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Coumarin derivatives possess diverse biological activities, encompassing antibacterial, antifungal, anticancer, antidiabetic, anti-inflammatory, and antioxidant effects. This study concentrates on the synthesis of two new coumarins: the first derived from rhizomes of Luvunga scandens and the second from 7-(diethylamino)-4-methyl-2H-chromen-2-one via bromination facilitated by NBS (N-bromosuccinimide) reagent. Their antibacterial and anticancer properties were evaluated in vitro, alongside in silico docking targeting the chromen-2-one group. Bromination of compound 1 yielded novel compound 2, while compound 4 was efficiently synthesized from 7-(diethylamino)-4-methyl-2H-chromen-2-one (3) using NBS. Testing on lung, breast, and liver cancer cell lines indicated that compound 2 effectively inhibited Staphylococcus aureus and Bacillus cereus at concentrations of 13.20 and 6.6 µM, respectively. It also demonstrated significant inhibition against MCF-7 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of 50.37 ± 3.70 µM. Molecular docking revealed compound 2’s interaction with 2VF5 enzyme, elucidating its bacterial inhibition mechanism, with Gibbs energy and inhibition constant values of -7.42 kcal mol-1 and 3.62 µM, respectively. Additionally, compound 2 exhibited anticancer activity via alignment with topoisomerase 1 (3TOP): 1T8I, supported by molecular dynamics simulations illustrating strong ligand interactions. Analysis of pharmacophore kinetics highlighted the complex’s hydrophilic nature, indicating its potential therapeutic efficacy.

Cooperation between the Russian Federation and the Socialist Republic of Vietnam used to be concentrated mainly on such areas as security, defen􀉫e, culture and education. Currently, under the general influence of the global economy, especially at a time when the United States and European Union countries are imposing tough sanctions against the Russian economy, Vietnam has become an important economic partner of Russia, therefore, economic cooperation between the two countries is expanding. One of the conditions for success in the international business communication is the knowledge of the partner’s language and culture, since each language has its own ways of expressing communicative intentions, the differences of which can cause failures in cross-cultural business communication. In this regard, the study of ways of expressing communicative intentions in each partner’s language becomes urgent. Based on this, the purpose of this article is to study Russian and Vietnamese stereotypes of communicative behavior, which should help optimise the efficiency of cross-cultural business communication between native Russian and Vietnamese speakers.

The purpose of this study focuses on presenting the food and drink process in the case of making lychee juice and lychee-tea combination fruit juice in a tropical country such as Vietnam. We mainly use methods of qualitative analysis, synthesis and inductive methods, with description and explanatory methods. Authors also use a value chain approach from a material supply (lychee products) to production and market distribution. Research results show us that choosing good red lychee together with good green or black tea, esp. Lipton tea, which is produced from the region of material supplying in the Northern region of Vietnam, then mixed with sugar and ice, using little vegetables will be very good for everybody health, functioning as medical treatment to prevent heart disease, and helps men and women stronger. In the meantime, we also propose lychee and tea planting policies and capital financing policies in the country, esp. In the north of Vietnam. For instance, the nation needs to continue to negotiate with countries that have not yet allowed Vietnam’s fresh lychee to be imported into developed countries (such as Korea, ...); The state/province cooperates with donors and businesses in trade promotion activities in potential export markets for Vietnamese lychee and fruit products (Japan, Korea, US, EU, ASEAN…).

Thanh Hoa is aiming at developing tourism as a key economic industry in 2030, creating a motivation to impulse socio-economic development, making Thanh Hoa one of the top tourism development provinces of the country. With an aim to attract more domestic and international visitors, apart from improving quality and business environment, diversifying tourism products, Thanh Hoa needs to focus on training and capacity building for tourism human resources of the province. It requires a more professional tourism human resource that is equipped with essential skills to adapt and meet the demand of tourism development at the current period of time. Hence, this article analyses the real situation of tourism human resources in Thanh Hoa Province with a view to presenting relevant forecasts and recommendations on solutions in order to improve the quality of the tourism human resource of Thanh Hoa Province in the current context.

