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11 results on '"Intravenous administration"'

1. USE OF SAFETY BARRIERS IN THE PREPARATION OF VASOACTIVE DRUGS AND SEDATIVES/ANALGESICS IN PEDIATRIC INTENSIVE CARE

Author

Carla Susana Martinez Julca, Patrícia Kuerten Rocha, Andreia Tomazoni, Bruna Figueiredo Manzo, Sabrina de Souza, and Jane Cristina Anders

Subjects
Patient safety, Medication errors, Intravenous administration, Medication systems, hospital, Pediatric nursing, Nursing, RT1-120, Medicine (General), R5-920, Public aspects of medicine, RA1-1270
Abstract

Objective: to analyze the use of safety barriers in the preparation of vasoactive drugs and sedatives/analgesics. Method: quantitative study, with 204 observations during the preparation of medications in a Pediatric Intensive Care Unit in the Pediatric Hospital of the State of Santa Catarina, between March 2016 and May 2017. The barriers analyzed were: type of prescription; transcription of the medication, identification of the patient and data on the label; label attachment; double checking; preparation of continuous infusions; and interruptions. The data were analyzed using descriptive statistics. Results:the safety barriers were related to written prescription (93.6%); transcription of the medication on the label (87.7%); patient identification on the label only by the first name (96%); data relating to the medication on the label failing to include the transcription of the route of administration (99.4%); double checking (34.6%); and interruptions during the preparation (52.9%). Conclusion: this study alerts the area to the need to implement barriers so as to promote safe clinical practice.

Published
2018
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2. Prevalencia de prescripción: indicación de protectores gástricos en pacientes hospitalizados A survey of gastroprotective drugs: prescription-indication in hospitalized patients

Author

Vicente Lorenzo Zúñiga, Belén Cabana González, and Álvaro Hermida Ameijeiras

Subjects
Fármacos gastroprotectores, Utilización racional de medicamentos, Administración intravenosa, Omeprazol, Pantoprazol, Inhibidores de la bomba de protones, Prescripción, Indicación, Gastroprotective drugs, Rational drug use, Intravenous administration, Omeprazole, Pantoprazole, Proton pump inhibitors, Prescription, Indication, Public aspects of medicine, RA1-1270
Abstract

La prescripción de fármacos antiulcerosos en medio hospitalario, y su influencia posterior en atención primaria, se incrementó en los últimos años y con ello el gasto farmacéutico. El objetivo del presente estudio es analizar la prevalencia de prescripción de antiulcerosos en nuestro centro hospitalario y la adecuación a las indicaciones establecidas. Se realizó un estudio observacional de prescripción-indicación con 2 cortes transversales separados en 6 meses para evitar sesgos de selección. Se constata el uso elevado de gastroprotectores, principalmente inhibidores de bomba de protones, sobre todo en profilaxis de gastropatía por antiinflamatorios no esteroideos (AINE) (17,1%), con una tasa de prescripciones incorrectas del 77,6% a pesar de la existencia de un protocolo específico elaborado por el comité de farmacia y terapéutica de nuestro centro. Destaca el número elevado de prescripciones en pacientes con corticoterapia sin asociación con AINE (25,7%). Se requieren nuevas herramientas que impliquen al facultativo y a los gestores clínicos en el uso racional de medicamentos.Prescription rates of anti-ulcer drugs in hospitals and their spill-over to general practice have risen over the last few years, increasing pharmaceutical expenses. The aim of this study was to analyze gastroprotective drug prescription habits in our hospital by assessing both prevalence and adherence to approved indications. An observational study of prescription-indication was performed with 2 cross sections separated by 6 months to avoid selection bias. We found overprescription of gastroprotective drugs, mainly proton pump inhibitors for the prevention of non-steroidal antiinflammatory drug-induced ulcer (17.1%). Overall, 77.6% of prescriptions had no acceptable indication, despite the availability of a specific protocol produced by the Pharmacy and Therapeutics Committee in our center. There was a high prevalence of prescriptions for non-approved indications such as prophylaxis in patients administered corticosteroids without non-ste.

