid surgery through the transoral vestibular approach is a reality in many countries. While several competing remote access techniques have been developed in the last 20 years, many were not reproducible. Transoral Endoscopic Neck Surgery (TNS) has been shown to be reproducible in different centers around the world, and approximately five years after its description it has been adopted relatively quickly for various reasons. To date, there are at least 7 Brazilian studies published, including a series of more than 400 cases. The aim of this work is to study the progression of Transoral Neck Surgery in Brazil and describe the profile of surgeons involved in this new approach. Methods: this is a retrospective study with descriptive statistics. A REDCap based survey about transoral endoscopic thyroidectomy and parathyroidectomy vestibular approach (TOETVA/TOEPVA) was done with 66 Brazilian surgeons regarding surgeon profile, numbers of cases performed by geographic region, what kind of training was necessary prior to the first case and behavior of the surgeon proposing these new approaches. Results: response rate of this survey was 53%. To date, 1275 TOETVA/TOEPVA cases had been performed in Brazil, 1229 thyroidectomies (96.4%), 42 parathyroidectomies (3.3%) and 4 combined procedures (0.3%). Most of the cases were done in the southeast region (821, 64.4%), 538 (42.2%) cases in the State of São Paulo and 283 (22.2%) cases in the State of Rio de Janeiro. Conclusions: TOETVA is becoming popular in Brazil. Younger surgeons, especially those between 30 and 50 years old were more likely to adopt this approach.

THE USE OF HYBRID OR NANOCOMPOSITE MATERIALS AS STEEL ANTICORROSIVE COATINGS. The search had as the goal to present and reflect the hybrid materials as an alternative for anticorrosive coatings of metallic surfaces, such as steel. For comparison purposes, different types of anti-corrosion coatings capable of protecting metallic surfaces, such as steel, from oxidation action were presented. Steel is a metallic material widely used by industry in different types of segments, and its corrosion is a pathology responsible for its functional loss, causing losses in its use. Through a qualitative, bibliographic and exploratory research, based on academic works, it was presented that hybrid materials or nanocomposites prove to be efficient as anticorrosive coatings capable of protecting steel against oxidation.

ABSTRACT Objective To describe the risk factors for cardiovascular diseases and the quality of life of first-year college students. Methods A cross-sectional study conducted with first-year undergraduate nursing students attending a public university located in São Paulo, Brazil. The students completed nine questionnaires and the students’cervical and abdominal circumferences were measured along with their weight and height, blood pressure, lipid profile, and capillary blood glucose. Results 67 undergraduate students were included. Half of the students were physically inactive (73.1%), 7.5% reported smoking, 40.3% alcohol consumption, 25.4% overweight, and 16,4% increased total cholesterol. Depressive symptoms, anxiety, and stress were also reported, as well as excessive daytime sleepiness, risk of sleep apnea, and risky and harmful consumption of alcohol. As for the quality of life, the domains with the lowest scores were vitality and emotional aspects. Conclusion The most prevalent risk factors found in undergraduates were sedentary lifestyle, excessive daytime sleepiness and stress.

Colour reflects the “fluid” nature of the image: both can be considered as a factual, objective evidence of the external world as well as a subjective and sometimes deceptive re-representation of it. The section entitled “Colour. Photography, Image, Reality” collects essays that widely investigate the power of colour to unfold new sensibilities and practices linked the fruition, the creation and the use of images, across very different media: from literature to social media. The authors develop some core themes, such as the aesthetics of colors, the relevance of intermediality to comprehend specific experiences, and the epistemological and political implications of color technology. The reflections on images encounter the philosophical debate on colour, offering the opportunity to examine every pattern of recognition (that can be ours or of others, human or non-human) and contributing to the discussion on the contingent and questioning relationship between image and reality.

A diarreia é considerada um sinal clínico bastante comum na clínica de animais de companhia, sendo que o uso de nutrientes imunomoduladores no tratamento deste quadro é considerado uma nova modalidade terapêutica cada vez mais utilizada por médicos veterinários. A suplementação dietética de probióticos, prebióticos e L-glutamina têm mostrado efeitos benéficos no controle e tratamento da diarreia em humanos. Pelas poucas descrições de utilização de imunonutrientes na literatura médico veterinária, este trabalho teve como objetivo relatar o caso de um cão da raça Poodle, fêmea, idade de 13 anos, com quadro de diarreia, submetido ao tratamento com glutamina por via oral durante 5 dias, o que resultou em remissão completa do episódio diarreico.