Background: Covid - 19 is a global pandemic, affecting all areas of social life in every country. In the current conditions of the Covid-19 pandemic, individual health behaviors are of primary importance. Each citizen consciously implements their health behaviors not only to prevent them from being infected but also to help the country's prevention of Covid-19 effective. The study of factors predicting people’s health behaviors in the community will help managers come up with appropriate measures to improve public health and to quickly repel the pandemic. Objectives: The research analyzes factors predicting personal health behaviors during the Covid-19 pandemic in Vietnam, including: pandemic awareness, self-assessment of the possibility of becoming infected, fear of disease, quality of life, and mental health (anxiety). Methods: This was a cross-sectional quantitative study. Data were collected from a convenient sample of 572 people in Vietnam (118 males, 451 females; M age =27.0 (sd = 10.0) ) by a means of an online questionnaire survey. The questionnaire was constructed based on the YouGov Behavior Change questionnaire; the Fear of Coronavirus-19 Scale (FCV-19), WHOQOL-BREF, the Moral Foundation Questionnaire, and Knowledge of Covid-19. This study performed multivariate regression analysis to explore effects of moral, quality of life, knowledge and fear of Coronavirus-19 on health behaviors of participants. Result: The result showed that fear and sex factors explain 4% (R2-adj = 4%) of health behavior change in the Covid-19 pandemic. In addition, there is a signìicant relationship between health behaviors and fear, age, gender, and occupation. Conclusion: People's health behaviors are particularly concerned during the Covid-19 pandemic. Community healthcare activities for the people should be tailored to suit different population groups such as gender, age or emotional experiences. More in-depth studies are needed to find out the causes of these differences, thereby proposing practical solutions to help people practice more effective health behaviors, contributing to preventing and combating the outbreak.

Sharing the sources of Southeast Asian folklore and folk literature, magical fairy tales of Vietnam and Laos have many similarities in a motif of building orphan characters. Applying structural theory in fairy tales with immutability and changes, the structure of the story is described by a series of events “signs help to make a schematic comparison of the structure of various tales,” (Propp, 1968, p.25) the article studies the magical fairy tale Tam and Cam of Vietnam and the Golden Turtle of Laos to see the similarities and differences in the motif of building orphan characters. The similarities in the motif of building orphan characters such as: story structure, character system, incarnation motif, unique object motif, magical force motif show the common cultural space of the region. However, the difference in the situation of the story and the use of magical forces and elements in the story show the customs, belief characteristics, artistic tastes and cultural identity of each nation.

In this study, we scanned multiple published databases of gene expression in vivo of M. tuberculosis at different phases of infection in animals and humans, to select 38 proteins that are highly expressed in the active, latent and reactivation phases. The selected proteins were predicted for T and B epitopes. For each proteins, the regions containing T and B epitopes were selected at the same time to look for identical epitopes on M. smegmatis based on sequence alignments. Preliminary studies of humoral immunogenicity and cross-reactivity with M. tuberculosis in mice using two M. smegmatis-derived experimental vaccines were carried out, demonstrating the immunogenicity of M. smegmatis proteoliposomes and the recognition of M. tuberculosis proteins by the sera of animals immunized with this vaccine candidate. The conjunction of in silico and in vivo studies suggested the potential for future evaluation of M. smegmatis as vaccine candidate against tuberculosis using different strategies

Abstract Some of the changes in physiological indicators during the growth and development of litchi fruit grown in Vietnam were studied. The length and diameter of litchi fruits reached their maximum value at 10 weeks after anthesis. The content of chlorophyll in litchi peel reached its highest value at 6 weeks and decreased rapidly. The content of carotenoids was low in fruit formation and then increased rapidly until fruit ripening. The vitamin C content and reducing sugar content increased continuously and reached a maximum at 10 weeks and then decreased slightly. The starch content and lipid content reached a maximum when the fruit was 8 weeks, the total organic acid content reached a maximum when the fruit was 9 weeks and then gradually decreased. The protein content decreased from fruit formation until fruit ripening. Based on these results, we found that the litchi fruit should be harvested at 10 weeks after anthesis to ensure the nutritional value of the fruit during storage.