Published
2007

3. Cross-sectional study of potential incompatibility of intravenous medications in a Neonatal Intensive Care Unit in Indonesia.

Author

Mahendra AD, Hanifah S, and Sari CP

Subjects
Infant, Newborn, Humans, Cross-Sectional Studies, Prospective Studies, Indonesia, Amikacin, Pharmaceutical Preparations, Drug Combinations, Ampicillin, Infusions, Intravenous, Intensive Care Units, Neonatal, Sulbactam
Abstract

Objective: The purpose of this study is to determine the most common incompatible and unknown compatibility drug combinations and determine the compatibility of each pair of drugs used in hospitals based on reference books and journals., Methods: This is a prospective cross-sectional study. All babies who were admitted to the Neonatal Intensive Care Units from May First to July 31 st 2021 were sample of the study. Patients who did not receive at least two drugs coadministrated concurrently and who stayed less than 24 hours were excluded. Only drug-drug combinations were considered and the other non-drug administrations (electrolyte solutions, parenteral nutritions, and blood products) were excluded. Compatibility data were obtained from literature and online search engines (micromedex NeoFax Essentials 2020, UCL Hospitals Injectable Medicines Administration Guide: Pharmacy Department, 3rd Edition, Trissel Handbook on injectable drugs 15th edition, and published journals)., Results: The most commonly prescribed drug combinations were ampicillin-gentamicin (31.72%), amikacin-ampicillin sulbactam (9.05%), amikacin-ampicillin sulbactam-aminophylline (3.08%). The most common drug incompatible combination was ampicillin-gentamicin (31.71%), for the most drug combinations whose compatibility unknown were amikacin-ampicillin sulbactam (9.05%)., Conclusions: The high prevalence of incompatible drugs and unknown compatibility was identified, so checking its compatibility can be carried out through a two-dimensional chart to minimize the incidence of incompatibilities., (Copyright © 2022 Sociedad Española de Farmacia Hospitalaria (S.E.F.H). Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2023
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4. Adherence and potential adverse events prevented during the administration of intravenous medications using Smart infusion pump in four intensive care units in Colombia

Author

Ismery Yaneth Robles Méndez, Ruby Emilse Dueñas Badillo, Diego Rincón Castillo, Luis Alberto López-Romero, Diana Isabel Cáceres Rivera, Jennifer Vanesa Acosta-Barón, and Gloria Isabel Parra de Rey

Subjects
infusion pumps, Medication errors, intravenous administration, efectos adversos, adverse effects, administración intravenosa, bombas de infusión, safety management, administración de la seguridad, Errores de medicación
Abstract

Resumen Introducción: Las bombas de infusión inteligentes, constituyen una herramienta útil para la administración segura de medicamentos endovenosos dado que permiten prevenir potenciales eventos adversos. Objetivo: Evaluar la adherencia y los potenciales eventos adversos prevenidos, durante la administración de medicamentos endovenosos empleando bombas de infusión inteligentes. Metodología: Estudio observacional, realizado en cuatro unidades de cuidados intensivos usando datos del software Hospira MedNetTM. Un análisis descriptivo fue llevado a cabo junto con un análisis bivariado empleando una prueba U de Mann-Whitney, una prueba de Kruskal-Wallis y un test de Bonferroni para evaluar la adherencia y los potenciales eventos adversos prevenidos por año y servicio. Resultados: La adherencia fue del 74,0%, se presentaron 78.299 alertas de seguridad y se previnieron 4,54% (n=16.288) potenciales eventos adversos. Se encontraron diferencias entre el primer y segundo año en la adherencia [Mediana: 69,15 (Q1:64,2-Q3:75,5) Vs Mediana: 84,2(Q1:72,15-Q3:89,05), p

Published
2019

5. Incompatibilidad de medicamentos intravenosos: revisión estructurada

Author

Madrigal-Cadavid, Juliana and Amariles, Pedro

Subjects
Drug Incompatibility, Infusiones intravenosas, Intravenous infusions, Administración intravenosa, Incompatibilidad de medicamentos, Intravenous administration
Abstract