ABSTRACT OBJECTIVE To estimate the evolution of the prevalence of SARS-CoV-2 virus infection among residents aged 18 years or over in the municipality of São Paulo. METHODS This is a population-based household survey conducted every 15 days, between June and September 2020, and January and February 2021. In total, the study comprised 11 phases. The presence of antibodies against SARS-CoV-2 was identified in venous blood using a lateral flow test, Wondfo Biotech. In the last phase, the researchers combined it with an immunoenzymatic test, Euroimmun. The participants also answered a semi-structured questionnaire on sociodemographic and economic factors, and on social distancing measures. Prevalence estimates and the 95% confidence interval were estimated according to regions, Human Development Index, sex, age group, ethnicity, education, income, and variables associated with risk or prevention of infection. To compare the frequencies among the categories of each variable, the chi-square test with Rao-Scott correction was used, considering a significance level of 5%. RESULTS In total, 23,397 individuals were interviewed and had their samples collected. The estimated prevalence of antibodies against SARS-CoV-2 ranged from 9.7% (95%CI: 7.9–11.8%) to 25.0% (95%CI: 21.7–28.7). The prevalence of individuals with antibodies against the virus was higher among black and brown people, people with lower schooling and income, and among residents of regions with lower Human Development Index. The lowest prevalences were associated with recommended measures of disease protection. The proportion of asymptomatic infection was 45.1%. CONCLUSION The estimated prevalence of the infection was lower than the cumulative incidence variation, except for the last phase of the study. The differences in prevalence estimates observed among subpopulations showed social inequality as a risk of infection. The lower prevalence observed among those who could follow prevention measures reinforce the need to maintain social distancing measures as a way to prevent SARS-CoV-2 infection.

Abstract Hoplias malabaricus is a non-migratory fish commonly found in the Mogi Guaçu River basin, mainly feeding on fish, small crustaceans and insects. It forms part of the diet for humans, birds and some mammals. This fish has great nutritional value, with both good quality and good quantities of essential vitamins and amino acids. Regarding parasitic fauna, this fish can host different species of helminths in its gastrointestinal tract. The aim of the present study was to investigate the possible interference of parasitism in the meat yield from H. malabaricus and the centesimal composition. For this purpose, fish specimens were collected from marginal lagoons of the Mogi Guaçu River (Pirassununga, state of São Paulo, Brazil) using hooks and fishing nets. We found that all specimens of H. malabaricus were parasitized by at least one species, including larvae of Contracaecum sp. (Nematoda: Anisakidae). Parasitism did not have any significant influence on centesimal composition, but meat yield was negatively correlated with the abundance of larvae.

O artigo aborda a experiência de extensão voltada à formação profissional continuada de trabalhadores das políticas de assistência social e de saúde da região catarinense da Grande Florianópolis. Objetiva-se, para além de sua sistematização, analisar e socializar a extensão universitária no âmbito das políticas sociais, desenvolvida a partir de 2015 pelo Núcleo Interdisciplinar de Pesquisa Sociedade, Família e Políticas Sociais. Introdutoriamente se desenvolve os fundamentos históricos e teóricos que sustentam essa experiência; abordam-se aspectos relacionados à sua organização e dinâmica de desenvolvimento, as características dos profissionais envolvidos e, por fim, alguns dos efeitos dessa experiência entre os agentes envolvidos no sentido de ruptura com concepções e práticas que reforçam expectativas e “papéis” tradicionais em relação às famílias e às mulheres, de construção de metodologias interdisciplinares, de mudanças nos serviços ofertados às famílias.

While L2 acquisition by Brazilians has been studied for different languages, the acquisition of Brazilian Portuguese by foreigners has been poorly explored. Recent studies of non-native accented speech in other languages have shown that a foreign accent could largely influence the perception of personal qualities of speakers, and this issue presents a large interest for intercultural research projects. Our research project is focused on Russophone immigrants living in Brazil, bilingual speakers of Russian and Portuguese. The specific aim of the current work is to describe a database containing information about 40 native Russian speakers living in São Paulo for at least six months. Their linguistic and sociocultural profiles are presented, and the experimental protocol of the data collection is described. The protocol included recording speech samples in Russian and in Portuguese and video recordings for further facial expression analysis of bilinguals by the program FaceReader 7.0. The analysis of the sociocultural profiles of the Russophones, presented in the current work, provides a strong basis for the enrichment of the phonetic, sociolinguistic, and nonverbal behavior analysis of these speakers.

Este artigo trata da encenação do musical O homem de La Mancha (Dale Wasserman, 1965) no teatro brasileiro nos anos 1972-1973, produzido por Paulo Pontes e dirigido por Flávio Rangel. O objetivo é compreender a leitura do Quixote como ideal de justiça e liberdade num contexto marcado pelo autoritarismo, sobretudo, em relação à figura do artista/intelectual.

ABSTRACT: We evaluated the effect of frozen storage temperature and thawing methods on acceptance and sensory profile of steaks of Nellore beef strip loin under 30 days of frozen storage. Fresh strip loin (n = 13), collected two days after slaughter, were aged (2 °C) for 14 days and cut into seven steaks subjected to one of the treatments: control (unfrozen), combination of two freezing temperatures (−10 and −20 °C), and three thawing methods (microwave, ambient temperature, and refrigeration thawing). Steaks in the frozen/thawing treatment were frozen using an ultra-fast freezer until the desirable temperature was reached and were stored for 30 days. After cooking, steaks were analyzed by 11 panelists for the Quantitative Descriptive Analysis (QDA®) and by 120 beef consumers for acceptance. Storage temperature and thawing methods showed little or no changes in the sensory quality of strip loin steaks, detected by either panelists or consumers. In the QDA®, apparent juiciness was lower in samples thawed in microwave, while the rancid flavor was lower for samples frozen at −20 °C and thawed in refrigeration ( p < 0.05). The consumer test showed that samples stored at −10 °C and microwave thawing was most accepted in terms of tenderness, juiciness, and overall impression. Fresh steaks (unfrozen) had low acceptance for overall impression in relation to frozen meat. This indicates that consumers could use a household freezer (−10 °C) and quicker thawing methods (microwave or room temperature) without compromising the sensory perception of steaks frozen up to one month.

