1. Coronary Artery Atherosclerosis in Hypertensive Patients: The Role of Fibrinogen Genetic Variability.
- Author
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Papageorgiou N, Briasoulis A, Hatzis G, Androulakis E, Kozanitou M, Miliou A, Charakida M, Zacharia E, Papaioannou S, Paroutoglou I, Siasos G, Pallantza Z, and Tousoulis D
- Subjects
- Alleles, Atherosclerosis blood, Atherosclerosis complications, Coronary Angiography, Coronary Artery Disease blood, Coronary Artery Disease complications, Female, Fibrinogen metabolism, Genetic Variation, Genotype, Humans, Hypertension blood, Hypertension genetics, Male, Middle Aged, Polymerase Chain Reaction, Risk Factors, Atherosclerosis genetics, Coronary Artery Disease genetics, Coronary Vessels diagnostic imaging, DNA genetics, Fibrinogen genetics, Hypertension complications, Polymorphism, Genetic
- Abstract
Introduction and Objectives: We examined whether the rs180070 and rs2070011 polymorphisms of the fibrinogen gene could affect the risk of coronary artery disease in hypertensive patients by modifying the inflammatory process and coagulation., Methods: A total of 744 participants underwent coronary angiography due to symptoms of stable angina, while hypertension was present in 332 patients., Results: The presence of the A allele (rs180070) was associated with significantly high levels of fibrinogen in hypertensive patients (P=.05). On multivariate analysis, A homozygosity (rs180070) (β = 0.257 ± 18.6; P<.001), but not hypertension status (β = 0.05 ± 11.9; P=.29) was an independent predictor of fibrinogen levels. In hypertensive patients, higher fibrinogen levels>443mg/dL (odds ratio = 3.50; 95% confidence interval, 1.14-10.90; P=.029), but not A homozygosity (odds ratio = 3.00; 95% confidence interval, 0.78-11.90; P = .110) were independent predictors of the presence of coronary artery disease. Moreover, interleukin-6 levels were higher in A homozygotes for the rs180070 polymorphism compared with all other genotypes (P=.046). Indeed, this genotype was the only adjusted independent predictor of interleukin-6 levels (β = 0.151 ± 0.642; P=.032). It was also associated with higher D-dimer levels in hypertension compared with G allele carriers (P=.048)., Conclusions: The presence of A homozygosity (rs180070) is associated with increased levels of inflammatory mediators and a higher incidence of angiographic coronary artery disease. Importantly, fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients., (Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2017
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