Resumen Introducción: Las incompatibilidades físicas o químicas presentadas entre las mezclas de medicamentos de uso intravenosos pueden comprometer la eficacia y seguridad del tratamiento y del paciente. La disponibilidad de la información relacionada con este aspecto es limitada o fraccionada, lo que restringe su uso. El objetivo del presente trabajo fue sistematizar la información disponible en las bases de datos sobre compatibilidad/incompatibilidad entre medicamentos intravenosos, que favorezca los procesos de prescripción, preparación y administración. Métodos: Revisión estructurada de incompatibilidades de medicamentos intravenosos en PubMed/MedLine utilizando los términos MeSH: Drug Incompatibility, Administration Intravenous, and Infusions Intravenous. Se buscaron artículos en inglés o español, con acceso a texto completo hasta febrero 29 del 2016. Se identificaron 121 artículos, de los cuales se seleccionaron 58; además se incluyeron 18 manuscritos de las referencias considerados como importantes. Resultados: Se estructuró un cuadro sobre compatibilidad/incompatibilidad de 100 medicamentos intravenosos, el tiempo de estabilidad, condiciones de almacenamiento, tipo de compatibilidad/incompatibilidad presentada y tipo de administración recomendada. Conclusión: Se presenta información sobre compatibilidad / incompatibilidad de medicamentos, la cual podría favorecer los procesos de prescripción, preparación y administración por el personal asistencial y con ello contribuir a la efectividad y seguridad de estos medicamentos. Abstract Introduction: The physical or chemical incompatibilities between mixtures of intravenous drugs may compromise the efficacy and safety of treatment and the patient. The availability of information related to this aspect is limited or fractionated, which restricts its use; in this context. The objective of the present study was to compile in a table the available information in the databases on the compatibility/incompatibility between intravenous drugs, which favors the processes of prescription, preparation and administration of these products. Methods: We completed a structured review of incompatibilities of intravenous drugs in PubMed/Medline using the MeSH terms: Drug Incompatibility, Administration Intravenous, and Infusions Intravenous, we collected articles in English or Spanish, with access to full text until February 29, 2016. We identified 121 articles, from which we selected 58; additionally we included 18 manuscripts of the references considered as important. Results: With the information obtained was structured a table on compatibility/incompatibility of 100 intravenous drugs, the time of stability, conditions of storage, type of compatibility/incompatibility presented and the type of management recommended. Conclusion: We arranged information on compatibility/incompatibility of drugs, which may improve the processes of prescription, preparation and administration by the health care professionals, so it could contribute to the effectiveness and safety of these drugs.

Published
2017

6. Seguridad en la administración intravenosa de medicamentos mediante bombas de infusión inteligentes

Author

Gómez-Baraza, C., Agustín-Fernández, M.ª J., Palomo-Jiménez, P. I., Real-Campaña, J. M., and Abad-Sazatornil, R.

Subjects
Bombas inteligentes, Medication errors, Administración intravenosa, Errores de medicación, Smart pumps, Intravenous administration
Abstract