ABSTRACT: The present study aimed to evaluate the effects of immunocastration on the animal growth, carcass traits, and meat quality of Nellore cattle receiving or not Ionophore supplementation at pasture or pasture with concentrate (semi-feedlot). The first experiment (Pasture) was carried out during the rainy season, while the second (supplemented = Semi-feedlot) was conducted during the dry season. In each assessment, 60 males were allocated into three treatments, in a completely randomized design: non-castrated, immunocastrated (anti-gonadotropin-releasing hormone vaccine), and immunocastrated animals receiving ionophore. The highly energetic supplemented diet was prepared using 85 % corn and 10 % soybean meal at 1 % body weight, while the ionophore was provided with salt containing 1,650 mg kg−1 of lasalocid. After slaughter, the carcasses were graded, and Longissimus thoracis et lumborum samples were collected for meat quality analysis. The non-castrated animals exhibited a more significant final body weight and hot carcass weight than those immunocastrated regardless of ionophore supplementation (p < 0.05). The carcasses of non-castrated animals had less fat cover and marbling than castrated animals. A high incidence of dark cutting beef was verified in non-castrated animals. The immunocastrated cattle produced tenderer beef, mainly at pasture rearing. In conclusion, regardless of production system or ionophore supplementation, immunocastration was an adequate choice to generate high-quality meat, since it increased marbling and improved beef tenderness. However, limitations regarding animal growth should be estimated.

Objetivo: avaliar os fatores que influenciam na adesão de adultos/idosos ao tratamento de hipertensão arterial. Metodologia: pesquisa quantitativa transversal, realizada em duas Unidades Básicas de Saúde, no interior do Paraná, Brasil. Utilizou-se de questionário estruturado para obtenção dos dados sociodemográficos e escala do tipo likert de avaliação do tratamento, sendo a adesão atribuída à pontuação de 73 a 120. A análise foi a partir do software R. O escore de adesão foi descrito pela média, pelo desvio padrão e coeficiente de variação. Para associações entre a adesão ao tratamento, aplicou-se a regressão logística univariada. A pesquisa seguiu os preceitos éticos, obtendo aprovação CAAE: 61218216.8.0000.0106 e parecer Nº 1.838.418. Resultados: participaram do estudo 257 hipertensos, a maioria mulheres. Destes, 91,05% foram aderentes ao tratamento. Não houve diferença significativa entre as Unidades de Saúde. Conclusão: contribuíram para maior chance de adesão: idade superior a 60, aposentado e tempo diagnóstico superior a seis anos. ABSTRACT Objective: to evaluate the factors that influence the adherence of adults / elderly to the treatment of arterial hypertension. Methodology: cross-sectional quantitative research, carried out in two Basic Health Units in the interior of Paraná, in 2016. A structured questionnaire was used to obtain sociodemographic data and a likert scale for assessing treatment, with adherence attributed to a score of 73 to 120. The analysis was based on software R. The adherence score was described by the mean, standard deviation and coefficient of variation. For associations between treatment adherence, univariate logistic regression was used. The research followed the ethical precepts, obtaining CAAE approval: 61218216.8.0000.0106, opinion No. 1.838.418. Results: 257 hypertensive patients, mostly women, participated in the study. Of these, 91.05% were adherent to the treatment. There was no significant difference between the Health Units. Conclusion: They contributed to a greater chance of adherence, being over 60, retired and having been diagnosed for more than six years. RESUMEN Objetivo: evaluar los factores que influyen en la adherencia de adultos / ancianos al tratamiento de la hipertensión arterial. Metodología: investigación cuantitativa transversal, llevada a cabo en dos Unidades Básicas de Salud en el interior de Paraná, Brasil, en 2016. Se utilizó de cuestionario estructurado para obtener datos sociodemográficos y escala likert para evaluar el tratamiento, con adherencia atribuida a puntuación de 73 a 120. El análisis se basó en el software R. La puntuación de adherencia se describió por la media, la desviación estándar y el coeficiente de variación. Para las asociaciones entre la adherencia al tratamiento, se utilizó la regresión logística univariada. La investigación siguió los preceptos éticos, obteniendo la aprobación del CAAE: 61218216.8.0000.0106, opinión No. 1.838.418. Resultados: 257 pacientes hipertensos, en su mayoría mujeres, participaron en el estudio. De estos, 91.05% se adhirieron al tratamiento. No hubo diferencias significativas entre las Unidades de Salud. Conclusión: contribuyeron a mayor probabilidad de adhesión: tener más de 60 años, retirarse y haber sido diagnosticados por más de seis años.

