1. [Simultaneous presence of antibodies against the glomerular basement membrane and anti-myeloperoxidase antibodies in 2 patients with rapidly progressive glomerulonephritis].
- Author
-
Díaz Rodríguez C, Costero O, Torre A, De Alvaro F, Gil F, Picazo ML, and Martínez-Ara J
- Subjects
- Aged, Antibodies, Antineutrophil Cytoplasmic immunology, Autoimmune Diseases complications, Basement Membrane immunology, Biopsy adverse effects, Combined Modality Therapy, Cyclophosphamide therapeutic use, Disease Progression, Fatal Outcome, Female, Glomerulonephritis complications, Glomerulonephritis pathology, Hemorrhage etiology, Humans, Hypertrophy, Left Ventricular complications, Immune Complex Diseases immunology, Immune Complex Diseases pathology, Immunoglobulin G analysis, Immunosuppressive Agents therapeutic use, Kidney Glomerulus pathology, Kidney Glomerulus ultrastructure, Methylprednisolone therapeutic use, Middle Aged, Plasmapheresis, Prognosis, Renal Dialysis, Retroperitoneal Space, Autoantibodies immunology, Autoantigens immunology, Autoimmune Diseases immunology, Glomerulonephritis immunology, Kidney Glomerulus immunology, Peroxidase immunology
- Abstract
We report two patients with rapidly progressive glomerulonephritis without alveolar hemorrhage. Renal biopsy showed extracapillary glomerulonephritis with linear deposits of immunoglobulin G. Serologically anti-glomerular basement membrane antibodies (Ac AMBG) and ANCA anti-myeloperoxidase were present. All patients were treated with steroids, cyclophosphamide and plasma exchange. One patient needed dialysis, and other one died from a renal biopsy complication. We discuss the epidemiologic, pathogenic and prognostic aspects of this association.
- Published
- 2002