Objetivo: Analizar el papel de las bombas de infusión inteligentes en la reducción de errores relacionados con la administración de medicación intravenosa. Método: Estudio observacional, retrospectivo que analiza la implementación de un sistema de bombas inteligentes de infusión intravenosa (Hospira MedNetTM) y el papel de este sistema de seguridad en la detección de errores en la fase de administración de fármacos, sueros y sangre. Se incluyeron infusiones administradas en los hospitales de día de hematología, oncología, reumatología y oncopediatría. Se analizó la adherencia al sistema de seguridad, el número de errores de programación detectados, los fármacos comúnmente implicados en estos errores y las acciones de mejora. Resultados: Durante el periodo de estudio se implementaron 120 bombas inteligentes y se recogieron los datos de 70.028 infusiones. La adherencia al programa de seguridad fue del 62,30% en hematología (6.887 infusiones), del 60,30% en oncología (28.127 infusiones), del 46,50% en reumatología (1.950 infusiones) y del 1,8% en oncopediatría (139 infusiones). Se notificaron 3481 alertas por programación de las bombas fuera de los límites establecidos: 2716 de límite relativo y 765 de límite absoluto. En 807 infusiones (2,17%), se evitaron errores que podrían haber tenido consecuencias para los pacientes. Gracias a estos hallazgos, se implementaron una serie de estrategias con objeto de minimizar dichos errores en el futuro. Conclusiones: El sistema Hospira MedNetTM intercepta desviaciones con respecto a los protocolos establecidos en la infusión intravenosa, evitando potenciales efectos adversos a pacientes. También permite establecer medidas correctoras e implementar estrategias de mejora. Objective: To analyze the role of smart infusion pumps in reducing errors related with the administration of intravenous medications. Method: Retrospective, observational study analyzing the implementation of a system with smart intravenous infusion pumps (Hospira MedNetTM) and the role of the safety system for the detection of errors during the administration of drugs, sera, and blood. We included infusions administered at the day-care hospitals of hematology, oncology, rheumatology, and oncopediatrics. We analyzed adherence to the safety system, the number of programming errors detected, the commonly implicated drugs in these errors, and improvement actions Results: During the study period, 120 smart pumps were implemented and data on 70,028 infusions were gathered. The rate of adherence to the safety program was 62.30% in hematology (6,887 infusions), 60,30% in oncology (28,127 infusions), 46,50% in rheumatology (1,950 infusions) and 1.8% in oncopediatrics (139 infusions). 3,481 out of the established limits programming alerts were generated by the pumps: 2,716 of relative limit and 765 of absolute limit. En 807 infusions (2.17%), errors that could have had consequences for the patients could be prevented. These findings allowed implementing a series of strategies aimed at minimizing these errors in the future. Conclusions: The Hospira MedNetTM system detects deviations from the established protocols of intravenous infusion, preventing in this way potential adverse events for the patients. It also allows establishing correction measures and implementing the improvement strategies.

Published
2014

7. Which route of administration of acid tranexamic, intravenous or intra-articular, is more effective in the control of post-surgical bleeding after a total hip arthroplasty? A prospective, controlled and randomized study.

Author

Gómez Barbero P, Gómez Aparicio MS, Blas Dobón JA, Pelayo de Tomás JM, Morales Suárez-Varela M, and Rodrigo Pérez JL

Subjects
Administration, Intravenous, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Injections, Intra-Articular, Male, Middle Aged, Prospective Studies, Young Adult, Antifibrinolytic Agents administration & dosage, Arthroplasty, Replacement, Hip, Postoperative Hemorrhage prevention & control, Tranexamic Acid administration & dosage
Abstract

Introduction: One of the most frequent complications after a total hip arthroplasty (THA) is bleeding, intravenous tranexamic acid (TXA) is used to reduce it. We considered it necessary to carry out a study to clarify which administration route is superior., Material and Method: Prospective, controlled and randomized study in 2 arms carried out between February 2017 and February 2018. 15mg/kg of intravenous TXA were administered in group-A and 2gr of intra-articular TXA in group-B. The values of haemoglobin and haematocrit were evaluated at 24h-72h, blood loss volume, drained blood volume, transfusions and complications., Results: 78 patients were included, 31 with intravenous treatment and 47 with intra-articular. The decrease of haemoglobin in the intravenous group was 3.15±1.64g/dl in 24h and 3.75±1.56g/dl in 72h, the haematocrit decreased by 10.4±4.17% in 24h and 11.85±4.15% in 72h. In the intra-articular group there was a haemoglobin fall of 3.03±1.30g/dl in 24h and 3.22±1.2g/dl in 72h and the haematocrit fell by 10.66±3.6% and 12,11±3.29% in 24 and 72h (P>.05). The mean drainage in 24h was 195.80ml in group-A versus 253.93ml in group-B (P>.05) and in 48h it was 225.33ml in group-A and 328.19ml in group-B (P=.009). The intravenous group lost an average of 1,505ml of blood compared to the 11,280ml of the intra-articular group. In 5.1% of the cases, transfusions were necessary. We had no secondary complications., Conclusions: The different routes of administration of TXA in THA have a similar effect in the reduction of postoperative bleeding. There was no evidence of an increase in complications., (Publicado por Elsevier España, S.L.U.)