O artigo propõe uma análise do samba do compositor Geraldo Filme. Discuto a perspectiva construída pelos sambas a respeito das estratégias de sobrevivência e enfrentamento ao estigma, agenciados pelos setores sociais marginalizados pela expansão da cidade de São Paulo, Brasil. Argumento que a perspectiva de Geraldo tece uma contranarrativa da história da cidade e de seus grupos marginalizados. Termino por apontar o caráter dissensual da prática social e política inscrita na sociabilidade evocada e na poética praticada pelas canções do sambista. Peddlers, Black-Mothers and Shoe Shiners: The Dissident City of Geraldo Film proposes an analysis of the composer Geraldo Filme’s samba. I discuss the perspective constructed by the sambas regarding survival and clash stigma, intermediated by the marginalized social sectors in the expansion of the city of São Paulo, Brazil. We claim that Geraldo’s perspective weaves a counternarrative of the city and its marginalized group’s history. We conclude by pointing out the dissenting character of the politic and social practices in the evoked sociability and in the poetry from the songs of this composer.Keywords: Geraldo Filme, samba, counternarrative, aesthetics, politics

O espaço urbano é uma construção social que permite interpretações diversas quanto aos seus objetivos, podendo ser destacado um sentido engendrado pelos desígnios da ótica capitalista (cidade-mercadoria) e também outro entendimento deste limite enquanto realização da cidadania e da dignidade social (perspectiva crítica de seus cidadãos). Ao longo deste estudo está colocado um breve relato histórico do surgimento das cidades, bem como a sua concepção urbanística, uma reflexão que evidencia os distintos interesses que se fazem presentes nestes limites. Está destacada a origem da segregação socioespacial do espaço urbano e a ‘naturalização’ com que este processo tem sido considerado nos últimos anos. Através destes levantamentos se questiona as possibilidades que a cidade também pode proporcionar quando pensada pelo enfoque dos sujeitos que estão à margem (os marginais) das objetivações hegemônicas destes espaços. Assim, a proposta desta pesquisa buscou fazer uma reflexão crítica dos processos urbanísticos contemporâneo, trazendo no discurso a necessidade de uma participação ampliada dos cidadãos, incluindo-se aí os ‘favelados’ ou seja, uma efetiva possibilidade de acesso e construção nas diversas materialidades e imaterialidades do meio urbano.

Abstract: The objective of this work was to evaluate the effects of a slower chilling rate on the physical traits of 14-day aged top sirloin (gluteus medius) from F1 Angus x Nellore young bulls. Slight and lean beef carcasses (n = 30) were split in half and selected for control (2°C for 24 hours) and treatment (10°C for 10 hours followed by 2°C for 14 hours). Carcass temperature and pH decline were monitored in the longissimus dorsi (LD). Sarcomere length, color, and instrumental tenderness (Warner-Bratzler shear force and Volodkevich bite jaws) were measured on the gluteus medius (GM). pH 6.0 was reached when the LD temperature was very low, 3°C for the control and 6°C for the treatment. Differences in color and cooking losses were not significant. A trend was noticed for shorter sarcomere length and greater Warner-Bratzler shear force in the GM control. However, a lower value for Volodkevich bite jaws was found in the GM subjected to the treatment. The cooling regimes adopted were not sufficiently different to cause changes in color traits; however, the slow chilling of carcass improved tenderness and can be a good alternative to produce high-value cuts.

El carcinosarcoma es una neoplasia maligna caracterizada por presentar elementos epiteliales y mesenquimales entremezclados. Caso clínico. Paciente varón intervenido quirúrgicamente en nuestro Servicio con diagnóstico de carcinosarcoma sincrónicos de vesícula y vía biliar. Realizamos una puesta al día de esta entidad patológica. Discusión. La extensión del carcinosarcoma de vesícula biliar por continuidad a la vía biliar, ha sido descripta excepcionalmente y es extremadamente infrecuente la localización aislada en la vía biliar principal, y único, como en nuestro enfermo, de manera sincrónica. Un diagnóstico de sospecha preoperatorio permitiría un tratamiento quirúrgico radical evitando un pronóstico desalentador.

RESUMO O gênero Brunfelsia possui ainda poucas informações a respeito de sua composição química ou confirmações científicas de suas propriedades medicinais, apesar do uso na medicina tradicional pelos povos amazônicos. Este trabalho buscou caracterizar a espécie Brunfelsia cuneifolia, cultivada no estado do Rio Grande do Sul, quanto a sua composição química e atividade biológica. Foram obtidos extratos aquosos a quente, a frio, e por ultrassom, a partir de folhas frescas. A caracterização química realizada por CLAE determinou a presença dos compostos fenólicos: ácido ferúlico e rutina, em todos os extratos, sendo as maiores quantidades apresentadas pela extração a frio. A análise por EMAR identificou a fórmula molecular de nove substâncias nos diferentes extratos, incluindo a presença do alcaloide brunfelsamidina em todos os extratos obtidos. Para a atividade biológica, devido à similaridade de resposta e teor nas diferentes formas de extração, foi possível correlacionar a atividade antioxidante, avaliada através da redução do radical DPPH*, com o teor de compostos fenólicos totais obtidos pelo método de Folin-Ciocalteu. A toxicidade dos extratos avaliada pela utilização de Artemia salina revelou ausência de toxidez. Os resultados obtidos são os primeiros apresentados para a caracterização desta espécie, colaborando também para a pesquisa científica acerca dos usos popularmente atribuídos ao gênero.

