5 results on '"Lymphoma, B-Cell blood"'
Search Results
2. [Uveal lymphoid infiltration with systemic extension].
- Author
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Barbón García JJ, Viña Escalar C, Menéndez Fernández CL, Fernández Alvarez C, Carballo Fernández C, and Villarreal Renedo PM
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bone Marrow pathology, Choroid Diseases surgery, Choroid Neoplasms drug therapy, Choroid Neoplasms surgery, Cyclophosphamide administration & dosage, Disease Progression, Doxorubicin administration & dosage, Eye Enucleation, Glaucoma, Neovascular etiology, Glaucoma, Open-Angle surgery, Humans, Immunoglobulin kappa-Chains blood, Lymphoma, B-Cell blood, Lymphoma, B-Cell drug therapy, Lymphoma, B-Cell surgery, Lymphoma, Non-Hodgkin blood, Lymphoma, Non-Hodgkin drug therapy, Lymphoma, Non-Hodgkin surgery, Male, Neoplasm Invasiveness, Orbital Neoplasms secondary, Paraproteins, Prednisone administration & dosage, Pseudolymphoma surgery, Remission Induction, Retinal Detachment surgery, Vincristine administration & dosage, Choroid Diseases pathology, Choroid Neoplasms pathology, Glaucoma, Open-Angle etiology, Lymphoma, B-Cell pathology, Lymphoma, Non-Hodgkin pathology, Pseudolymphoma pathology, Retinal Detachment etiology
- Abstract
Case Report: We report the case of a patient who was surgically treated in his right eye because of an uncontrollable glaucoma and a retinal detachment without retinal break. Ultrasound and computed tomography showed diffuse choroidal thickening. During 6 years of follow-up, he developed a major ocular and orbitary invasion and bone marrow infiltration. He was treated by enucleation and chemotherapy with apparent total remission., Discussion: Reactive lymphoid hyperplasia of the uvea consists of a lymphocytic proliferation that primarily involves the uveal tract. This process is regarded as a low malignant condition, but this case of late diagnosis showed a tendency to orbital and systemic extension.
- Published
- 2003
3. [Splenic lymphoma with circulating hairy lymphocytes lymphoma. Clinical cytological study of 4 patients].
- Author
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Jiménez S, Molero T, Santana C, Mataix R, Guerra L, Florensa L, Woessner S, and Malcorra JJ
- Subjects
- Aged, Antigens, Neoplasm analysis, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bone Marrow pathology, Combined Modality Therapy, Cyclophosphamide administration & dosage, Diagnosis, Differential, Doxorubicin administration & dosage, Female, Humans, Hydrocortisone administration & dosage, Immunophenotyping, Karyotyping, Lymphoma, B-Cell blood, Lymphoma, B-Cell drug therapy, Lymphoma, B-Cell surgery, Male, Methotrexate administration & dosage, Methylprednisolone administration & dosage, Middle Aged, Prednisone administration & dosage, Prognosis, Splenectomy, Splenic Neoplasms blood, Splenic Neoplasms drug therapy, Splenic Neoplasms surgery, Vincristine administration & dosage, beta 2-Microglobulin analysis, Lymphoma, B-Cell pathology, Neoplastic Cells, Circulating ultrastructure, Splenic Neoplasms pathology
- Abstract
Purpose: The splenic lymphoma with circulating villous lymphocytes (SLCVL) is an infrequent disease included within the low grade non Hodgkin's lymphoma, B-cell type. The results of the study of four patients are reported., Patients and Methods: Clinical, cytological, immunophenotypic, ultrastructural, evolutive and therapeutic data have been revised in all the cases., Results: Two males and 2 females of 76, 66, 68 and 62 years, respectively were diagnosed as having SLCVL. The initial symptoms were scarce, basically asthenia, and a big spleen without significant lymphadenopaty was the most relevant physical finding in each of them. In peripheral blood leukocyte count was normal with a slight lymphocytosis and a variable percentage of villous circulating lymphocytes. The immunophenotype of peripheral blood obtained by flow cytometry was according with a mature B-cell lymphocyte population, CD 5 and CD 25 negative. The cells were positive to acid phosphatase with a diffuse pattern of variable intensity; the reaction was inhibited by tartaric acid. All the patients had BM infiltration, studied with aspiration and biopsy. One case (M,66) had an IgM monoclonal gammopathy. The ultrastructural study, performed in 3 cases, showed thin and short villous prolongations. After splenectomy, a low degree lymphoma therapy has been employed in all the cases. The follow-up ranges between, 4 years and 4 months, all the patients being alive., Conclusions: The SLCVL is a definitive entity regarding the clinical, morphologic and immunophenotype features. A long clinical evolution and a good prognosis after splenectomy are common.