Published
2019
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8. Prevalencia de prescripción: indicación de protectores gástricos en pacientes hospitalizados

Author

Hermida Ameijeiras, Álvaro, Cabana González, Belén, and Vicente Lorenzo-Zúñiga

Subjects
Proton pump inhibitors, Rational drug use, Inhibidores de la bomba de protones, Omeprazol, Utilización racional de medicamentos, Prescription, Intravenous administration, Indication, Fármacos gastroprotectores, Prescripción, Gastroprotective drugs, Administración intravenosa, Pantoprazole, Omeprazole, Pantoprazol, Indicación
Abstract

La prescripción de fármacos antiulcerosos en medio hospitalario, y su influencia posterior en atención primaria, se incrementó en los últimos años y con ello el gasto farmacéutico. El objetivo del presente estudio es analizar la prevalencia de prescripción de antiulcerosos en nuestro centro hospitalario y la adecuación a las indicaciones establecidas. Se realizó un estudio observacional de prescripción-indicación con 2 cortes transversales separados en 6 meses para evitar sesgos de selección. Se constata el uso elevado de gastroprotectores, principalmente inhibidores de bomba de protones, sobre todo en profilaxis de gastropatía por antiinflamatorios no esteroideos (AINE) (17,1%), con una tasa de prescripciones incorrectas del 77,6% a pesar de la existencia de un protocolo específico elaborado por el comité de farmacia y terapéutica de nuestro centro. Destaca el número elevado de prescripciones en pacientes con corticoterapia sin asociación con AINE (25,7%). Se requieren nuevas herramientas que impliquen al facultativo y a los gestores clínicos en el uso racional de medicamentos. Prescription rates of anti-ulcer drugs in hospitals and their spill-over to general practice have risen over the last few years, increasing pharmaceutical expenses. The aim of this study was to analyze gastroprotective drug prescription habits in our hospital by assessing both prevalence and adherence to approved indications. An observational study of prescription-indication was performed with 2 cross sections separated by 6 months to avoid selection bias. We found overprescription of gastroprotective drugs, mainly proton pump inhibitors for the prevention of non-steroidal antiinflammatory drug-induced ulcer (17.1%). Overall, 77.6% of prescriptions had no acceptable indication, despite the availability of a specific protocol produced by the Pharmacy and Therapeutics Committee in our center. There was a high prevalence of prescriptions for non-approved indications such as prophylaxis in patients administered corticosteroids without non-ste.

Published
2007

9. Prevalencia de prescripción-indicación de protectores gástricos en pacientes hospitalizados

Author

Vicente Lorenzo Zúñiga, Álvaro Hermida Ameijeiras, Belén Cabana González, and Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina

Subjects
Drug, medicine.medical_specialty, Proton pump inhibitors, media_common.quotation_subject, Rational drug use, MEDLINE, Prescription, Intravenous administration, medicine, In patient, Medical prescription, Pharmacy and Therapeutics, Administración intravenosa, Pantoprazole, media_common, Indicación, Selection bias, business.industry, Public Health, Environmental and Occupational Health, Inhibidores de la bomba de protones, Ome-prazol, Utilización racional de medicamentos, Indication, Fármacos gastroprotectores, Prescripción, Gastroprotective drugs, Emergency medicine, Observational study, business, Omeprazole, medicine.drug, Pantoprazol
Abstract