A cultura da cana-de-açúcar no Estado de São Paulo está se expandindo cada vez mais, buscando atender a demanda por açúcar e etanol. Sendo assim, nas áreas nas quais são cultivadas tradicionalmente, como na região de Ribeirão Preto, SP, o potencial de expansão para o seu cultivo está diminuindo, fato que aumenta a procura por terras. Atualmente, as questões ambientais no Brasil vêm destacando-se em busca de preservar o meio ambiente em relação às queimadas de cana-de-açúcar e à conservação das Áreas de Preservação Permanentes (APPs). Para a prática de colheita mecanizada, a declividade máxima que é viável às colhedoras do mercado é de 12%. A escolha do município de Suzanápolis, SP, justifica-se pelo fato dessa região apresentar baixa rentabilidade agrícola e ser coberta praticamente por pastagens. Com isso, o presente trabalho teve como objetivos, por meio de sensoriamento remoto, de geoprocessamento e do software SPRING® /INPE, identificar as áreas com a cultura da cana-de-açúcar de acordo com classes de declividade, avaliando o potencial de expansão dessa cultura na região e de áreas aptas à mecanização. Buscou-se, também, avaliar o nível de conservação da rede de drenagem e verificar se há cultivo de cana-de-açúcar em Áreas de Preservação Permanente.

OBJETIVO: Avaliar a frequência da mutação V600E do gene BRAF em pacientes com mais de 65 anos de idade submetidos à tireoidectomia, correlacionando sua presença ou ausência com as diferentes lesões histológicas, com as variantes e com fatores prognósticos do carcinoma papilífero. MÉTODOS: Foram avaliados 85 pacientes com mais de 65 anos de idade submetidos à tireoidectomia, analisando a mutação BRAF V600E através de reação de PCR-RT realizada após a extração do DNA dos blocos de parafina. RESULTADOS: Detectou-se ausência ou presença da mutação BRAF V600E em 47 pacientes (55,3%). Entre os 17 carcinomas papilíferos estudados, sete apresentavam a mutação (41,2%). Demonstrou-se associação estatística entre a presença desta mutação e a variante clássica do carcinoma papilífero, além de tendência de associação com o extravasamento tireoideano. CONCLUSÃO: A mutação BRAF nos pacientes idosos também é exclusiva do carcinoma papilífero e tem frequência expressiva. Além disso, está relacionada à variante clássica e, possivelmente, ao extravasamento tireoideano.OBJECTIVE: To evaluate the frequency of the BRAF V600E mutation in patients over 65 years of age undergoing thyroidectomy, correlating its presence or absence with the different histologic lesions, their variants and with prognostic factors of papillary carcinoma. METHODS: We evaluated 85 patients over 65 years of age who underwent thyroidectomy, analyzing the BRAF V600E mutation by RT-PCR performed after DNA extraction from the paraffin blocks. RESULTS: The study detected the presence or absence of BRAF V600E mutation in 47 patients (55.3%). Among the 17 papillary carcinomas studied, seven had the mutation (41.2%). There was a statistical association between the presence of this mutation and the classic variant of papillary carcinoma, and a trend of association with thyroid extravasation. CONCLUSION: BRAF mutation in the elderly is also exclusive of papillary carcinoma and is often significant. Furthermore, it is related to the classic variant and possibly to thyroid extravasation.

Este artigo realiza uma reflexão acerca da dimensão política da estética do RAP. A partir de aspectos físicos e sociais do processo de expansão urbana e de periferização da cidade de São Paulo, procede-se à análise de trechos de composições do grupo de RAP Racionais MC's. Busca-se analisar a inserção de sua poética nos conflitos envolvidos no confrontamento entre "centro" e "periferia", enquanto categorias negociadas na dinâmica conflitiva de relações sociais do espaço urbano. Finaliza-se apontando - na tensão que se observa, por um lado, na relação do RAP com a ordem institucional do Estado, e, por outro, com a dinâmica do "mundo do crime" - o ponto social e poético em que reside a força e a ambiguidade do potencial político de sua estética.This article reflects on the political dimension of the aesthetics of RAP. The study focuses on both physical and social aspects of the processes of urban expansion and peripheralization in the city of São Paulo, based on the analysis of excerpts of songs from the RAP group Racionais MCs. We seek to analyze the insertion of their poetry in confrontation between "center" and "periphery" as categories negotiated in the conflictive dynamics of social relations in the urban space. The article concludes noting the tensions established in the relations of RAP with, on the one hand, the institutional order of the State and, on the other hand, the dynamics of the "criminal world", and pointing out the social and the poetic features in which lie both the strength and the ambiguity of the political potential of its aesthetics.