- Published
- 1995
4. [Monocytoid B-cell lymphoma with peripheral blood expression at the time of its diagnosis].
- Author
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Woessner S, Florensa L, Solé F, and Acín P
- Subjects
- Aged, Female, Humans, Karyotyping, Lymphoma, B-Cell diagnosis, Lymphoma, B-Cell genetics, Lymphoma, Non-Hodgkin diagnosis, Lymphoma, Non-Hodgkin genetics, Lymphoma, B-Cell blood, Lymphoma, Non-Hodgkin blood
- Published
- 1995
5. [Splenic lymphoma with circulating villous lymphocytes. Study of 6 patients].
- Author
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Batlle M, Ribera JM, Feliu E, Millá F, Sans-Sabrafén J, Villamor N, Marill N, and Woessner S
- Subjects
- Actuarial Analysis, Aged, Aged, 80 and over, Antigens, CD analysis, Antigens, Neoplasm analysis, Biomarkers, Tumor analysis, Female, Humans, Immunophenotyping, Male, Middle Aged, Neoplastic Cells, Circulating chemistry, Splenectomy, Survival Rate, B-Lymphocytes ultrastructure, Lymphoma, B-Cell blood, Lymphoma, B-Cell diagnosis, Lymphoma, B-Cell mortality, Lymphoma, B-Cell pathology, Lymphoma, B-Cell surgery, Neoplastic Cells, Circulating ultrastructure, Splenic Neoplasms blood, Splenic Neoplasms mortality, Splenic Neoplasms pathology, Splenic Neoplasms surgery
- Abstract
Purpose: Splenic lymphoma with circulating villous lymphocytes (SLCVL) is a rare chronic B-type lymphoproliferative disorder, few series having been reported thus far. The major clinical, cytological, immunophenotypic and ultrastructural features, as well as the course and treatment of six cases seen in three hospitals of the Barcelona area in six years are reported herein., Methods: The criteria of Melo et al were followed for the diagnosis of SLCVL. The clinical manifestations at onset and the morphology of lymphocytes from blood and bone-marrow (aspiration and biopsy samples) were analysed. The samples were subjected to cytochemical (acid phosphatase and L-tartaric acid inhibition), immunophenotypic (alkaline immunophosphatase and immunofluorescence) and ultrastructural studies. The histologic study of the spleen of those patients who underwent splenectomy was also performed., Results: The median age of the series was 63 years (range: 45-86). Five of the patients were women. Anaemia was the commonest clinical finding at onset, and splenomegaly was found in all cases. Villous lymphocytes were found in both peripheral blood, 3% to 85%, and bone-marrow, 31% to 70%; they showed diffuse positivity to acid phosphatase stain, this being inhibited in all cases by L-tartaric acid. None of the patients had associated monoclonal gammopathy. Bone-marrow biopsy was performed in five occasions, showing nodular infiltrative pattern in three cases, interstitial in one and diffuse pattern in another. Nodular infiltration was seen in the white pulp of spleen, with no involvement of the red pulp. The ultrastructural study of villous lymphocytes from peripheral blood or bone-marrow disclosed short, slim villi with narrow bases, no lamellar ribosomal complexes being found. Mature B-type lymphocyte proliferation was present in all instances, showing positivity for surface immunoglobulin; monoclonal antibody CD25 was negative in all cases. Three patients underwent splenectomy, and the remainders received no treatment. The expected survival at three years was 80%., Conclusions: SLCVL is a rare B-cell chronic lymphoproliferative disorder with recognised morphologic and immunophenotypic characteristics that make it distinguishable from other B-type lymphoproliferative diseases especially hairy cell leukaemia. Its clinical course is chronic and it has good prognosis. Response to splenectomy is usually favourable, although remission of the disease is not achieved.
- Published
- 1993
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