La prescripción de fármacos antiulcerosos en medio hospitalario, y su influencia posterior en atención primaria, se incrementó en los últimos años y con ello el gasto farmacéutico. El objetivo del presente estudio es analizar la prevalencia de prescripción de antiulcerosos en nuestro centro hospitalario y la adecuación a las indicaciones establecidas. Se realizó un estudio observacional de prescripción-indicación con 2 cortes transversales separados en 6 meses para evitar sesgos de selección. Se constata el uso elevado de gastroprotectores, principalmente inhibidores de bomba de protones, sobre todo en profilaxis de gastropatía por antiinflamatorios no esteroideos (AINE) (17,1%), con una tasa de prescripciones incorrectas del 77,6% a pesar de la existencia de un protocolo específico elaborado por el comité de farmacia y terapéutica de nuestro centro. Destaca el número elevado de prescripciones en pacientes con corticoterapia sin asociación con AINE (25,7%). Se requieren nuevas herramientas que impliquen al facultativo y a los gestores clínicos en el uso racional de medicamentos Prescription rates of antiulcer drugs in hospitals and their spill-over to general practice have risen over the last few years, increasing pharmaceutical expenses. The aim of this study was to analyze gastroprotective drug prescription habits in our hospital by assessing both prevalence and adherence to approved indications. An observational study of prescription-indication was performed with 2 cross sections separated by 6 months to avoid selection bias. We found overprescription of gastroprotective drugs, mainly proton pump inhibitors for the prevention of non-steroidal antiinflammatory drug-induced ulcer (17.1%). Overall, 77.6% of prescriptions had no acceptable indication, despite the availability of a specific protocol produced by the Pharmacy and Therapeutics Committee in our center. There was a high prevalence of prescriptions for non-approved indications such as prophylaxis in patients administered cor-ticosteroids without non-steroidal anti-inflammatory agents (25.7%). New programs to train clinicians and clinical mana-gers in rational drug use are required SI

Published
2007

10. In(compatibility) of intravenous drugs in critical units: adult cohort

Author

Julia Helena Garcia, Jeiel Carlos Lamonica Crespo, Alina Yukie Handa, Kátia Grillo Padilha, and Silvia Regina Secoli

Subjects
Intravenous Administration, Incompatibility of Drugs, Intensive Care Units, Critical Care Nursing, Nursing Education, Nursing, RT1-120
Abstract

ABSTRACT Objectives: To analyze potential (in)compatibilities of intravenous drugs based on the scheduling prepared by the nursing team. Methods: historic cohort (retrospective) with 110 adults in critical units. Intravenous medications were identified concomitantly, whose pairs were analyzed for (in) compatibility using the screening system Trissel’s™ 2 Compatibility IV-Micromedex 2.0. Parametric and non-parametric statistic were used according to the nature of the variable. Results: 565 pairs of drugs were identified. Of these, 44.9% were compatible; and 8.8%, potentially incompatible. Most potentially incompatible pairs involved substances with alkaline pH such as phenytoin (32%) and sodium bicarbonate (8%) and weak acids such as midazolam (12%) and dobutamine (6%), which could result in precipitate formation. Conclusions: almost half of the mixtures simultaneously administrated was compatible, which indirectly reflects in the organized work between the nursing team and the clinical pharmaceutic in the discussions and decisions related to time scheduling.

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11. Safe intravenous administration in pediatrics: A 5-year Pediatric Intensive Care Unit experience with smart pumps.

Author

Manrique-Rodríguez S, Sánchez-Galindo AC, Fernández-Llamazares CM, Calvo-Calvo MM, Carrillo-Álvarez Á, and Sanjurjo-Sáez M

Subjects
Child, Child, Preschool, Female, Humans, Male, Medication Errors, Prospective Studies, Infusion Pumps, Infusions, Intravenous, Intensive Care Units, Pediatric
Abstract

Objectives: To estimate the impact of smart pump implementation in a pediatric intensive care unit in terms of number and type of administration errors intercepted., Design: Observational, prospective study carried out from January 2010 to March 2015 with syringe and great volumen infusion pumps available in the hospital., Setting: A tertiary level hospital pediatric intensive care unit., Participants: Infusions delivered with infusion pumps in all pediatric intensive care unit patients., Interventions: Design of a drug library with safety limits for all intravenous drugs prescribed., Main Variables: Users' compliance with drug library as well as number and type of errors prevented were analyzed., Results: Two hundred and eighty-three errors were intercepted during 62 months of study. A high risk drug was involved in 58% of prevented errors, such as adrenergic agonists and antagonists, sedatives, analgesics, neuromuscular blockers, opioids, potassium and insulin. Users' average compliance with the safety software was 84%., Conclusions: Smart pumps implementation has proven effective in intercepting high risk drugs programming errors. These results might be exportable to other critical care units, involving pediatric or adult patients. Interdisciplinary colaboration is key to succeed in this process., (Copyright © 2016 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.)

Published
2016
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