Existem diferenças metodológicas na literatura acerca da medida de atividade física referente à fragilidade. Assim, o objetivo do presente estudo foi investigar relações entre fragilidade e medidas de atividade física. O estudo teve uma amostra probabilística de 689 idosos (72,28 ± 5,40 anos; 68,21% mulheres). Foi utilizada versão adaptada do Minnesota Leisure Time Physical Activity Questionnaire e estabelecidos dois critérios para as medidas de atividade física: prática regular de exercícios físicos e taxa semanal de gasto calórico em exercícios físicos e em atividades domésticas. Quanto à pontuação, 15,09% dos idosos pontuaram em perda de peso; 17,13%, em fadiga; 16,96%, em baixa força de preensão; 15,87%, em lentidão de marcha; 43,02%, em comorbidades. A frequência de ativos pelo critério de gasto calórico foi de 83,55%; por prática de exercícios físicos, 45,27%. Houve associações entre baixo nível de gasto calórico e baixa força de preensão, lentidão de marcha e idade avançada; entre sedentarismo quanto à prática de exercícios físicos e comorbidades. A medida conforme gasto calórico foi mais sensível aos indicadores de fragilidade, e a medida conforme prática de exercícios físicos, ao estado de saúde.The literature shows methodological differences in measuring physical activity in relation to frailty in the elderly. Therefore, the aim of the present study, part of FIBRA (the Frailty in Brazilian Elderly study), was to investigate relationships between frailty and measurements of physical activity. The study used a probabilistic sample of 689 elderly (72.28 ± 5.40 years; 68.21% women). An adapted version of the Minnesota Leisure Time Physical Activity Questionnaire was used and two criteria were established for measuring physical activity: regular physical exercise and weekly calorie expenditure during physical exercise and household activities. Of the total sample, 15.09% scored on weight loss, 17.13% on fatigue, 16.96% on low grip strength, 15.87% on slow gait, and 43.02% on comorbidities. According to the calorie expenditure criterion, 83.55% of the elders were classified as active, as compared to 45.27% according to the physical activity criterion. Low calorie expenditure was associated with low grip strength, slow gait, and advanced age. Sedentary lifestyle (limited physical activity) was associated with comorbidities. Calorie expenditure was more sensitive for measuring frailty, while physical activity was more sensitive for measuring health status.

Objetivou-se avaliar o efeito do uso de monensina, complexo de leveduras, ácidos graxos poliinsaturados e aminoácidos no consumo de matéria seca e nutrientes, na estimativa da digestibilidade ruminal, nos parâmetros de fermentação ruminal (pH, concentração de nitrogênio amoniacal e de ácidos graxos de cadeia curta), na população de protozoários e na produção de metano. Foram utilizados seis bovinos e com peso corporal de 530 ± 15 kg, recebendo complexo de leveduras, ácidos graxos poliinsaturados e aminoácidos (5 g/dia); monensina (5 g/dia); caulim (5 g/dia), usado como controle adicionado à dieta composta de feno de capim-tifton 85 (Cynodon spp.); e concentrado, na relação 80:20. O delineamento experimental adotado para análise do consumo e da digestibilidade foi o de blocos completos casualizados e, para análise dos parâmetros ruminais e da produção de metano, o de parcelas subdivididas. O consumo foi influenciado pelo uso de monensina na dieta, mas não diferiu entre os aditivos. As digestibilidades da matéria seca e dos nutrientes não foram influenciadas pelo fornecimento dos aditivos. A relação acetato:propionato nos animais alimentados com a dieta com monensina foi menor que naqueles que receberam o complexo de leveduras e ácidos graxos poliinsaturados e aminoácidos, diminuindo a perda de energia na forma de metano. O pH e a concentração de nitrogênio amoniacal foram adequados para o crescimento bacteriano. A concentração de metano não é alterada pelo uso dos aditivos testados.The objective of this study was to evaluate the effect of monensin, yeast complex, unsaturated fatty acids and amino acids on dry matter and nutrient intake, total and partial digestibility and ruminal parameters of ruminal fermentation (pH, ammonia nitrogen concentration and short chain fatty acids), the protozoa population and methane production. Six castrated steers, body weight 530 ± 15 kg were used, receiving yeast complex, polyunsaturated fatty acids and amino acids (5 g/dia), monensin (5 g/dia), caulim (5g/dia, used as control), added to a diet consisting of Tifton 85 (Cynodon spp.) hay and concentrate at 80:20. A randomized complete block design was used to analyze and a split-plot design was used to analyze ruminal fermentation and methane production. The intakes were influenced by monensin in the diet, and no difference was observed among the additives. The dry matter and nutrients digestibilities, were not influenced by supplementing with additives. The acetate:propionate ratio in the animals fed the diet with monensin was smaller than in those that received the yeast complex and polyunsaturated fatty acids and amino acids, decreasing the energy loss in the form of methane. The pH and ammonia nitrogen concentration were adequate to microbial growth. The methane concentration was not altered with the use of the amino acids tested.

