1. [8-oxo-7,8-dihydro-2'-deoxyguanosine as a marker of DNA oxidative stress in individuals with combined familiar hyperlipidemia].
- Author
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Ferri J, Martínez-Hervás S, Espinosa O, Fandos M, Pedro T, Real JT, Chaves FJ, Cerdá C, Sáez G, and Ascaso JF
- Subjects
- 8-Hydroxy-2'-Deoxyguanosine, Adult, Biomarkers blood, Case-Control Studies, Deoxyguanosine blood, Female, Humans, Hyperlipidemia, Familial Combined metabolism, Male, Middle Aged, DNA metabolism, Deoxyguanosine analogs & derivatives, Hyperlipidemia, Familial Combined blood, Hyperlipidemia, Familial Combined genetics, Oxidative Stress
- Abstract
Background and Objective: To compare 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) value as an indicator of oxidative stress situation between healthy and familial combined hyperlipidemic (FCH) subjects as a mixed dislipidemia with insulin resistance model and early coronary heart disease, and to study its relationship with clinical-biologic parameters of insulin resistance., Subjects and Method: 40 non-related FCH patients (15 women) and 20 normolipidemic and nondiabetic healthy subjects (8 women) were studied. Clinical, anthropometric and biochemical parameters (lipidic profile, glucemia, insulinemia and 8-oxo-dG) were measured in fasting state in all., Results: Both groups had similar age, body mass index blood pressure and waist perimeter values. Insulin and 8-oxo-dG values were significantly higher in FHC subjects. These differences were maintained after correcting by waist perimeter. 8-oxo-dG correlated positively with insulin and trygliceride; and negatively with high density lipoprotein cholesterol in FCH subjects., Conclusions: Insulin values are independently correlated with oxidative stress degree measured as 8-oxo-dG.
- Published
- 2008
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