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Background and Objective: Pulmonary thromboembolism (PTE) is a very common condition with high mortality. Although some scales include heart failure (HF) as a risk factor of PTE, none of them have assessed the contribution of the different kinds of HF, i. e. with reduced or preserved left ventricular ejection fraction (LVEF) to the in-hospital outcome of patients admitted with PTE., Patients and Method: A retrospective study assessing a cohort of patients consecutively admitted to hospital with a PTE from 2012-2014. Baseline epidemiological characteristics, treatment during admission and prognostic variables during hospitalization were analyzed. Primary endpoint was defined as hospital mortality for any cause., Results: A total of 442 patients with PTE were included (88 with prior HF). Patients with a history of HF were older, more frequently had hypertension, diabetes mellitus, chronic kidney or pulmonary disease, cancer, and coronary artery disease, and showed less LVEF (P<.001). Hospital mortality was significantly higher in patients with prior HF (21.6 vs. 6.8%, P<.001). Multivariate analysis found that HF with reduced LVEF but not HF with preserved LVEF resulted as an independent risk factor (respectively OR 5.54; 95% CI 2.12-14.51 and OR 129; 95% CI 0.72-4.44)., Conclusions: Patients with prior HF admitted to hospital with PTE should be considered a high-risk population, since they present high in-hospital mortality. In our cohort, patients with prior HF and reduced LVEF presented a poorer prognosis than those with preserved LVEF., (Copyright © 2016 Elsevier España, S.L.U. All rights reserved.)

Objective: Detection of high-risk human papillomavirus types (HPV) infection is an important tool in the screening of cervical cancer and triage of cytological abnormalities. The different techniques for detection of this cancer need to be contrasted and validated for use in population screening., Material and Methods: Cervical cell samples were collected from 166 women attending a dermatology clinic in Oviedo (Spain). We evaluated the performance of three different assays for VPH detection. The methods utilized were 1) In-house PCR-EIA using LI consensus primers MY09/ MY11, 2) A PCR-reverse line blot hybridization (PCR-LBH) that uses LI consensus PGMY primers. 3) Hybrid Capture 2. All assays were performed blinded. The kappa statistic was used to test for global agreement between assay pairs., Results: HPV DNA was detected in 24,7%, 25,3% and 29,5% of the women, respective to the assay. The overall agreement between the in-house PCR, PCR-LBH and HC2 was (73.5%) with all kappa values between assay pairs exceeding 0.56 (p<0.001)., Conclusion: The three HPV assays were equally accurate in estimating high-risk HPV prevalence and HPV-related lesions. The method for HPV detection must be decided depending on the goals of the search (screening, follow-up or molecular studies).