This article aims to proceed a more sociological than literary reading of some aspects of nationalism in Oswald de Andrade, focusing predominantly the Manifesto da Poesia Pau-Brasiland the Manifesto Antropófago. Departing from the perspective of the relationship between literary field and political field, according to Pierre Bourdie's formulations, we try to signalthe conditions, literarily translated, that acted upon Oswald de Andrade's vision of the Brazilian social world.

The aim of this study was to evaluate the quality of prenatal care offered in 12 Basic Health Units (BHU) in the city of Sao Paulo, Brazil, through a review of medical and nurse charts, before and after the municipalization of the public health system. The indicator used considered excellence in care as: starting prenatal care in the first quarter of pregnancy; at least six medical visits; at least two results of blood screening for syphilis and one for HIV; returning to BHU up to 42 days after delivery. This indicator was not present in any care delivered in 2000, and only 7.7% of the care delivered in 2004 obtained it (1.1% to 30% of the care per unit assessed). Although there was an evident improvement in care during the period, the low proportion of excellent prenatal care shows an urgent need to improve this care in the BHU of São Paulo city.El objetivo de este estudio fue evaluar la calidad de la asistencia prenatal ofrecida en doce Unidades Básicas de Salud (UBS) del municipio de San Pablo a través de la revisión de los registros médicos y de enfermería antes y después de la municipalización del sistema de salud. Fue utilizado un indicador que consideraba como atención de excelencia aquella con: inicio del acompañamiento prenatal en el primer trimestre de la gestación; con un mínimo de seis consultas; registro de por lo menos dos resultados de exámenes serológicos para sífilis y una prueba para el VIH; retorno a la UBS hasta 42 días después del parto. Ese indicador no fue obtenido en ninguna atención realizada en el 2000 y apenas en 7,7% de las atenciones en el 2004 (1,1% a 30% de las atenciones por unidad evaluada). A pesar de que con evidente mejoría de la atención en el período, la baja proporción de atención prenatal de excelencia, revela una urgente necesidad de mejorar esa asistencia en las UBS en el Municipio de San Pablo.O objetivo deste estudo foi avaliar a qualidade da assistência pré-natal oferecida em doze Unidades Básicas de Saúde (UBS) do município de São Paulo, através da revisão dos prontuários médicos e de enfermagem antes e após a municipalização do sistema de saúde. Foi utilizado um indicador que considerava como atendimento de excelência aquele com início do acompanhamento pré-natal no primeiro trimestre da gestação, no mínimo seis consultas, registro de pelo menos dois resultados de exames sorológicos para sífilis e um teste para o HIV, retorno à UBS até 42 dias pós-parto. Esse indicador não foi obtido em nenhum atendimento realizado em 2000 e apenas em 7,7% dos atendimentos em 2004 (1,1 a 30% dos atendimentos por unidade avaliada). Embora com evidente melhora do atendimento no período, a baixa proporção de atendimento pré-natal de excelência revela urgente necessidade de melhorar essa assistência nas UBS no Município de São Paulo.

Foi proposta desta pesquisa obter subsídios para iniciar ou manter manobras de reanimação cardiopulmonar (RCP) especificamente em vítimas de trauma. A duração da parada e reanimação cardiopulmonar de sobreviventes foi descrita, assim como, o desempenho cerebral e mortalidade dessas vítimas 24, 48 e 72 horas após tais eventos terem ocorrido. Com os resultados dessa caracterização estudou-se a relação entre tempo de parada e reanimação cardiorrespiratória, e, mortalidade. Os dados foram obtidos em plantões no Pronto Socorro do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Grande parte das vítimas (93,4%) apresentaram trauma grave e a principal "causa mortis" foi trauma crânio-encefálico. A sobrevivência ao período de 72 horas foi de 10%. A avaliação de 72 horas, das vítimas sobreviventes a parada cardiorrespiratória (PCR) de causa traumática mostrou mau desempenho cerebral dessas vítimas no período. A sobrevida após o primeiro episódio de PCR relacionou-se mais consistentemente com o tempo de PCR das vítimas de trauma do que o tempo de RCP. O tempo de PCR The proposal of this research was to obtain parameters to start or maintain cardiopulmonary resuscitation (CPR) in victims of trauma. The duration of the cardiac arrest and the CPR of the survivors was described, as well as the cerebral performance and the mortality of these victims 24, 48 and 72 hours after these events had happened. With the results of this caracterization the relation between duration of cardiac arrest time, CPR and mortality were described. Data for this report were coleted in Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo emergency departament. A big amount of the victims (93, 4%) presents severe trauma and main cause of death was brain injury. Survival at 72 hours after CPR was 10%. The assessment, during the 72 hour period, of the survivors from cardiac arrest of traumatic cause has shown bad cerebral performance of those victims in that period of time. The survivor after the first episod of CPR was strongly related to cardiac arrest time when compared with CPR time. The time of cardiac arrest ¡Ü 4 minuts and CPR ¡Ü 20 minuts was related to survival more than 72 hours.

