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1. [Synthesis and secretion of the surface antigen from hepatitis B virus in animal cell cultures].

Author

De Ioannes AE, Yudelevich A, and Venegas A

Subjects
Animals, Cricetinae, Female, Hepatitis B Surface Antigens genetics, Hepatitis B Surface Antigens isolation & purification, Mice, Mice, Inbred BALB C, Ovary cytology, Transfection, Genetic Engineering, Hepatitis B Surface Antigens biosynthesis, Plasmids genetics
Abstract

Stable mammalian cell lines synthesizing and secreting Hepatitis B surface particles have been obtained through genetic engineering techniques. These particles show by electron microscopy a size of 22 nm, they are structurally and immunochemically similar to the particles present in the plasma from chronic hepatitis B patients. Therefore these particles are an excellent source for the preparation of a vaccine against the virus.

Published
1988

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