Los caracteres tegumentarios raramente han sido incluidos en Ornitología Sistemática, a pesar de que la mayoría de los caracteres utilizados para diferenciar especies son de plumaje, ranfoteca (cubierta córnea del pico y narinas) y podoteca (escamas de las patas), y de que muchos de estos caracteres contribuyen a las diagnosis tradicionales de los grandes grupos de Órdenes. Varios estudios recientes han utilizado caracteres tegumentarios en un contexto cladístico, en particular, una filogenia comprensiva de perdices que incluyó a los 9 géneros, todas las 47 especies actualmente reconocidas, y algunas de las subespecies claramente definidas. En este trabajo re-evaluamos la posición en dicha filogenia de la especie oscura Tinamus osgoodi. En análisis previos, esta perdiz selvática había sido recuperada junto a las especies de Crypturellus, que también tienen plumaje de colores oscuros. Todas estas especies son posiblemente melánicas, o presentan un patrón de coloración de plumaje que afecta a muchos pterylae a la vez. Discutimos la dependencia de algunos caracteres del plumaje de perdices, y re-analizamos la matriz de datos tegumentaria recodificando dichos caracteres en las especies oscuras. Utilizando pesos implicados para la reconstrucción filogenética, recuperamos la mayoría de los agrupamientos esperados, incluyendo a Tinamus osgoodi como un miembro de su género. Es interesante destacar que la posición de dicha especie no influyó en las especies oscuras de Crypturellus, las cuales podrían haber sido afectadas por el mismo esquema de codificación, y sin embargo, se agruparon junto a sus congéneres, indicando que la interacción con otros caracteres jugó un papel crucial en la recuperación de estos taxa en sus respectivos géneros. Finalmente, comentamos sobre el uso de caracteres tegumentarios y la incidencia de su codificación en Ornitología Sistemática.

Sin resumen

OBJETIVO: Avaliar a frequência da mutação V600E do gene BRAF em pacientes com mais de 65 anos de idade submetidos à tireoidectomia, correlacionando sua presença ou ausência com as diferentes lesões histológicas, com as variantes e com fatores prognósticos do carcinoma papilífero. MÉTODOS: Foram avaliados 85 pacientes com mais de 65 anos de idade submetidos à tireoidectomia, analisando a mutação BRAF V600E através de reação de PCR-RT realizada após a extração do DNA dos blocos de parafina. RESULTADOS: Detectou-se ausência ou presença da mutação BRAF V600E em 47 pacientes (55,3%). Entre os 17 carcinomas papilíferos estudados, sete apresentavam a mutação (41,2%). Demonstrou-se associação estatística entre a presença desta mutação e a variante clássica do carcinoma papilífero, além de tendência de associação com o extravasamento tireoideano. CONCLUSÃO: A mutação BRAF nos pacientes idosos também é exclusiva do carcinoma papilífero e tem frequência expressiva. Além disso, está relacionada à variante clássica e, possivelmente, ao extravasamento tireoideano.

The use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation. Protease inhibitors are compounds that can decrease activity of an enzyme. They are found in plants, especially in Fabaceae, Poaceae, and Solanaceae families, and show satisfactory use to treat diseases due to their regulatory activities and selective proteolytic degradation of target substrates. This study aimed to obtain protease inhibitors in the seeds of Punica granatum, due its use in traditional medicine. The alcohol-acid solution was used to extract and isolate the protease inhibitors in P. granatum seeds and Glycine max grains. The extract of P. granatum seeds showed similar concentration of protease inhibitors when compared to G. max. A 14 kDa band was detected by electrophoresis on polyacrylamide gel, which was characterized by high-performance liquid chromatography as protease inhibitors. The extract of P. granatum seeds showed a potent trypsin inhibitor activity (EC50 18.2 ng mL-1). This study showed for the first time the extraction, purification, and identification of protease inhibitors in Punica granatum seeds.

RESUMO Objetivo: identificar, na literatura, artigos que avaliaram a efetividade ou eficácia de intervenções não farmacológicas para melhorar a qualidade de vida de pessoas com insuficiência cardíaca. Método: revisão integrativa de literatura realizada nas bases de dados Lilacs, MedLine e SciELO, incluindo ensaios clínicos randomizados ou não randomizados e estudos quase-experimentais publicados entre 2003 e 2014, em português, inglês e espanhol. Resultados: foram incluídos 23 estudos. As categorias de intervenções não farmacológicas que melhoraram a qualidade de vida de pessoas com insuficiência cardíaca foram: Monitoramento remoto da saúde, Orientação sobre práticas de saúde, Acompanhamento de atividade física e Práticas de Medicina Tradicional Chinesa. Conclusão: estes resultados podem direcionar a seleção de intervenções a serem implementadas por profissionais de saúde que cuidam de pessoas com insuficiência cardíaca. Futuras revisões sistemáticas com metanálise são necessárias para identificar as intervenções mais eficazes para melhorar a qualidade de vida desses indivíduos.

ABSTRACT Objective: to analyze the trend of hospitalizations of adolescents due to mental and behavioral disorders in Paraná, from 1998 to 2015. Method: ecological study of time series. Data were analyzed by means of segmented linear regression modeling for time series, estimated for each of the four health macro-regions. Results: the East macro-region showed a greater trend to increase hospitalizations from January 1998 to November 2003 (β1=0.006, p